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The map label for this gene is pcpR [H]

Identifier: 52842352

GI number: 52842352

Start: 2386207

End: 2387121

Strand: Direct

Name: pcpR [H]

Synonym: lpg2138

Alternate gene names: 52842352

Gene position: 2386207-2387121 (Clockwise)

Preceding gene: 52842347

Following gene: 52842355

Centisome position: 70.23

GC content: 33.99

Gene sequence:

>915_bases
ATGGATCTCAGAAAAATTAATCTCAACTTGTTATTGCATCTTGATACATTGTTAAATGAGCTCTCAGTATCCAAAGCGGC
TGAAAAATCTTTCATGAGCCAGACTGCAATGAGCCATATATTAAAACAATTACGTGATATATTCGATGACCCTTTGTTTA
TTAGGAAACCGCACGGGCTTCAACCAACACAAAAGGTACTTGATCTGGCCCCCAAGATTAAAAAATTTTTAAATTACTCC
AATGATATTTTTGAAGAAGATACTTTCAATCCAGGAAATGACAATTTATTTTTAAAGACTGCATCAGTAGGTACAGGGGA
ATATTTTATTTTACCCAGGTTATGTGCTCATTTGGCTAAAAATGCTCCGAAATTTGTATTAAAGATTTCTTCACTGTCAG
AGTACTTGAGTCTCGAGTATTTATTAATGTCCGAATTAGACTTTGCAATAGGACCAGGCTTTGTTGAAACGGGGAATAAC
ATCATCAGAGAATTATTGTTTGAAGAGGAGGCTGTGTGCATCATGCATAAATCTCATCCTCTCGCAAATCAGGAATTAAC
TCAAGATATGTACTTGCAAGCTGAACATGTTGACATACAATTTAGTTACATGGGAAATGAAAATATACTGTATAAAGCAT
TACAAGGATATCATCAAAGAAATATCAAAGTGATAGTGCCCAATATCATTAGCGCATTGGAAGTGGTTTACCATACGAAT
TTCATTACAACTGTACCGAGAACTCTAGCTGTTACTTTCAAAGACAGATATCAAATTGAACTACACCCTTTTCCTTTCCC
TAAAAAGACATTTTTAGTTAATTTTTACTATCATAAACGATTATCAAATCATAAACCGCTGCAATGGGTATTGGATGTAA
TAAAAAAATATTGTTGCGTCAATCATGAGGCTTAA

Upstream 100 bases:

>100_bases
AAGAAAAAGATATGGTCGGTAAATTCCAAATTGTAGTTTTTGGGCTTATTCAGTCACCCTGGATAGGAATATAAAAAAGT
TAATTTGGATTTAATGAAAA

Downstream 100 bases:

>100_bases
ACAAATTGATATTAAGGAGAAAGCAGATTCTTCTCCCAATTGTTTTTTATAAAACAATATTCTACGACATCAGACAATTC
ATCCGTTCTATAAGTATAAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDLRKINLNLLLHLDTLLNELSVSKAAEKSFMSQTAMSHILKQLRDIFDDPLFIRKPHGLQPTQKVLDLAPKIKKFLNYS
NDIFEEDTFNPGNDNLFLKTASVGTGEYFILPRLCAHLAKNAPKFVLKISSLSEYLSLEYLLMSELDFAIGPGFVETGNN
IIRELLFEEEAVCIMHKSHPLANQELTQDMYLQAEHVDIQFSYMGNENILYKALQGYHQRNIKVIVPNIISALEVVYHTN
FITTVPRTLAVTFKDRYQIELHPFPFPKKTFLVNFYYHKRLSNHKPLQWVLDVIKKYCCVNHEA

Sequences:

>Translated_304_residues
MDLRKINLNLLLHLDTLLNELSVSKAAEKSFMSQTAMSHILKQLRDIFDDPLFIRKPHGLQPTQKVLDLAPKIKKFLNYS
NDIFEEDTFNPGNDNLFLKTASVGTGEYFILPRLCAHLAKNAPKFVLKISSLSEYLSLEYLLMSELDFAIGPGFVETGNN
IIRELLFEEEAVCIMHKSHPLANQELTQDMYLQAEHVDIQFSYMGNENILYKALQGYHQRNIKVIVPNIISALEVVYHTN
FITTVPRTLAVTFKDRYQIELHPFPFPKKTFLVNFYYHKRLSNHKPLQWVLDVIKKYCCVNHEA
>Mature_304_residues
MDLRKINLNLLLHLDTLLNELSVSKAAEKSFMSQTAMSHILKQLRDIFDDPLFIRKPHGLQPTQKVLDLAPKIKKFLNYS
NDIFEEDTFNPGNDNLFLKTASVGTGEYFILPRLCAHLAKNAPKFVLKISSLSEYLSLEYLLMSELDFAIGPGFVETGNN
IIRELLFEEEAVCIMHKSHPLANQELTQDMYLQAEHVDIQFSYMGNENILYKALQGYHQRNIKVIVPNIISALEVVYHTN
FITTVPRTLAVTFKDRYQIELHPFPFPKKTFLVNFYYHKRLSNHKPLQWVLDVIKKYCCVNHEA

Specific function: Transcriptional activator for the pcpA, pcpB and pcpE genes for pentachlorophenol (PCP) degradation. Essential for PCP degradation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081684, Length=304, Percent_Identity=23.3552631578947, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790147, Length=299, Percent_Identity=24.4147157190635, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081766, Length=295, Percent_Identity=24.0677966101695, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786820, Length=76, Percent_Identity=43.421052631579, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 825 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35204; Mature: 35204

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRKINLNLLLHLDTLLNELSVSKAAEKSFMSQTAMSHILKQLRDIFDDPLFIRKPHGL
CCCEEEEHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
QPTQKVLDLAPKIKKFLNYSNDIFEEDTFNPGNDNLFLKTASVGTGEYFILPRLCAHLAK
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHC
NAPKFVLKISSLSEYLSLEYLLMSELDFAIGPGFVETGNNIIRELLFEEEAVCIMHKSHP
CCCEEEEEHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCHHHHHHHHHCCCCEEEEECCCC
LANQELTQDMYLQAEHVDIQFSYMGNENILYKALQGYHQRNIKVIVPNIISALEVVYHTN
CCHHHHHHHHHEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
FITTVPRTLAVTFKDRYQIELHPFPFPKKTFLVNFYYHKRLSNHKPLQWVLDVIKKYCCV
HHHHCCCEEEEEECCCEEEEECCCCCCCHHEEEEHHHHHHCCCCCCHHHHHHHHHHHHHC
NHEA
CCCC
>Mature Secondary Structure
MDLRKINLNLLLHLDTLLNELSVSKAAEKSFMSQTAMSHILKQLRDIFDDPLFIRKPHGL
CCCEEEEHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
QPTQKVLDLAPKIKKFLNYSNDIFEEDTFNPGNDNLFLKTASVGTGEYFILPRLCAHLAK
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHC
NAPKFVLKISSLSEYLSLEYLLMSELDFAIGPGFVETGNNIIRELLFEEEAVCIMHKSHP
CCCEEEEEHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCHHHHHHHHHCCCCEEEEECCCC
LANQELTQDMYLQAEHVDIQFSYMGNENILYKALQGYHQRNIKVIVPNIISALEVVYHTN
CCHHHHHHHHHEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
FITTVPRTLAVTFKDRYQIELHPFPFPKKTFLVNFYYHKRLSNHKPLQWVLDVIKKYCCV
HHHHCCCEEEEEECCCEEEEECCCCCCCHHEEEEHHHHHHCCCCCCHHHHHHHHHHHHHC
NHEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12169590 [H]