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The map label for this gene is czcC [H]

Identifier: 52842350

GI number: 52842350

Start: 2382561

End: 2383907

Strand: Reverse

Name: czcC [H]

Synonym: lpg2136

Alternate gene names: 52842350

Gene position: 2383907-2382561 (Counterclockwise)

Preceding gene: 52842351

Following gene: 52842349

Centisome position: 70.16

GC content: 41.2

Gene sequence:

>1347_bases
CTGAAGATAGATAGATTTTTTGAGCTATCGTTTATGGAATATCATCGTGTTTGGCGGTTTTCTTATGGATTAGTCCTGCT
ACTGCTGTATGCCTCTCTGGTATCGGCTGGGAACGCTTTGACTCTTAAAGAAGTAACCCAAATTGCTTTAGCAAACAATA
AGGATTTAAAAGCCGCCCGTTACAATGTATCTATCGCAAAAGCCCGGTTGCTACAAGCAGGCTTTTGGCCTAATCCAAGC
TTGAATCTTTCAAATAATGACGATCGTTTATTCACTGATGAAGGAGAGTATTCGCGCAGTGCTGGCTTTAGCCAGGCATT
TCCCATATCAGGACGTATTGCAAAACAAAAGACAGTGGCTCGTCTGGATGTATTGAAAGCTGTTGCAGAAATCAGGGAAG
CTGAGCGTCAACTCAGTGCCAAAGTGGCTAGTGCCTTTTATACAGCAGTGCTTACAGAGCGTCGCATACAGCAAGTCAAT
TACTTATTACGGATTAACCGGGAATTGGTTGATGTTATCCATAATCGTTATCATGCTGCAGAGATTTCAAAACTGGATGA
CAATGCAGCGCGCATTGAGTATTTGCGTATTGTTCAAGAAAAACATCTTTTGCACAGTCTCAGTATTAGTCAATATGCGA
CACTAAATCAATTAATGGGACGTGAAGCCAACTCTTCTTTATCACTTAAAATGGATTTTGCCGCTGCAAAAAAACTCCCG
GCATTAGATGTTCTAAAAACACAGGCGCTTAAAAATCGCCCTGATCGGCAATCTATTGCGTTATCGATTGAGCGTGCCAA
TGCTGATCGCCGTTTGGCAAAAGCCGAGCGCTTTGCAGATTGGACAGTAGGCCTTGGTATTCAGCAGGATAAAATTGTGG
TGGAAGAAGGCCCCCCTCAACCAGCCGATCGTACTTTGGGCGTCACACTGTCTGTTCCTCTCCCTCTTTTAAATCGAAAT
CAAGGGCGAATTTTAGAAGCAAGTCATACAGGTACTCAGGCGATGATGTCATTACGTGCTCTCGATTTAAGTATTGCAAC
GGAGATAGCCAGTAATTATGAGCAACTCAAAGCATTACGTAAGAGTCTTGAGGAAACACAACGTGTTTCTCTTCAATTAA
CTATTGAAAATGTAAAATTGGCTCGTGATTCTTATGAAAATGGGCAAATTTCTTTTTTAAATGTGCTACAAGTGCAAAAA
CAACAAAACGATTTGCAAACCACTTATCTCAATACGTTAGAAAAATTTTTACAAGTCTATGTGGCCTTGTGTACAGCTAT
TGGTCCTGGAAAAACAGATGGGTTTTGCTCTTATTTAGAGTATCAAAGCAACGGTGATAGCAAATGA

Upstream 100 bases:

>100_bases
AAAAGAAGGTATTAATTGATGACTTACTTTCGAATAAAACACAGTCCATTACTCTTGATGTCTGCACCTGCCACAGATTA
TTTTTTCGATTCCATGTTGA

Downstream 100 bases:

>100_bases
GATTGCAGCTTAAAATTAGAATGATGATCATGACTGTTTTTTTTCTTGGCTTGCTTTCCCCCATCCAAGTGAGTTTTGCA
CACGGAGGAAACATAGAAGT

Product: chemiosmotic efflux system protein C (CzcC)

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKIDRFFELSFMEYHRVWRFSYGLVLLLLYASLVSAGNALTLKEVTQIALANNKDLKAARYNVSIAKARLLQAGFWPNPS
LNLSNNDDRLFTDEGEYSRSAGFSQAFPISGRIAKQKTVARLDVLKAVAEIREAERQLSAKVASAFYTAVLTERRIQQVN
YLLRINRELVDVIHNRYHAAEISKLDDNAARIEYLRIVQEKHLLHSLSISQYATLNQLMGREANSSLSLKMDFAAAKKLP
ALDVLKTQALKNRPDRQSIALSIERANADRRLAKAERFADWTVGLGIQQDKIVVEEGPPQPADRTLGVTLSVPLPLLNRN
QGRILEASHTGTQAMMSLRALDLSIATEIASNYEQLKALRKSLEETQRVSLQLTIENVKLARDSYENGQISFLNVLQVQK
QQNDLQTTYLNTLEKFLQVYVALCTAIGPGKTDGFCSYLEYQSNGDSK

Sequences:

>Translated_448_residues
MKIDRFFELSFMEYHRVWRFSYGLVLLLLYASLVSAGNALTLKEVTQIALANNKDLKAARYNVSIAKARLLQAGFWPNPS
LNLSNNDDRLFTDEGEYSRSAGFSQAFPISGRIAKQKTVARLDVLKAVAEIREAERQLSAKVASAFYTAVLTERRIQQVN
YLLRINRELVDVIHNRYHAAEISKLDDNAARIEYLRIVQEKHLLHSLSISQYATLNQLMGREANSSLSLKMDFAAAKKLP
ALDVLKTQALKNRPDRQSIALSIERANADRRLAKAERFADWTVGLGIQQDKIVVEEGPPQPADRTLGVTLSVPLPLLNRN
QGRILEASHTGTQAMMSLRALDLSIATEIASNYEQLKALRKSLEETQRVSLQLTIENVKLARDSYENGQISFLNVLQVQK
QQNDLQTTYLNTLEKFLQVYVALCTAIGPGKTDGFCSYLEYQSNGDSK
>Mature_448_residues
MKIDRFFELSFMEYHRVWRFSYGLVLLLLYASLVSAGNALTLKEVTQIALANNKDLKAARYNVSIAKARLLQAGFWPNPS
LNLSNNDDRLFTDEGEYSRSAGFSQAFPISGRIAKQKTVARLDVLKAVAEIREAERQLSAKVASAFYTAVLTERRIQQVN
YLLRINRELVDVIHNRYHAAEISKLDDNAARIEYLRIVQEKHLLHSLSISQYATLNQLMGREANSSLSLKMDFAAAKKLP
ALDVLKTQALKNRPDRQSIALSIERANADRRLAKAERFADWTVGLGIQQDKIVVEEGPPQPADRTLGVTLSVPLPLLNRN
QGRILEASHTGTQAMMSLRALDLSIATEIASNYEQLKALRKSLEETQRVSLQLTIENVKLARDSYENGQISFLNVLQVQK
QQNDLQTTYLNTLEKFLQVYVALCTAIGPGKTDGFCSYLEYQSNGDSK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50397; Mature: 50397

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDRFFELSFMEYHRVWRFSYGLVLLLLYASLVSAGNALTLKEVTQIALANNKDLKAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCHHE
YNVSIAKARLLQAGFWPNPSLNLSNNDDRLFTDEGEYSRSAGFSQAFPISGRIAKQKTVA
ECHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCCCCCCHHHHHHHH
RLDVLKAVAEIREAERQLSAKVASAFYTAVLTERRIQQVNYLLRINRELVDVIHNRYHAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EISKLDDNAARIEYLRIVQEKHLLHSLSISQYATLNQLMGREANSSLSLKMDFAAAKKLP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCCC
ALDVLKTQALKNRPDRQSIALSIERANADRRLAKAERFADWTVGLGIQQDKIVVEEGPPQ
HHHHHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHCCHHCCCCCCCCEEEEECCCCC
PADRTLGVTLSVPLPLLNRNQGRILEASHTGTQAMMSLRALDLSIATEIASNYEQLKALR
CCCCEEEEEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLEETQRVSLQLTIENVKLARDSYENGQISFLNVLQVQKQQNDLQTTYLNTLEKFLQVY
HHHHHHHHEEEEEEEEHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VALCTAIGPGKTDGFCSYLEYQSNGDSK
HHHHHCCCCCCCCCHHHHHEECCCCCCC
>Mature Secondary Structure
MKIDRFFELSFMEYHRVWRFSYGLVLLLLYASLVSAGNALTLKEVTQIALANNKDLKAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCHHE
YNVSIAKARLLQAGFWPNPSLNLSNNDDRLFTDEGEYSRSAGFSQAFPISGRIAKQKTVA
ECHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCCCCCCHHHHHHHH
RLDVLKAVAEIREAERQLSAKVASAFYTAVLTERRIQQVNYLLRINRELVDVIHNRYHAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EISKLDDNAARIEYLRIVQEKHLLHSLSISQYATLNQLMGREANSSLSLKMDFAAAKKLP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCCC
ALDVLKTQALKNRPDRQSIALSIERANADRRLAKAERFADWTVGLGIQQDKIVVEEGPPQ
HHHHHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHCCHHCCCCCCCCEEEEECCCCC
PADRTLGVTLSVPLPLLNRNQGRILEASHTGTQAMMSLRALDLSIATEIASNYEQLKALR
CCCCEEEEEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLEETQRVSLQLTIENVKLARDSYENGQISFLNVLQVQKQQNDLQTTYLNTLEKFLQVY
HHHHHHHHEEEEEEEEHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VALCTAIGPGKTDGFCSYLEYQSNGDSK
HHHHHCCCCCCCCCHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]