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The map label for this gene is ahpC [C]

Identifier: 52842560

GI number: 52842560

Start: 2654814

End: 2655452

Strand: Reverse

Name: ahpC [C]

Synonym: lpg2350

Alternate gene names: 52842560

Gene position: 2655452-2654814 (Counterclockwise)

Preceding gene: 52842562

Following gene: 161723244

Centisome position: 78.15

GC content: 38.18

Gene sequence:

>639_bases
TTGTTTATCGTTTTGATAAAAACAATTGATTTTATTTATTTAGCGGTTTCACCTAAATTTAACAATGAAAATGGTGTTAA
TTTAATGAGGAGAAAACTTATGATTACGGTAGGCAACAAATTTCCAGAGTTTCAACTTAAAGCAACGGTGGCCAATGATG
TAAGTAATGCATTTCAAATGATCTCTAATGAAACGTATCGGGGTAAATGGTTAGTCGTATTTTTTTGGCCTAAAGATTTT
ACCTTTGTCTGCCCTACTGAAATTGCGGAGTTTGGAAGGCTAAATTCCGAGTTTGCCGATCGAGATGCTCAAATTCTGGG
TGGAAGCACAGACAGTGAATTTGTACACTTGGCCTGGAGAAATCAGCATCCGGACTTAAACAATTTGCCATTTCCCATGC
TGGCTGATGTTAAACGAGAATTGACAGCAAATTTGGGCATATTGGATGACGAGGAGGGAGTTGCCCAACGTGCGACATTT
ATTGTAGACCCTCAGGGAATTACTCGTTTTGTGATGGTTACGGATTTAAATGTAGGGCGCAATCCAGCTGAAGTATTACG
TGTTCTGGATGCTTTACAGACCGATGAACTTTGTCCATGTAATTGGAAAAAAGGTGAAGAAACAATTCATATCAAATAA

Upstream 100 bases:

>100_bases
ACCAATATTCCTCCACAGGCCCTTCTTTAAAAGTAGTTTATAAAAACATAAAAGCCAAATATTTTGCAAAATGGATTAAT
AATTTTTATTATGATTAATT

Downstream 100 bases:

>100_bases
ATTGAAAAAAGAGGCATCAATCATGTTAGAGAATGTTAAAGAAAGTATACCGGAAGTGGCTAAAGACATACGCTTGAATT
TGACTAAGGTACTTGATCTG

Product: alkylhydroperoxide reductase

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MFIVLIKTIDFIYLAVSPKFNNENGVNLMRRKLMITVGNKFPEFQLKATVANDVSNAFQMISNETYRGKWLVVFFWPKDF
TFVCPTEIAEFGRLNSEFADRDAQILGGSTDSEFVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATF
IVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQTDELCPCNWKKGEETIHIK

Sequences:

>Translated_212_residues
MFIVLIKTIDFIYLAVSPKFNNENGVNLMRRKLMITVGNKFPEFQLKATVANDVSNAFQMISNETYRGKWLVVFFWPKDF
TFVCPTEIAEFGRLNSEFADRDAQILGGSTDSEFVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATF
IVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQTDELCPCNWKKGEETIHIK
>Mature_212_residues
MFIVLIKTIDFIYLAVSPKFNNENGVNLMRRKLMITVGNKFPEFQLKATVANDVSNAFQMISNETYRGKWLVVFFWPKDF
TFVCPTEIAEFGRLNSEFADRDAQILGGSTDSEFVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATF
IVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQTDELCPCNWKKGEETIHIK

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=180, Percent_Identity=43.3333333333333, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI4505591, Length=180, Percent_Identity=41.6666666666667, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI32455266, Length=180, Percent_Identity=41.6666666666667, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI32455264, Length=180, Percent_Identity=41.6666666666667, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI32483377, Length=184, Percent_Identity=36.9565217391304, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI5802974, Length=163, Percent_Identity=39.2638036809816, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI5453549, Length=163, Percent_Identity=41.1042944785276, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4758638, Length=191, Percent_Identity=33.5078534031414, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI33188454, Length=109, Percent_Identity=39.4495412844037, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1786822, Length=157, Percent_Identity=37.5796178343949, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17554494, Length=178, Percent_Identity=42.1348314606742, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193204376, Length=189, Percent_Identity=39.1534391534392, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32565831, Length=180, Percent_Identity=40.5555555555556, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25153706, Length=193, Percent_Identity=31.6062176165803, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323613, Length=184, Percent_Identity=41.304347826087, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320661, Length=184, Percent_Identity=41.304347826087, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319407, Length=186, Percent_Identity=32.258064516129, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17738015, Length=185, Percent_Identity=42.1621621621622, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI17157991, Length=163, Percent_Identity=43.558282208589, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24641739, Length=163, Percent_Identity=43.558282208589, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21357347, Length=183, Percent_Identity=36.0655737704918, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24656348, Length=175, Percent_Identity=37.1428571428571, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17864676, Length=175, Percent_Identity=37.1428571428571, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17975518, Length=156, Percent_Identity=35.8974358974359, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24652434, Length=156, Percent_Identity=35.8974358974359, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652436, Length=156, Percent_Identity=35.8974358974359, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581278, Length=185, Percent_Identity=30.2702702702703, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 24171; Mature: 24171

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIVLIKTIDFIYLAVSPKFNNENGVNLMRRKLMITVGNKFPEFQLKATVANDVSNAFQM
CEEEEEEEEEEEEEEECCCCCCCCCHHHHHHEEEEEECCCCCCEEEEEEHHHHHHHHHHH
ISNETYRGKWLVVFFWPKDFTFVCPTEIAEFGRLNSEFADRDAQILGGSTDSEFVHLAWR
HCCCCCCCEEEEEEECCCCCEEECCHHHHHHCCCCCHHHCCCCEEECCCCCCCEEEEEEC
NQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATFIVDPQGITRFVMVTDLNVGR
CCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCHHHHEEEEECCCCCEEEEEEEECCCCC
NPAEVLRVLDALQTDELCPCNWKKGEETIHIK
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MFIVLIKTIDFIYLAVSPKFNNENGVNLMRRKLMITVGNKFPEFQLKATVANDVSNAFQM
CEEEEEEEEEEEEEEECCCCCCCCCHHHHHHEEEEEECCCCCCEEEEEEHHHHHHHHHHH
ISNETYRGKWLVVFFWPKDFTFVCPTEIAEFGRLNSEFADRDAQILGGSTDSEFVHLAWR
HCCCCCCCEEEEEEECCCCCEEECCHHHHHHCCCCCHHHCCCCEEECCCCCCCEEEEEEC
NQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATFIVDPQGITRFVMVTDLNVGR
CCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCHHHHEEEEECCCCCEEEEEEEECCCCC
NPAEVLRVLDALQTDELCPCNWKKGEETIHIK
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA