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The map label for this gene is sdaC

Identifier: 52842531

GI number: 52842531

Start: 2622446

End: 2623807

Strand: Direct

Name: sdaC

Synonym: lpg2321

Alternate gene names: 52842531

Gene position: 2622446-2623807 (Clockwise)

Preceding gene: 52842529

Following gene: 52842537

Centisome position: 77.18

GC content: 35.9

Gene sequence:

>1362_bases
GTGTTAATATTGATCAACCTGCGAGGCGCTATTTTATTAGTTAGTATTAAAACGAGGATGTTTTTCATGTCATCAAATGA
ATCTGCAGCTATAGTATCTCCGATAGTCAACCAAAAACTATCACAATGGAAAAAACAAGATACGATTTGGATGTTAAGCC
TCTATGGCACAGCAATTGGTGCCGGAACTCTTTTCCTTCCTATAGATGCTGGTCTTAATGGCATTTTGCCTTTAATCATT
ATGACAATTCTGGCCTTCCCCATGACTTATTATTCTCATAGGGCTTTATGTCGTTTTGTCCTTTCAGGCTCGTCCTCACA
CAATGACATCACCGATGTTGTAGAAGAACACTTTGGCTCATTTGCGGGTAAGATGCTAACTATCCTGTACTTTTTTGCGA
TTTATCCAATTTTGCTTATGTACAGTGTCGCAATAACTAATACCACGGAAAGTTTCCTGATTAATCAAATGGGAATTACC
CCTCCGCCACGGGCTCTTTTAGCAATCATATTAATTCTTGGGTTAATGGGTATCGTGCGTTTAGGACAAGAAATTATTGT
CAAATCGATGTCGGTATTGGTATATCCTTTTGCCACTATTCTATTTCTGCTTTCGCTTTATTTAATTCCAAATTGGAATA
ACGCTATTTTTATCCAAAGCAATTCCTTACATGCCAATGGAGGGCATGGACTATTAATGACTTTATGGTTAATTATTCCA
GTGATGGTGTTCTCCTTTAACCATTCTCCTATCATTTCATCTTTTGCTGTGAATCAAAAGCAGCAATATGGTAGCCAAGC
TGACGAGAAAAGCTCATTAATTATGAAATACAGTCACTTGATGATGGTTTTCTCTGTGATGTTTTTTGTATTTAGCTGTG
TGTTGAGCCTGTCACCTCAAGATCTTTTGCAAGCAAAGCAACAAAATATTTCCATTTTGTCTTATCTGGCGAATCATTTT
AATACCCCTATTATGGCCTATATTGCACCGGTTATTGCATTCATAGCCATTTCAAAATCTTTTCTGGGACATTATTTAGG
TGCCAAGGAAGGTTTAAGTGGAATTATTGTTAAATCATTAAAATCAACAACAGGCAAAACAATTAATAAGAATTCCCTGC
ACAGAATCATTGAAATCTTTATGATTCTGACTTGTTGGGTTGTTGCTACAATTAATCCTAATATTTTAAAAATGATTGAA
ACATTAGGAGGTCCCATCATAGCTGTCTTATTATTTATCATGCCAATGTATGCCATTGCTAAAGTGCCAGCCATGAAAAA
ATACAACAATCAAATCAGTAACGTATTTGTTACCGTCATGGGCATTATTTCTATCTCAGCCATCATTTATGGCTTAATTT
AA

Upstream 100 bases:

>100_bases
AAGGCCATTTTCCTCGCTCCTTACCTTAAATTAATCTCTTGCTTTGTTCATTTCAGTTGGATATGATTTAGTTCGCAATT
GTTGAAATATTGTCTTTGTA

Downstream 100 bases:

>100_bases
CAATTAATCTGCTAATTGCATATATTTATTAAGGCGTATATTACGCCTTAATAATATTGCTAAACATTGGTATTTTTCTC
AATAGAATGAACTTAGATTT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLILINLRGAILLVSIKTRMFFMSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLII
MTILAFPMTYYSHRALCRFVLSGSSSHNDITDVVEEHFGSFAGKMLTILYFFAIYPILLMYSVAITNTTESFLINQMGIT
PPPRALLAIILILGLMGIVRLGQEIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIP
VMVFSFNHSPIISSFAVNQKQQYGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQAKQQNISILSYLANHF
NTPIMAYIAPVIAFIAISKSFLGHYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIE
TLGGPIIAVLLFIMPMYAIAKVPAMKKYNNQISNVFVTVMGIISISAIIYGLI

Sequences:

>Translated_453_residues
MLILINLRGAILLVSIKTRMFFMSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLII
MTILAFPMTYYSHRALCRFVLSGSSSHNDITDVVEEHFGSFAGKMLTILYFFAIYPILLMYSVAITNTTESFLINQMGIT
PPPRALLAIILILGLMGIVRLGQEIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIP
VMVFSFNHSPIISSFAVNQKQQYGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQAKQQNISILSYLANHF
NTPIMAYIAPVIAFIAISKSFLGHYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIE
TLGGPIIAVLLFIMPMYAIAKVPAMKKYNNQISNVFVTVMGIISISAIIYGLI
>Mature_453_residues
MLILINLRGAILLVSIKTRMFFMSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLII
MTILAFPMTYYSHRALCRFVLSGSSSHNDITDVVEEHFGSFAGKMLTILYFFAIYPILLMYSVAITNTTESFLINQMGIT
PPPRALLAIILILGLMGIVRLGQEIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIP
VMVFSFNHSPIISSFAVNQKQQYGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQAKQQNISILSYLANHF
NTPIMAYIAPVIAFIAISKSFLGHYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIE
TLGGPIIAVLLFIMPMYAIAKVPAMKKYNNQISNVFVTVMGIISISAIIYGLI

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=432, Percent_Identity=64.3518518518518, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1789504, Length=446, Percent_Identity=46.8609865470852, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=37.956204379562, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI145693183, Length=405, Percent_Identity=26.1728395061728, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789961, Length=400, Percent_Identity=27.5, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 50143; Mature: 50143

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILINLRGAILLVSIKTRMFFMSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIG
CEEEEEECCEEEEEEEHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHC
AGTLFLPIDAGLNGILPLIIMTILAFPMTYYSHRALCRFVLSGSSSHNDITDVVEEHFGS
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FAGKMLTILYFFAIYPILLMYSVAITNTTESFLINQMGITPPPRALLAIILILGLMGIVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGQEIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCCCHHHHHHHHHHH
VMVFSFNHSPIISSFAVNQKQQYGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQ
HHHHHCCCCCHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DLLQAKQQNISILSYLANHFNTPIMAYIAPVIAFIAISKSFLGHYLGAKEGLSGIIVKSL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHH
KSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIETLGGPIIAVLLFIMPMYAIA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KVPAMKKYNNQISNVFVTVMGIISISAIIYGLI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLILINLRGAILLVSIKTRMFFMSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIG
CEEEEEECCEEEEEEEHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHC
AGTLFLPIDAGLNGILPLIIMTILAFPMTYYSHRALCRFVLSGSSSHNDITDVVEEHFGS
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FAGKMLTILYFFAIYPILLMYSVAITNTTESFLINQMGITPPPRALLAIILILGLMGIVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGQEIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCCCHHHHHHHHHHH
VMVFSFNHSPIISSFAVNQKQQYGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQ
HHHHHCCCCCHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DLLQAKQQNISILSYLANHFNTPIMAYIAPVIAFIAISKSFLGHYLGAKEGLSGIIVKSL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHH
KSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIETLGGPIIAVLLFIMPMYAIA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KVPAMKKYNNQISNVFVTVMGIISISAIIYGLI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]