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The map label for this gene is 52842469

Identifier: 52842469

GI number: 52842469

Start: 2558698

End: 2560116

Strand: Reverse

Name: 52842469

Synonym: lpg2256

Alternate gene names: NA

Gene position: 2560116-2558698 (Counterclockwise)

Preceding gene: 52842470

Following gene: 52842468

Centisome position: 75.35

GC content: 40.45

Gene sequence:

>1419_bases
TTGGCAATAGGTCGTATTATTCATTACAGTACTGCGAATGACATACAACAAGGTATTATTATGAAATTGTCTTTTTTAGG
TGCGACTGGTACGGTTACCGGCTCTAAGTACCTGGTAGAATCAAATAATAAAAAGATTTTGGTAGATTGCGGACTTTTCC
AGGGTTTAAAAGAATTGAGACTAAGAAACTGGTCACCCCTTCCTGTGTCTCCCAAATCAATAGATGCTGTTGTTTTGACC
CACGCACATATTGATCATAGCGGTTATTTGCCATTATTGGTGAAACAAGGATTTAAGGGGCGCATCTATGCAACTGCTGC
GACAACCGATTTATGTTCTATCTTACTGCCCGATAGCGGTTTTTTGCACGAGGAAGATGCCAGAAGGGCAAATAAATATG
GGTATAGCAAGCACCATCCGGCTTTACCTTTGTATACTCAGGAAGATGCAAATAATACCTTAAAGTATTTTGAATCAGTA
GAATATGACACCCCTTATCCTTTAATGGATGATTGCGAAATCAGTTGGCATAGGGCTGGGCATATATTAGGGTCTGCATT
TATTCAATTTCAAACAAAGCAAATCAAGTTATTATTTAGTGGTGATATTGGAAGACTCAATGATCCTGTTATGAAGCCTT
CCGAGTTAATGAAATCTACCGATTATTTGGTGATTGAATCAACTTATGGGAATCGCTTGCATGATAAAACCGATCCTTTA
GCGTTTATAGCCAACATAGTCAATACGACTTGTAAAAGAGGCGGTACAGTGCTAATTCCTGCTTTTGCAGTCGGTAGAGC
ACAAACTATGTTGTATTATTTGTATATTTTAAAACAAAAAAAATTAATTCCTGATGTCCCTGTCTATCTGGATAGCCCTA
TGGCTATTGATGCCACTGAATTATTATTAAAACATCATAACGAACACCGCTTAAGTGCAGAGGAGTGCCGAGCCGTCTGC
CAAATAGCGACTTATGTCCATGCCCCAAATGAATCCATGGCAGTGGATTGGGAGCGCGAATCTAAAATTATTATTTCTGC
AAGTGGCATGATGACAGGGGGCCGGGTTTTGCATCATTTGAAGGTATATGCTCCTGATCCTGCAAGTACTATCCTTTTGA
CTGGATTCCAGGCTGCTGGAACGAGAGGTGAAAAAATGTTAAATCATGAGCCGTCCGTTAAAATCCATGGTGATGATTAC
CCCGTCAGGGCTCAGGTAGCTACGTTAACCAATGCCTCTGCTCATGCAGATTATGAGGAAATACTAATTTGGCTAAAGCA
TTTTGAGAAGGCCCCAAAGGAAGTCTTTATTACCCATGGCGAGCCTCAAGCGGCATTGGGATTAAAGGGGCATATTGAAA
CGGAACTGGGGTGGAATTGTAAGATACCTGACTATCTTCAAAAGGTAAACTTGGATTGA

Upstream 100 bases:

>100_bases
ACTTAAAAAACAGTTTTATAAAAATATCCACACCGTAAGTGCAAAAGAATGGGCGGGATAAAAAGTTAGCATTTGAAGCT
TCAAATGACTTTAAAATAAA

Downstream 100 bases:

>100_bases
TAAATCCCAAGAATAGTACTTAATTTAATATTCTGAGCAAAAGTGGTTAGTCCCCTAAAAATCAGCTTTAGTTGAAACAG
TTGGGCATGAATTGAATCTG

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAIGRIIHYSTANDIQQGIIMKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPKSIDAVVLT
HAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESV
EYDTPYPLMDDCEISWHRAGHILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPL
AFIANIVNTTCKRGGTVLIPAFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVC
QIATYVHAPNESMAVDWERESKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDY
PVRAQVATLTNASAHADYEEILIWLKHFEKAPKEVFITHGEPQAALGLKGHIETELGWNCKIPDYLQKVNLD

Sequences:

>Translated_472_residues
MAIGRIIHYSTANDIQQGIIMKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPKSIDAVVLT
HAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESV
EYDTPYPLMDDCEISWHRAGHILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPL
AFIANIVNTTCKRGGTVLIPAFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVC
QIATYVHAPNESMAVDWERESKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDY
PVRAQVATLTNASAHADYEEILIWLKHFEKAPKEVFITHGEPQAALGLKGHIETELGWNCKIPDYLQKVNLD
>Mature_471_residues
AIGRIIHYSTANDIQQGIIMKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPKSIDAVVLTH
AHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVE
YDTPYPLMDDCEISWHRAGHILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPLA
FIANIVNTTCKRGGTVLIPAFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVCQ
IATYVHAPNESMAVDWERESKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDYP
VRAQVATLTNASAHADYEEILIWLKHFEKAPKEVFITHGEPQAALGLKGHIETELGWNCKIPDYLQKVNLD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=432, Percent_Identity=27.7777777777778, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI33300633, Length=463, Percent_Identity=26.5658747300216, Blast_Score=146, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI32566029, Length=438, Percent_Identity=27.6255707762557, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32564696, Length=447, Percent_Identity=26.3982102908277, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323307, Length=469, Percent_Identity=24.5202558635394, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24648013, Length=453, Percent_Identity=27.3730684326711, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21358523, Length=464, Percent_Identity=26.0775862068966, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52676; Mature: 52545

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIGRIIHYSTANDIQQGIIMKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELR
CCCCEEEEECCHHHHHHHHEEEEEEECCCCEECCCEEEEECCCCEEEEECHHHHHHHHHH
LRNWSPLPVSPKSIDAVVLTHAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSG
HCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHCCCCCCCEEEEEECHHHHHHEECCCCC
FLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMDDCEISWHRAG
CCCCHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPL
HHHHHHHEEEEEEEEEEEEECCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCHH
AFIANIVNTTCKRGGTVLIPAFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATE
HHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHH
LLLKHHNEHRLSAEECRAVCQIATYVHAPNESMAVDWERESKIIISASGMMTGGRVLHHL
HHHHCCCCCCCCHHHHHHHHHHHHHEECCCCCEEEEECCCCEEEEEECCCCCCCCEEEEE
KVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDYPVRAQVATLTNASAHADYEE
EEECCCCCCEEEEECCHHCCCCCHHHHCCCCCEEECCCCCCEEEEEEEECCCCCCCCHHH
ILIWLKHFEKAPKEVFITHGEPQAALGLKGHIETELGWNCKIPDYLQKVNLD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCEEECCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
AIGRIIHYSTANDIQQGIIMKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELR
CCCEEEEECCHHHHHHHHEEEEEEECCCCEECCCEEEEECCCCEEEEECHHHHHHHHHH
LRNWSPLPVSPKSIDAVVLTHAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSG
HCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHCCCCCCCEEEEEECHHHHHHEECCCCC
FLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMDDCEISWHRAG
CCCCHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPL
HHHHHHHEEEEEEEEEEEEECCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCHH
AFIANIVNTTCKRGGTVLIPAFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATE
HHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHH
LLLKHHNEHRLSAEECRAVCQIATYVHAPNESMAVDWERESKIIISASGMMTGGRVLHHL
HHHHCCCCCCCCHHHHHHHHHHHHHEECCCCCEEEEECCCCEEEEEECCCCCCCCEEEEE
KVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDYPVRAQVATLTNASAHADYEE
EEECCCCCCEEEEECCHHCCCCCHHHHCCCCCEEECCCCCCEEEEEEEECCCCCCCCHHH
ILIWLKHFEKAPKEVFITHGEPQAALGLKGHIETELGWNCKIPDYLQKVNLD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCEEECCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA