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The map label for this gene is pepA

Identifier: 52842837

GI number: 52842837

Start: 2972463

End: 2973947

Strand: Direct

Name: pepA

Synonym: lpg2631

Alternate gene names: 52842837

Gene position: 2972463-2973947 (Clockwise)

Preceding gene: 52842833

Following gene: 52842838

Centisome position: 87.48

GC content: 42.63

Gene sequence:

>1485_bases
TTGTCTTTCTCAAGCGGTGCAGGAAAAAATATTATGAATTATGGATTAACTCATACCCCCTCATTAACCACGAGCGAATG
TCTGGTGTTAGGCGTTTTTTCAGATTTGGCGCTACCAGATTTTGCAAATGCAATTGATAATGAACAGCAAGGCCTGATTA
AAAAACTTTGCCAGAGAGTCCCTGAACCAGGAAATACTGTATGGCAAACTGATGTTGAAGGACATAGCCTATTAATCATT
CAGTGTGGCAAAAAGGAAGAGTTTAGTGCTAATTCACTCCAAAAACGTGTAGGAGAAATTACCGAAGCATTAATTAAACA
GCGTTTCTCTTCTGCCACCGTGTGCTTGCCTCGGTTAACTCAGGAATCTGCTGAATGGCAGATAGAGCAAATGATTGTTC
AAATCGATAATTTACGATATCAACTTCTTGATTTTAAAACGAAAAATGCAAAAAGTCATAAATTGGAGTCGGTAATATTC
CATCTGCCTGGAGCTACTGAAAAAAGCCTTGAAATGGCCAAAGCCATTGTTACCGGAGTTGAATTTTGCCGTGATTTAGC
GAATATGCCGGCCAATATTTGTACTCCGACTTACCTTGGTGAGCAAGCCATTTTATTATCCAAACAATTCGACCAAATAA
GCTGTCAAGTGATGGGGCCAGAAGAAATAAAAGAAATGGGTATGGGCGCATTATTAGCCGTTGCCCAAGGAAGTGACCAA
CCCCCAAGATTGATAGATGTTCATTATCACGGTAACAAAAACTCAGCACCGGTCATTCTTGTCGGGAAAGGCATTACTTT
TGACTCAGGAGGCTTATCTATAAAGCCGGCCAACGCCATGGATGAAATGAAATACGATATGTCTGGCGCTGCCAGTGTGC
TGGGAGTTATAAAAGCCTGTGCTTTGCTGAAATTGCCAATTAATCTTATCGGCATTATAGCCAGTGCTGAAAATTTGATA
AGTGGCTCCGCTGTAAAATCAGGAGACATTGTAACCACCATGTCAGGACAAACTGTCGAAATTATCAATACCGATGCGGA
GGGTCGATTAGTACTAGCAGACGCTTTGACTTACGCGGAGCGATATAATCCTGATTTTGTAATCGATATTGCTACTTTAA
CAGGAGCGATAATCGTCGCTTTGGGCAATATAGCTACTGGCTATATGACTAGAGATGAACAGCTGGCCAAATCAATCGAA
CGTGCCGCTAATGAAAGCCAGGATAAAGTCTGGCGTATGCCACTGGATGAGGCCTATCAAGATGCTTTGGAAAGCCCATT
GGCTGATATGATCAACGCCGGCTTTGATCGCAGTGCAGGAAGTATTACTGCCGCCTGTTTCTTATCACGGTTTACTGAAA
AATATCGTTGGGCCCATTTGGACATCGCGGGAACGGCCTGGATTTCTGGAAAGAAGCGTAATGCAACAGGGCGTCCTGTT
CCTTTATTAATTCAATTATTGCGCCATGTCGCCAATTCGCGTTGA

Upstream 100 bases:

>100_bases
TGATAATTCAAGACAGCCTATTTAAAAATAGTATTGATTTAAAACAGATGATTAAAACAGAATTTTTCATTCAAATGCTT
ATCCAATTTAGGTAAACTAG

Downstream 100 bases:

>100_bases
TTTTTACTTATTAGCCAGCAGCCTTCCAGAATCTCGCTGGTTGGTTGCTTGTCGTTTAATAGAAAAAGCCTATACCAAAG
GACATACTATTTTTGTTTTT

Product: aminopeptidase A/I

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSFSSGAGKNIMNYGLTHTPSLTTSECLVLGVFSDLALPDFANAIDNEQQGLIKKLCQRVPEPGNTVWQTDVEGHSLLII
QCGKKEEFSANSLQKRVGEITEALIKQRFSSATVCLPRLTQESAEWQIEQMIVQIDNLRYQLLDFKTKNAKSHKLESVIF
HLPGATEKSLEMAKAIVTGVEFCRDLANMPANICTPTYLGEQAILLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQ
PPRLIDVHYHGNKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLI
SGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIE
RAANESQDKVWRMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPV
PLLIQLLRHVANSR

Sequences:

>Translated_494_residues
MSFSSGAGKNIMNYGLTHTPSLTTSECLVLGVFSDLALPDFANAIDNEQQGLIKKLCQRVPEPGNTVWQTDVEGHSLLII
QCGKKEEFSANSLQKRVGEITEALIKQRFSSATVCLPRLTQESAEWQIEQMIVQIDNLRYQLLDFKTKNAKSHKLESVIF
HLPGATEKSLEMAKAIVTGVEFCRDLANMPANICTPTYLGEQAILLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQ
PPRLIDVHYHGNKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLI
SGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIE
RAANESQDKVWRMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPV
PLLIQLLRHVANSR
>Mature_493_residues
SFSSGAGKNIMNYGLTHTPSLTTSECLVLGVFSDLALPDFANAIDNEQQGLIKKLCQRVPEPGNTVWQTDVEGHSLLIIQ
CGKKEEFSANSLQKRVGEITEALIKQRFSSATVCLPRLTQESAEWQIEQMIVQIDNLRYQLLDFKTKNAKSHKLESVIFH
LPGATEKSLEMAKAIVTGVEFCRDLANMPANICTPTYLGEQAILLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQP
PRLIDVHYHGNKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLIS
GSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIER
AANESQDKVWRMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVP
LLIQLLRHVANSR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=325, Percent_Identity=45.2307692307692, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI47155554, Length=361, Percent_Identity=33.7950138504155, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1790710, Length=489, Percent_Identity=43.9672801635992, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI87082123, Length=324, Percent_Identity=40.4320987654321, Blast_Score=201, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=294, Percent_Identity=36.3945578231293, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=250, Percent_Identity=30.8, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355725, Length=312, Percent_Identity=35.8974358974359, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24661038, Length=312, Percent_Identity=35.5769230769231, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20129969, Length=318, Percent_Identity=36.4779874213836, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355645, Length=318, Percent_Identity=35.2201257861635, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24662223, Length=318, Percent_Identity=35.2201257861635, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161077148, Length=320, Percent_Identity=35.3125, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI20130057, Length=320, Percent_Identity=35.3125, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24662227, Length=318, Percent_Identity=34.5911949685535, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19922386, Length=319, Percent_Identity=34.7962382445141, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20129963, Length=318, Percent_Identity=33.0188679245283, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21357381, Length=330, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221379063, Length=330, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI221379062, Length=330, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646701, Length=185, Percent_Identity=30.2702702702703, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646703, Length=185, Percent_Identity=30.2702702702703, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358201, Length=185, Percent_Identity=30.2702702702703, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53622; Mature: 53491

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSSGAGKNIMNYGLTHTPSLTTSECLVLGVFSDLALPDFANAIDNEQQGLIKKLCQRV
CCCCCCCCCHHHHCCCCCCCCCCCCHHHEEEHHHHHCCCHHHHHHCCHHHHHHHHHHHHC
PEPGNTVWQTDVEGHSLLIIQCGKKEEFSANSLQKRVGEITEALIKQRFSSATVCLPRLT
CCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHH
QESAEWQIEQMIVQIDNLRYQLLDFKTKNAKSHKLESVIFHLPGATEKSLEMAKAIVTGV
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHH
EFCRDLANMPANICTPTYLGEQAILLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQ
HHHHHHHHCCCHHCCCCCCCCCHHHHHHCCCCEEEEEECHHHHHHCCCCEEEEEECCCCC
PPRLIDVHYHGNKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKAC
CCCEEEEEEECCCCCCCEEEEECCEEECCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHH
ALLKLPINLIGIIASAENLISGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAE
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEHHHHHHHH
RYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVWRMPLDEAYQ
HCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHEECCCHHHHHH
DALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPV
HHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECEEEEECCCCCCCCCCCH
PLLIQLLRHVANSR
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SFSSGAGKNIMNYGLTHTPSLTTSECLVLGVFSDLALPDFANAIDNEQQGLIKKLCQRV
CCCCCCCCHHHHCCCCCCCCCCCCHHHEEEHHHHHCCCHHHHHHCCHHHHHHHHHHHHC
PEPGNTVWQTDVEGHSLLIIQCGKKEEFSANSLQKRVGEITEALIKQRFSSATVCLPRLT
CCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHH
QESAEWQIEQMIVQIDNLRYQLLDFKTKNAKSHKLESVIFHLPGATEKSLEMAKAIVTGV
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHH
EFCRDLANMPANICTPTYLGEQAILLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQ
HHHHHHHHCCCHHCCCCCCCCCHHHHHHCCCCEEEEEECHHHHHHCCCCEEEEEECCCCC
PPRLIDVHYHGNKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKAC
CCCEEEEEEECCCCCCCEEEEECCEEECCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHH
ALLKLPINLIGIIASAENLISGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAE
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEHHHHHHHH
RYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVWRMPLDEAYQ
HCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHEECCCHHHHHH
DALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPV
HHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECEEEEECCCCCCCCCCCH
PLLIQLLRHVANSR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA