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The map label for this gene is proC

Identifier: 52842232

GI number: 52842232

Start: 2255112

End: 2255900

Strand: Direct

Name: proC

Synonym: lpg2015

Alternate gene names: 52842232

Gene position: 2255112-2255900 (Clockwise)

Preceding gene: 52842231

Following gene: 52842233

Centisome position: 66.37

GC content: 40.68

Gene sequence:

>789_bases
ATGAATATCAGTTTTATTGGTTATGGGAATATGGCGAAAGCAATTGCCTGCCACTTACAAAAGCAAAATAAATACTCATT
GTCAGCTGCCTCACCATCCTTATCTGCGGGCATTAGTAAAGAAAATATTCGCACTCATTACGATAATAAAGAAGTGGCTA
AAGACGCAGACGTCATTATATTGGCAGTAAAACCCGCACAAATGCGTGAGGTAGTCAATGAGATTAACCCTTTTATTTCA
TCAGGTTGCCTTCTAATCTCAGTGGCAGCCGGATTGTCCCTGACCTGGTTTGCCAAATATTGTAAAAAAGGACAAGCGGT
CGTAAGAACCATGCCTAATACCCCGGCTATAGTTGGATTTGCAGCAACATCAATGATTGCAAATGAATTTGTAAACGAGA
AACAAAAAAAATGGGCAGAACAATTATTTTCAAGCATTGGGATTACTGATTGGGTTAAAGATGAAGAAGACATGGACACC
CTGACAGCCCTTTCTGGCAGTGGCCCTGCTTACGTATTTTTGTTTCTTGAAGCGATGATTAATGCAGGGGTCCAATTGGG
CCTGGAAGAAACGGTTGCCAAACACTTTGCCATACAGACATTTTCAGGATCGCTTCAATTAGCTCAACATAGCCAGTTAA
GTTTGACTGAACTGAGAAAAAAAGTAACTTCTCCGGGAGGTACAACAGCCGCAGCTTTGGAAATCCTGCATGGAGATTTG
GATGAGCTCATTTTTTCTGCTATGAAAGCTGCGAAACAAAAAGCTCATGAATTAGGAAAAGTTGAATAA

Upstream 100 bases:

>100_bases
CAATGGGTATGAGTGATGATTTGGTTCCGGCAATTAAAGCAGGTTCGACCATAGTTCGAATTGGACGAGCAATTTTTGGC
GAACGAAAAGGTAAATTATT

Downstream 100 bases:

>100_bases
CACTTTTGAGTTAACAAAAATTCTATCGCAAGAAGTCCTCTGTTGATTTCTTTTATTTTAATGTCAGTCAGGATTTACAA
AAACCCCAAGGTCAAGGCAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDADVIILAVKPAQMREVVNEINPFIS
SGCLLISVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGFAATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDT
LTALSGSGPAYVFLFLEAMINAGVQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
DELIFSAMKAAKQKAHELGKVE

Sequences:

>Translated_262_residues
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDADVIILAVKPAQMREVVNEINPFIS
SGCLLISVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGFAATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDT
LTALSGSGPAYVFLFLEAMINAGVQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
DELIFSAMKAAKQKAHELGKVE
>Mature_262_residues
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDADVIILAVKPAQMREVVNEINPFIS
SGCLLISVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGFAATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDT
LTALSGSGPAYVFLFLEAMINAGVQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
DELIFSAMKAAKQKAHELGKVE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=32.2222222222222, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=32.2222222222222, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=32.089552238806, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=32.2222222222222, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=32.8301886792453, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=30.7116104868914, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320861, Length=226, Percent_Identity=32.7433628318584, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=34.3396226415094, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24647700, Length=167, Percent_Identity=33.5329341317365, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28312; Mature: 28312

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDADVII
CCEEEEECCCHHHHHHHHHHHCCCEEECCCCCCHHCCCCHHHHHHHCCCHHHHCCCCEEE
LAVKPAQMREVVNEINPFISSGCLLISVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGF
EEECCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHH
AATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDTLTALSGSGPAYVFLFLEAMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
NAGVQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
HCCHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCH
DELIFSAMKAAKQKAHELGKVE
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDADVII
CCEEEEECCCHHHHHHHHHHHCCCEEECCCCCCHHCCCCHHHHHHHCCCHHHHCCCCEEE
LAVKPAQMREVVNEINPFISSGCLLISVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGF
EEECCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHH
AATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDTLTALSGSGPAYVFLFLEAMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
NAGVQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
HCCHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCH
DELIFSAMKAAKQKAHELGKVE
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]