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The map label for this gene is rnc

Identifier: 52842090

GI number: 52842090

Start: 2090282

End: 2090956

Strand: Reverse

Name: rnc

Synonym: lpg1869

Alternate gene names: 52842090

Gene position: 2090956-2090282 (Counterclockwise)

Preceding gene: 52842091

Following gene: 52842087

Centisome position: 61.54

GC content: 38.81

Gene sequence:

>675_bases
GTGAAAATTAATTTAGAAAGATTGTGCAGACGTTTAAACTATCATTTTAATAACATAGCCTATTTGAAGCAGGCTTTGAC
GCATTGCAGTGCTGGTAGCGATAATTATGAACGCTTTGAGTTTCTTGGAGATTCGATACTAAGTTTTGTTATTGCCAATG
AGCTATTCAATCGTTTTCCACTTCACAGTGAAGGGCAATTAAGTCGATTGCGTTCTTTTCTTGTTAAAGGTGAAATGTTA
GCAGAAATAGCCAGAGAAATAGATTTGGGTGATTATCTATTTCTTGGGCAAGGTGAGTTAAGGAGCGGTGGATTTCGCCG
CACATCTATATTAGCAGATGCCCTTGAGGCTATATTGGCAGCCATTTATTTGGATGGAGGAATGATTGCTGCAAAACAGA
TTATTTTAATGCTTTATAGTTCACGATTGGATGATCCGGATTTAAATCATTGTTTAAAGGATGCAAAGACACAATTACAG
GAGTTTTTGCAAGCATCAAAATTCGCTTTACCTGAATACGTCCTAACCAAGATTGAGGGGGATGAGCACGCTCAAATCTT
CCATGTAACATGCACAATTGAGGGAGTAAGTCAGGTAGCTTATGGCACAGGGCCTAATAGAAGAAAAGCTGAGCAGTTGG
CAGCAAAAGCCATGTTGGAACAGTTACAAGGTTAA

Upstream 100 bases:

>100_bases
AAATTTAAAATTAAGTTAAAATATCAAGTCATCAAACCTCTAATTTATAATATGAGCTTATTATTTAATTTTGAAGATAA
TTTTGAGGTAATAACAGGTA

Downstream 100 bases:

>100_bases
ATGGTATTGATTAGCAGAACCTATTACTTACTCCAGGTTTTCCAGAGCATTACATATTTCTAACCACTCTTCTTCTGTCT
TCATTAAAGAAGAATGAGCG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIDLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMIAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKIEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG

Sequences:

>Translated_224_residues
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIDLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMIAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKIEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
>Mature_224_residues
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIDLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMIAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKIEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=216, Percent_Identity=31.4814814814815, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI155030236, Length=216, Percent_Identity=31.4814814814815, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI29294649, Length=257, Percent_Identity=27.6264591439689, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI29294651, Length=257, Percent_Identity=27.6264591439689, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1788920, Length=221, Percent_Identity=50.2262443438914, Blast_Score=213, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=29.7777777777778, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=29.7777777777778, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137682, Length=202, Percent_Identity=28.7128712871287, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25206; Mature: 25206

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFP
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LHSEGQLSRLRSFLVKGEMLAEIAREIDLGDYLFLGQGELRSGGFRRTSILADALEAILA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDGGMIAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQEFLQASKFALPEYVLTKIEG
HHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
DEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
CCCCEEEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKINLERLCRRLNYHFNNIAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFP
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LHSEGQLSRLRSFLVKGEMLAEIAREIDLGDYLFLGQGELRSGGFRRTSILADALEAILA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDGGMIAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQEFLQASKFALPEYVLTKIEG
HHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
DEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
CCCCEEEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA