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The map label for this gene is yqhE [C]

Identifier: 52842279

GI number: 52842279

Start: 2307026

End: 2307868

Strand: Direct

Name: yqhE [C]

Synonym: lpg2065

Alternate gene names: 52842279

Gene position: 2307026-2307868 (Clockwise)

Preceding gene: 52842278

Following gene: 52842280

Centisome position: 67.9

GC content: 36.06

Gene sequence:

>843_bases
ATGAATATAAAACAAAACGACACATCAACCACTCCCCCTATTTTATATGGTACAGCATGGAAAGAAGATGACACAAAACG
TTTGGTGCTCCAGGCACTCAACTCAGGATTTCGAGGGATTGATACTGCCAATCAACGTAGGCATTATTTTGAAGAAGCCG
TGGGTGATGCAATTGATCAATTTTTAACAACTAGTCAAAAAACACGCAGTGATTTATTTCTACAAACAAAATTTACCTCT
GTACATGGCCAAGATCATAGAAAACCTTATGATGAATTTGATTCATTGACCAACCAGGTCAAGCAATCCTTTGCAAGCTC
ACTAGAACATTTACAGACAGACTACATTGACGCCTATATACTTCATGGCCCTTCACTATCTCATGGAATAATCGATGCAG
ATTTAGAAATTTGGCAGGCCATGGAAGAGCTGGTGTGTAGTAGAAAGGTAAAGTTTCTCGGCATTTCTAACGTTAATATG
GTACAAGTTGAAGAACTATATAGAAAAGTCTCTATAAAGCCGTCGTTTATACAAAATAGATGTTTCGCCATAACACAATG
GGATCAAGACGTTAGGACATTTAGTCAAAAAAACAAGATTATCTATCAAGGATTTTCTTTGCTCACTGCGAATCAGCGGT
ATTTATTAAACCCTCACATGCAATCACTTGCTGTAAAATATGATAAAACCATCCCGCAAATTATATTTCGCTTTGCAAAC
CAAGTGGGGATATTGCCTTTAACCGGCACTACAAATCAACAACACATGGATAATGATTTAAACATATATGACTTTGAGCT
TACACAAGAAGAAATTCAATATATAGAAAATATAGGATTATAA

Upstream 100 bases:

>100_bases
TAATGGCTTTGTTCCTTAGCTCATTATCCTCCGAAAAATACCTCTATATTTTGAGGAGGATAATGCTTGGTTATGCTGTG
ACACCAATGGAGGCGGCATT

Downstream 100 bases:

>100_bases
GTGAACCAATATGACCATTAAAATTGAAACACCAAGGATGCTTTTGCGTTTAATTAAGGATGAGGACTTAGATCAAGTTG
CTCAGCTTCATGCAGACCGA

Product: D-xylose reductase III

Products: 2-keto-L-gulonate; NADP [C]

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNIKQNDTSTTPPILYGTAWKEDDTKRLVLQALNSGFRGIDTANQRRHYFEEAVGDAIDQFLTTSQKTRSDLFLQTKFTS
VHGQDHRKPYDEFDSLTNQVKQSFASSLEHLQTDYIDAYILHGPSLSHGIIDADLEIWQAMEELVCSRKVKFLGISNVNM
VQVEELYRKVSIKPSFIQNRCFAITQWDQDVRTFSQKNKIIYQGFSLLTANQRYLLNPHMQSLAVKYDKTIPQIIFRFAN
QVGILPLTGTTNQQHMDNDLNIYDFELTQEEIQYIENIGL

Sequences:

>Translated_280_residues
MNIKQNDTSTTPPILYGTAWKEDDTKRLVLQALNSGFRGIDTANQRRHYFEEAVGDAIDQFLTTSQKTRSDLFLQTKFTS
VHGQDHRKPYDEFDSLTNQVKQSFASSLEHLQTDYIDAYILHGPSLSHGIIDADLEIWQAMEELVCSRKVKFLGISNVNM
VQVEELYRKVSIKPSFIQNRCFAITQWDQDVRTFSQKNKIIYQGFSLLTANQRYLLNPHMQSLAVKYDKTIPQIIFRFAN
QVGILPLTGTTNQQHMDNDLNIYDFELTQEEIQYIENIGL
>Mature_280_residues
MNIKQNDTSTTPPILYGTAWKEDDTKRLVLQALNSGFRGIDTANQRRHYFEEAVGDAIDQFLTTSQKTRSDLFLQTKFTS
VHGQDHRKPYDEFDSLTNQVKQSFASSLEHLQTDYIDAYILHGPSLSHGIIDADLEIWQAMEELVCSRKVKFLGISNVNM
VQVEELYRKVSIKPSFIQNRCFAITQWDQDVRTFSQKNKIIYQGFSLLTANQRYLLNPHMQSLAVKYDKTIPQIIFRFAN
QVGILPLTGTTNQQHMDNDLNIYDFELTQEEIQYIENIGL

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI310109920, Length=306, Percent_Identity=26.1437908496732, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI5453543, Length=306, Percent_Identity=25.8169934640523, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI223468663, Length=300, Percent_Identity=26.3333333333333, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI93277124, Length=308, Percent_Identity=26.6233766233766, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI24497583, Length=307, Percent_Identity=25.7328990228013, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI45446745, Length=306, Percent_Identity=25.8169934640523, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503285, Length=306, Percent_Identity=25.8169934640523, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI291291012, Length=304, Percent_Identity=27.3026315789474, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI310109922, Length=291, Percent_Identity=25.7731958762887, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI5174695, Length=307, Percent_Identity=26.0586319218241, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI24497585, Length=307, Percent_Identity=25.7328990228013, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=23.7931034482759, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=23.7931034482759, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4502049, Length=289, Percent_Identity=27.681660899654, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI300116273, Length=291, Percent_Identity=24.3986254295533, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082198, Length=279, Percent_Identity=25.8064516129032, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17564128, Length=311, Percent_Identity=26.0450160771704, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71998625, Length=243, Percent_Identity=28.3950617283951, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17566692, Length=294, Percent_Identity=25.8503401360544, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17537079, Length=308, Percent_Identity=25.974025974026, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17552492, Length=272, Percent_Identity=25.3676470588235, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562292, Length=258, Percent_Identity=26.3565891472868, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17561298, Length=255, Percent_Identity=27.843137254902, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17537077, Length=296, Percent_Identity=25.6756756756757, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537075, Length=296, Percent_Identity=25, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561300, Length=300, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17550248, Length=302, Percent_Identity=23.5099337748344, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17538386, Length=277, Percent_Identity=23.1046931407942, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320079, Length=261, Percent_Identity=29.1187739463602, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322556, Length=258, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320576, Length=304, Percent_Identity=25, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319625, Length=305, Percent_Identity=24.2622950819672, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129731, Length=294, Percent_Identity=28.2312925170068, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24657054, Length=296, Percent_Identity=29.7297297297297, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24663317, Length=303, Percent_Identity=27.3927392739274, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644950, Length=307, Percent_Identity=26.3843648208469, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=27.7397260273973, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24662789, Length=296, Percent_Identity=26.3513513513513, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356425, Length=275, Percent_Identity=25.0909090909091, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 32384; Mature: 32384

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKQNDTSTTPPILYGTAWKEDDTKRLVLQALNSGFRGIDTANQRRHYFEEAVGDAIDQ
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FLTTSQKTRSDLFLQTKFTSVHGQDHRKPYDEFDSLTNQVKQSFASSLEHLQTDYIDAYI
HHHHCHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
LHGPSLSHGIIDADLEIWQAMEELVCSRKVKFLGISNVNMVQVEELYRKVSIKPSFIQNR
EECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHCC
CFAITQWDQDVRTFSQKNKIIYQGFSLLTANQRYLLNPHMQSLAVKYDKTIPQIIFRFAN
CEEEECCHHHHHHHHHCCCEEEECHHHEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
QVGILPLTGTTNQQHMDNDLNIYDFELTQEEIQYIENIGL
HCCCEEECCCCCHHHCCCCCCEEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MNIKQNDTSTTPPILYGTAWKEDDTKRLVLQALNSGFRGIDTANQRRHYFEEAVGDAIDQ
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FLTTSQKTRSDLFLQTKFTSVHGQDHRKPYDEFDSLTNQVKQSFASSLEHLQTDYIDAYI
HHHHCHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
LHGPSLSHGIIDADLEIWQAMEELVCSRKVKFLGISNVNMVQVEELYRKVSIKPSFIQNR
EECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHCC
CFAITQWDQDVRTFSQKNKIIYQGFSLLTANQRYLLNPHMQSLAVKYDKTIPQIIFRFAN
CEEEECCHHHHHHHHHCCCEEEECHHHEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
QVGILPLTGTTNQQHMDNDLNIYDFELTQEEIQYIENIGL
HCCCEEECCCCCHHHCCCCCCEEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2,5-diketo-D-gluconate; NADPH [C]

Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA