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The map label for this gene is yqjD [H]

Identifier: 52842440

GI number: 52842440

Start: 2517274

End: 2518713

Strand: Reverse

Name: yqjD [H]

Synonym: lpg2227

Alternate gene names: 52842440

Gene position: 2518713-2517274 (Counterclockwise)

Preceding gene: 52842446

Following gene: 52842439

Centisome position: 74.13

GC content: 42.01

Gene sequence:

>1440_bases
TTGCAAGAGGAAAGAGGTATGTCTTCCCAACATACAGATAAGACGTTAATTAAATGGATAGATAATTTAATTGATGAACA
AAGCTTTTTACCAATAGGTTCTGAATATATTCCAGATAATAATCTTCATTCCCTTCCTGGCGCTGAGGTGATTACCGGAT
TAGCCAAAGTGAATCAAAGGCCAGTAGCGATTTATGCTCATGATTCTTCAGTCAACAGGGGGTATGTTACCCGACAAGGC
GCTAGAAAGATTATTCATTTAATGGATAAGGCGGAAAAATTACGCATTCCTATTGTTGCCTTTTTAGCATCTCCCGGGGT
TTCTCTCGAAGAAAATTTGCTGAGTGGCGACGAATACACTCAAATTATTGCTCGAAATATTAGACTGTCAGGAATTATCC
CACAATTTGCAGTGATACTGGCACCCACTCTTGGAGCTCCGGCCTATTCTGCTGTGTTAATGGACTTATTATTTTTTAAC
AAGCATAGAAGCTATCTTATGGTGACTAGCCCTACGGTAGTACAACAAGCCATTAGTGAAAAAGTGACTATGGGCGAGCT
GGGGAGCGCAACACTGCATGCAACGACAACGGGTATTGCTGATTTCGTGGACGATAGTGTTACCGCACAAATAAACCATG
TGAAAGCAATGCTTGGCTTTTTTCCTCTACATACCAATGAACGTCCGCCAGTTCATCCTATCATGGAGCCTAATCACCCC
ATTCCTGATATTCCTGCAAATCCGAGAATGCCATTTAATATGCTCAATTTAATTCAGGCTGTCGTGGATAATTCAAACGT
TATCCAGTACAAAAGGACTTATGGACAGGCGATGATTTGTGCTTTTGTGCATATACATGGCTTTGCTGTTGGGGTCGTCG
CTAATCAAAGCATTCGTTACAGCGGAGCCATCGATTCCGATGCAGCTCAAAAAGCAGCCAAATTTATAAGAATATGTGAT
GCTTATTCTATTCCAATTTTGACTTTTATCGATGTTCCCGGTTTTATGCCCGGTAAAAGAGAGGAGCAAAAGGGATTATT
GCAGCATGGTGCAAGGTTTTGCGTAGCTATGCAAACCAGAGTGCCAAGGCTAAGTGTCATCGTGCGTAAATGTTATGGAG
CGGCAGCCTTTCTCATGATGCAAACCAAATCACAGAATGGCGATTTGGTTTTGGCTCTGGAAACAGCAAATCTTGGTGTC
ATGGGGAAGGAAACAACTAATAAGGTGCAAGCCATGGATGGTCAACCAGTACAGGAATCATCACAATCCCAATTGACAGA
AAAGTCTCAAATTGATGATTCCCTCATGGAGGCTTATTCATTGGGCTTGATTGATGAAATTATCCAGGCAGCGCAAATTC
GCAGTCGTCTTGCCTCCCATTTGGAGTTTTTATATAGAAGCATGGAAACCATGCCCCCGGCAAAACACTCTATTGTATAA

Upstream 100 bases:

>100_bases
AAACTTATACAATTAAGAGTAGCCTATTTTGGGAATTAAGTTATTATGGATATTGATCAAATTTCCAAGTTACAAAGTCT
CAGATTCCAAGATTTAAATA

Downstream 100 bases:

>100_bases
GGAAAATAATGACCTCTTATGAAAATTTGATACAACTGTCTGAATTTTTTGAGTCATGCCTGGGTAATCCTCTGGAAAAC
AATTCCCCTGTTAATTTTCA

Product: acetyl CoA carboxylase alpha subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MQEERGMSSQHTDKTLIKWIDNLIDEQSFLPIGSEYIPDNNLHSLPGAEVITGLAKVNQRPVAIYAHDSSVNRGYVTRQG
ARKIIHLMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFN
KHRSYLMVTSPTVVQQAISEKVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTNERPPVHPIMEPNHP
IPDIPANPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDSDAAQKAAKFIRICD
AYSIPILTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGV
MGKETTNKVQAMDGQPVQESSQSQLTEKSQIDDSLMEAYSLGLIDEIIQAAQIRSRLASHLEFLYRSMETMPPAKHSIV

Sequences:

>Translated_479_residues
MQEERGMSSQHTDKTLIKWIDNLIDEQSFLPIGSEYIPDNNLHSLPGAEVITGLAKVNQRPVAIYAHDSSVNRGYVTRQG
ARKIIHLMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFN
KHRSYLMVTSPTVVQQAISEKVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTNERPPVHPIMEPNHP
IPDIPANPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDSDAAQKAAKFIRICD
AYSIPILTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGV
MGKETTNKVQAMDGQPVQESSQSQLTEKSQIDDSLMEAYSLGLIDEIIQAAQIRSRLASHLEFLYRSMETMPPAKHSIV
>Mature_479_residues
MQEERGMSSQHTDKTLIKWIDNLIDEQSFLPIGSEYIPDNNLHSLPGAEVITGLAKVNQRPVAIYAHDSSVNRGYVTRQG
ARKIIHLMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFN
KHRSYLMVTSPTVVQQAISEKVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTNERPPVHPIMEPNHP
IPDIPANPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDSDAAQKAAKFIRICD
AYSIPILTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGV
MGKETTNKVQAMDGQPVQESSQSQLTEKSQIDDSLMEAYSLGLIDEIIQAAQIRSRLASHLEFLYRSMETMPPAKHSIV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=441, Percent_Identity=32.6530612244898, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI295821216, Length=461, Percent_Identity=31.4533622559653, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI11545863, Length=446, Percent_Identity=25.3363228699552, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25147359, Length=487, Percent_Identity=28.3367556468172, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI25147362, Length=487, Percent_Identity=28.3367556468172, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17552936, Length=437, Percent_Identity=24.0274599542334, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24586065, Length=417, Percent_Identity=23.5011990407674, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 52748; Mature: 52748

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEERGMSSQHTDKTLIKWIDNLIDEQSFLPIGSEYIPDNNLHSLPGAEVITGLAKVNQR
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
PVAIYAHDSSVNRGYVTRQGARKIIHLMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYT
CEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCHHHH
QIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFNKHRSYLMVTSPTVVQQAISE
HHHHHHCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHH
KVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTNERPPVHPIMEPNHP
CCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
IPDIPANPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRY
CCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEEECCCEEE
SGAIDSDAAQKAAKFIRICDAYSIPILTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTR
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEHHHHC
VPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGVMGKETTNKVQAMDGQPVQES
CCHHHHHHHHHHHHHEEEHEEECCCCCCEEEEEEECCCCEECCCCCCHHEECCCCCCHHH
SQSQLTEKSQIDDSLMEAYSLGLIDEIIQAAQIRSRLASHLEFLYRSMETMPPAKHSIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQEERGMSSQHTDKTLIKWIDNLIDEQSFLPIGSEYIPDNNLHSLPGAEVITGLAKVNQR
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
PVAIYAHDSSVNRGYVTRQGARKIIHLMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYT
CEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCHHHH
QIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFNKHRSYLMVTSPTVVQQAISE
HHHHHHCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHH
KVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTNERPPVHPIMEPNHP
CCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
IPDIPANPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRY
CCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEEECCCEEE
SGAIDSDAAQKAAKFIRICDAYSIPILTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTR
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEHHHHC
VPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGVMGKETTNKVQAMDGQPVQES
CCHHHHHHHHHHHHHEEEHEEECCCCCCEEEEEEECCCCEECCCCCCHHEECCCCCCHHH
SQSQLTEKSQIDDSLMEAYSLGLIDEIIQAAQIRSRLASHLEFLYRSMETMPPAKHSIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]