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The map label for this gene is 52842257

Identifier: 52842257

GI number: 52842257

Start: 2283884

End: 2284852

Strand: Reverse

Name: 52842257

Synonym: lpg2040

Alternate gene names: NA

Gene position: 2284852-2283884 (Counterclockwise)

Preceding gene: 52842258

Following gene: 52842256

Centisome position: 67.25

GC content: 37.46

Gene sequence:

>969_bases
TTGACCTCAAGGAGACTAACTATGCATTGGTTTGCTCAGGCACCAGCTAATATTGCTTTGATCAAATATATGGGTAAAAA
GGATGAAAATTCCAATTTACCTGATAATTCTTCTCTATCTTACACCTTGAGTAATTTATTAAGTTCCGTGAAATTAGAGA
AGTTGCCGACTAAAAAAGACATTTGGGAGCCACTTACTATTCCTGGAGCACCAGAATTTAACCTGTCAGTTGAAGCGCAA
AAACGGTTTATTGATCATTTAGTACGATTGAAAGAGTATTTTGGATATGTCGGTGGGTTTTTAATTCAATCCAGTAATAA
TTTCCCTCATAGCAGTGGTTTAGCGAGTTCTGCCTCCAGCTTTGCTGCCTTGACAAAGTGTGCATCAATTGCATTAAGTG
AACTCACTCAAAAACCTTTGCCTTCTATTGATGAGCAAGCACAATTGAGTCGATTAGGTTCAGGCTCATCATGCCGTTCT
TTTTATGCACCATGGGCGTTATGGACGGGCGATAAAGTCTCTGCAATCGATTTGCCTTATAAAGATCTATTACACCAAGT
CATAGTAATTAGCAGTCAGGAAAAAGAAATACCATCAAGGGTAGCGCATAAGCTGGTTAAAACAAGTCCTTTTTATGAAA
CGCGAAGCGAAAGGGCAGAGGCAAATTTGAAGTTGTTACTGAACGCTTTTGAAAACAAAGATTGGACGAGTATATACCAA
ATTTGCTGGCATGAATTTCTTGACATGCATCAATTATTTAAAACCTGTGAAAAACCATTTTCTTACATTACAGATAATAC
TTTGCATATATTGAGCGTTATTGAAAAATTTTGGAACGAGAAAGGTGATGGCCCCGTAGTTACTATGGATGCTGGTCCCA
ATGTTCATTTGCTTTATAGATCAGATCAAACAGATCTCGCACGACAATTTAAATCGGATCATTTGGTAGGAAACTATGAT
GTTTTATGA

Upstream 100 bases:

>100_bases
TAAATCCTACTAATCTTGCAAATTGGATAATTCAGGATAAATTACCAGTTCGTTTTCAACTACAATTACATAAAATTTTA
TGGAATGATGCACCTGGTCA

Downstream 100 bases:

>100_bases
TTTTGAAACCACCACTTTTGGCAAGTGGATTTTAGCAGGTGAACACGCGGTAGTAAGGGGACATGAAGCTTTAGTATTTC
CTATCAAGGAAAGGCAATTA

Product: mevalonate diphosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; GHMP Kinase

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTSRRLTMHWFAQAPANIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLTIPGAPEFNLSVEAQ
KRFIDHLVRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKCASIALSELTQKPLPSIDEQAQLSRLGSGSSCRS
FYAPWALWTGDKVSAIDLPYKDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQ
ICWHEFLDMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLARQFKSDHLVGNYD
VL

Sequences:

>Translated_322_residues
MTSRRLTMHWFAQAPANIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLTIPGAPEFNLSVEAQ
KRFIDHLVRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKCASIALSELTQKPLPSIDEQAQLSRLGSGSSCRS
FYAPWALWTGDKVSAIDLPYKDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQ
ICWHEFLDMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLARQFKSDHLVGNYD
VL
>Mature_321_residues
TSRRLTMHWFAQAPANIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLTIPGAPEFNLSVEAQK
RFIDHLVRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKCASIALSELTQKPLPSIDEQAQLSRLGSGSSCRSF
YAPWALWTGDKVSAIDLPYKDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQI
CWHEFLDMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLARQFKSDHLVGNYDV
L

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=320, Percent_Identity=29.6875, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537201, Length=330, Percent_Identity=23.3333333333333, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324371, Length=317, Percent_Identity=29.9684542586751, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28571205, Length=307, Percent_Identity=29.6416938110749, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 36396; Mature: 36265

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRRLTMHWFAQAPANIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKD
CCCCEEEHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHH
IWEPLTIPGAPEFNLSVEAQKRFIDHLVRLKEYFGYVGGFLIQSSNNFPHSSGLASSASS
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHH
FAALTKCASIALSELTQKPLPSIDEQAQLSRLGSGSSCRSFYAPWALWTGDKVSAIDLPY
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHCCEEEECCCCCEEECCCH
KDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ICWHEFLDMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEE
SDQTDLARQFKSDHLVGNYDVL
CCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TSRRLTMHWFAQAPANIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKD
CCCEEEHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHH
IWEPLTIPGAPEFNLSVEAQKRFIDHLVRLKEYFGYVGGFLIQSSNNFPHSSGLASSASS
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHH
FAALTKCASIALSELTQKPLPSIDEQAQLSRLGSGSSCRSFYAPWALWTGDKVSAIDLPY
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHCCEEEECCCCCEEECCCH
KDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ICWHEFLDMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEE
SDQTDLARQFKSDHLVGNYDVL
CCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA