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The map label for this gene is 52842236

Identifier: 52842236

GI number: 52842236

Start: 2257930

End: 2259618

Strand: Reverse

Name: 52842236

Synonym: lpg2019

Alternate gene names: NA

Gene position: 2259618-2257930 (Counterclockwise)

Preceding gene: 52842237

Following gene: 52842230

Centisome position: 66.5

GC content: 40.91

Gene sequence:

>1689_bases
ATGGGTTTGAAATCAGGAATATTGGGATTAAGTCTTTTATCGCTTGCTTGTGGCAGTTTTGCTATGACTGAAACTGAAAC
AATCAGGGTTATCATTAAATATAAACAGCAACCCGCCACTATTGCTTCACTGAAATCACAAGTCATTAAATCTGTTCAAA
TACCCGTTAAAGAAATGAAGCCTATGGCCAATGGCGCTTATTCGCTTATTTTTGATACATCGAATTCCCATGCTATTGTC
AAGTCTAAAGAAGAAGATGTTACAGCCAAAGTTTTAGAACGTTTGCGCAAAAATCCCAATGTACTTTATGCAGTTAAAGA
CAGAATAGGACATTTTAAGCCTCTCCCTGATCCAGTAATAAACCAGGAGTTAAGTCAATTGTTATCCCATGAGAGTCAAT
GGGATGAATTCGAAAGGCCAGCGGGAATTCGTTTGGAGTCCAGGCCTGGTTTAAGAGATGGCGCATGGGCATATACTACA
GGAAAGTCTAGGAAGCCGATAGTTGTTGCGGTTTTAGATACTGGGATTGCATTGAATGACAGTTTGGTGAATAACCTTGT
AAAAGATAACGAAGGTAATGTATTTGGATGGAATTTTGCCGGGAATAACAATGATTTATCTGATGAAACCAGATCTTACC
ATGGCACCCATGTTGCCGGTACCATTGCCGGTTATGGCGATGTCATGAACGGAGTTGGTGAGGATTTAAAAATTCTGACT
GTTAAAATTCCTGCCGAAAATGGTATGTTTTATGAAAGTGCTGTGGTGAATAGTATCTATTGGGCTGTTGGAGGTGATGT
TCCGGGAGTTCCTAAAAATATACATCCAGCCAAGGTATTAAATATGAGTTTTGGTGTCGATTTAGAGCCTGGAAAAGAAA
TTGATTATTGCGACGAAGCTTTACAAGAGGCTTTATTCTTTGCTCGCAAGAAAGGGGCTGTAGTCGCGGTTGCTGCCGGA
AATGATAATGTTTGGGAACACTATAATGCTCCTGCAGTGTGCAATGGAACGATCAAGGTTGCTTCCACCGGACCAGAAGG
ATTGCGTTCGTACTTTTCAAATTATGGGCCCAGTATAACCCTTGCAGCACCGGGAGGTGATAAGCGTTATGGCACTTCGG
GAGGTATTTTATCTACCGTAAACCCGGGAGGTGGATACAATTCATCAGGCTTTGATTTTTATCAAGGGACGAGTATGGCT
TCGCCTCATGTAGCCGGGGTAGCAGGTTTAATTTTTGCTGTCAGTAATAAGGCTTTGAAACCTGAACAAGTTGAACAAAT
TTTATATGTTACTACGCATGAGTTTGGGCAAAGCAACGACACCAATAAATCTTGTGTCGGCAAAAAACCTTGTGGACATG
GAATATTGGATGCGGATAATGCTGTGCAGGCAGCATTAAATGCTTATGATGTCTTATTCTCAGCGCCTAAAATGATTGCT
CTGGCAACGCATGAATGTGGAGAGAATAGATTAAAACCTGGTAAAAACATCATTAATGACAGTACTGCGACCTGGATTCA
AGCTAAGTCAAGCTGTGAAACTGGTGTAAGCTATCAGAAGCCACGTATTGAAAAAGCCAAGGATGGAAAGATTTATGCTT
ATTATGGTTCCGTAAGCTATGAATTGGATCAATCGGCTTATAAAGAATGTCGTGTCGTTGGATATGATGGCGTAGGCTGT
TACTTATAA

Upstream 100 bases:

>100_bases
TTGATTCTTGAGTTGATATTTATTCTCCTGCATACTGAGGTGGTTTTATTTTTAAAAATTGGTCAAGGCTACGGATTGAC
TTTAAAAAGGAGATTGAAGT

Downstream 100 bases:

>100_bases
TATCAAATGAAACTTGATTCTCAGTTTTAAGACGTTTTGATGAGGGAAGTATTCAGAGCCAATTTATTGGTTACGTATGG
AATCCTTCTCTCATCAAATT

Product: serine metalloprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MGLKSGILGLSLLSLACGSFAMTETETIRVIIKYKQQPATIASLKSQVIKSVQIPVKEMKPMANGAYSLIFDTSNSHAIV
KSKEEDVTAKVLERLRKNPNVLYAVKDRIGHFKPLPDPVINQELSQLLSHESQWDEFERPAGIRLESRPGLRDGAWAYTT
GKSRKPIVVAVLDTGIALNDSLVNNLVKDNEGNVFGWNFAGNNNDLSDETRSYHGTHVAGTIAGYGDVMNGVGEDLKILT
VKIPAENGMFYESAVVNSIYWAVGGDVPGVPKNIHPAKVLNMSFGVDLEPGKEIDYCDEALQEALFFARKKGAVVAVAAG
NDNVWEHYNAPAVCNGTIKVASTGPEGLRSYFSNYGPSITLAAPGGDKRYGTSGGILSTVNPGGGYNSSGFDFYQGTSMA
SPHVAGVAGLIFAVSNKALKPEQVEQILYVTTHEFGQSNDTNKSCVGKKPCGHGILDADNAVQAALNAYDVLFSAPKMIA
LATHECGENRLKPGKNIINDSTATWIQAKSSCETGVSYQKPRIEKAKDGKIYAYYGSVSYELDQSAYKECRVVGYDGVGC
YL

Sequences:

>Translated_562_residues
MGLKSGILGLSLLSLACGSFAMTETETIRVIIKYKQQPATIASLKSQVIKSVQIPVKEMKPMANGAYSLIFDTSNSHAIV
KSKEEDVTAKVLERLRKNPNVLYAVKDRIGHFKPLPDPVINQELSQLLSHESQWDEFERPAGIRLESRPGLRDGAWAYTT
GKSRKPIVVAVLDTGIALNDSLVNNLVKDNEGNVFGWNFAGNNNDLSDETRSYHGTHVAGTIAGYGDVMNGVGEDLKILT
VKIPAENGMFYESAVVNSIYWAVGGDVPGVPKNIHPAKVLNMSFGVDLEPGKEIDYCDEALQEALFFARKKGAVVAVAAG
NDNVWEHYNAPAVCNGTIKVASTGPEGLRSYFSNYGPSITLAAPGGDKRYGTSGGILSTVNPGGGYNSSGFDFYQGTSMA
SPHVAGVAGLIFAVSNKALKPEQVEQILYVTTHEFGQSNDTNKSCVGKKPCGHGILDADNAVQAALNAYDVLFSAPKMIA
LATHECGENRLKPGKNIINDSTATWIQAKSSCETGVSYQKPRIEKAKDGKIYAYYGSVSYELDQSAYKECRVVGYDGVGC
YL
>Mature_561_residues
GLKSGILGLSLLSLACGSFAMTETETIRVIIKYKQQPATIASLKSQVIKSVQIPVKEMKPMANGAYSLIFDTSNSHAIVK
SKEEDVTAKVLERLRKNPNVLYAVKDRIGHFKPLPDPVINQELSQLLSHESQWDEFERPAGIRLESRPGLRDGAWAYTTG
KSRKPIVVAVLDTGIALNDSLVNNLVKDNEGNVFGWNFAGNNNDLSDETRSYHGTHVAGTIAGYGDVMNGVGEDLKILTV
KIPAENGMFYESAVVNSIYWAVGGDVPGVPKNIHPAKVLNMSFGVDLEPGKEIDYCDEALQEALFFARKKGAVVAVAAGN
DNVWEHYNAPAVCNGTIKVASTGPEGLRSYFSNYGPSITLAAPGGDKRYGTSGGILSTVNPGGGYNSSGFDFYQGTSMAS
PHVAGVAGLIFAVSNKALKPEQVEQILYVTTHEFGQSNDTNKSCVGKKPCGHGILDADNAVQAALNAYDVLFSAPKMIAL
ATHECGENRLKPGKNIINDSTATWIQAKSSCETGVSYQKPRIEKAKDGKIYAYYGSVSYELDQSAYKECRVVGYDGVGCY
L

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320775, Length=359, Percent_Identity=27.5766016713092, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324576, Length=338, Percent_Identity=27.2189349112426, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR002884 [H]

Pfam domain/function: PF01483 P_proprotein; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 60478; Mature: 60347

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00583 PFKB_KINASES_1 ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLKSGILGLSLLSLACGSFAMTETETIRVIIKYKQQPATIASLKSQVIKSVQIPVKEMK
CCCCHHHHHHHHHHHHHCCEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCC
PMANGAYSLIFDTSNSHAIVKSKEEDVTAKVLERLRKNPNVLYAVKDRIGHFKPLPDPVI
CCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCHHH
NQELSQLLSHESQWDEFERPAGIRLESRPGLRDGAWAYTTGKSRKPIVVAVLDTGIALND
HHHHHHHHHCCHHHHHHCCCCCCEECCCCCCCCCCEEEECCCCCCCEEEEEECCCCEECH
SLVNNLVKDNEGNVFGWNFAGNNNDLSDETRSYHGTHVAGTIAGYGDVMNGVGEDLKILT
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEEHHHHHHHHHCCCCCEEEEE
VKIPAENGMFYESAVVNSIYWAVGGDVPGVPKNIHPAKVLNMSFGVDLEPGKEIDYCDEA
EEEECCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCHHEEEEECCCCCCCCCCCHHHHHH
LQEALFFARKKGAVVAVAAGNDNVWEHYNAPAVCNGTIKVASTGPEGLRSYFSNYGPSIT
HHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEECCEEEEECCCHHHHHHHHHHCCCEEE
LAAPGGDKRYGTSGGILSTVNPGGGYNSSGFDFYQGTSMASPHVAGVAGLIFAVSNKALK
EECCCCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCC
PEQVEQILYVTTHEFGQSNDTNKSCVGKKPCGHGILDADNAVQAALNAYDVLFSAPKMIA
HHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
LATHECGENRLKPGKNIINDSTATWIQAKSSCETGVSYQKPRIEKAKDGKIYAYYGSVSY
EEECCCCCCCCCCCCCHHCCCCCCEEEECCCHHCCCCCCCCCCCCCCCCEEEEEECCEEE
ELDQSAYKECRVVGYDGVGCYL
EECHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
GLKSGILGLSLLSLACGSFAMTETETIRVIIKYKQQPATIASLKSQVIKSVQIPVKEMK
CCCHHHHHHHHHHHHHCCEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCC
PMANGAYSLIFDTSNSHAIVKSKEEDVTAKVLERLRKNPNVLYAVKDRIGHFKPLPDPVI
CCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCHHH
NQELSQLLSHESQWDEFERPAGIRLESRPGLRDGAWAYTTGKSRKPIVVAVLDTGIALND
HHHHHHHHHCCHHHHHHCCCCCCEECCCCCCCCCCEEEECCCCCCCEEEEEECCCCEECH
SLVNNLVKDNEGNVFGWNFAGNNNDLSDETRSYHGTHVAGTIAGYGDVMNGVGEDLKILT
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEEHHHHHHHHHCCCCCEEEEE
VKIPAENGMFYESAVVNSIYWAVGGDVPGVPKNIHPAKVLNMSFGVDLEPGKEIDYCDEA
EEEECCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCHHEEEEECCCCCCCCCCCHHHHHH
LQEALFFARKKGAVVAVAAGNDNVWEHYNAPAVCNGTIKVASTGPEGLRSYFSNYGPSIT
HHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEECCEEEEECCCHHHHHHHHHHCCCEEE
LAAPGGDKRYGTSGGILSTVNPGGGYNSSGFDFYQGTSMASPHVAGVAGLIFAVSNKALK
EECCCCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCC
PEQVEQILYVTTHEFGQSNDTNKSCVGKKPCGHGILDADNAVQAALNAYDVLFSAPKMIA
HHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
LATHECGENRLKPGKNIINDSTATWIQAKSSCETGVSYQKPRIEKAKDGKIYAYYGSVSY
EEECCCCCCCCCCCCCHHCCCCCCEEEECCCHHCCCCCCCCCCCCCCCCEEEEEECCEEE
ELDQSAYKECRVVGYDGVGCYL
EECHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA