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The map label for this gene is atoB

Identifier: 52842052

GI number: 52842052

Start: 2043750

End: 2044934

Strand: Direct

Name: atoB

Synonym: lpg1825

Alternate gene names: 52842052

Gene position: 2043750-2044934 (Clockwise)

Preceding gene: 52842051

Following gene: 52842053

Centisome position: 60.15

GC content: 44.47

Gene sequence:

>1185_bases
ATGGAACATAATGATGTCGTGATAGTCGCAGCAAAAAGAACACCAATGGGAGCTATGCTAGGCAATTTATCTGCACTTTC
CTCCCCAGAGTTAGGGGCAGTAGCGCATATGGCAGCGTTGTCTCAATCAGGTATTGCTCCGGCAGAAATCGATGAAGTGA
TCAGTGGTTGTGTATTACAAGCTGGTATTGGTCAAGCTCCTGCCAGACAGGCAGCAATAAAAGCAGGCATACCTAATTCG
ACAGGAGCCACGACCATTAATAAAATGTGTGGTTCGGGCATGAAGGCTGTGATGCTTGCGCATGATTTAATTAAGGCAGG
TACAGCTAATGTAATTTTGGCTAGCGGTATGGAAAGTATGAGCAATGCCCCCTATTTATTATCCAAAGCACGAGCAGGAT
ATAGACTGGGTCATGGTGAACTGAAAGATCATATGTTCCTTGATGGATTAGAAGATGCCTATGATAAAGGACAATTAATG
GGGTGTTTCGCTGAAACAACTGCAAAACACTTTAATTTCAGCAGAGAACAACAAGACGAATATGCCTTACGCTCAATGAC
CAAAGCGCTAAAAGCAATAGAGAATGGTGCCTTTCGAGAAGAAATCGCTCCTGTCACCTTAACTACCCGCAAAGGAGATA
TCACGGTTGACGTCGATGAAGGGCCTGAGACAGCCAAACTTGCCAAAATACCTCAGTTAAAACCAGCCTTTCAAGCAGAT
GGTACAGTCACAGCAGCCAATTCAAGTTCTATTTCAGATGGCGCGGCCAGTTTAATTTTAATGAGTGCCTCAAACGCAGA
AAAACGTGGCATTAAGCCCTTGGCAAAAATCATAGCACACGCCAGCCATTCCCAAGCCCCACAATGGTTCACAACCGCTC
CTGTTGATGCAATCCGTAAGGTAATGAACAAAGCGTCATGGAAACAAGATGATGTGGATCTTTTTGAGATTAATGAAGCG
TTTGCAGTAGTAGCGATGGCAGCAATTACTCAGCTTGAATTGAATCCGGAACAAGTCAATATACATGGCGGGGCATGCGC
TTTAGGGCATCCCATTGGTGCTTCAGGAGCTCGCATTCTGGTTACTTTAATGCATGCGCTAAAACACCAGGGTAAAAAAC
GCGGAATAGCTTCTTTATGTATAGGCGGTGGTGAAGCAACAGCTATGGCAATTGAGCTAATTTAA

Upstream 100 bases:

>100_bases
GGGATGCGAAGTTGTATGAAATTGGGGCAGGCACTTCTGAAATAAGAAGAATGCTAATTGGTCGTGAACTTTTTAAAGAA
ACAGCATAAGGAATGAGACA

Downstream 100 bases:

>100_bases
CGGTTAAAGATGACCTGGGTAAAACCTTTATTTTTACCCAGGTTTTTATATTAAAACTGGTTGCTATTTTTATTTGCGAC
CAGATAATGTTTTACCTATC

Product: acyl CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAALSQSGIAPAEIDEVISGCVLQAGIGQAPARQAAIKAGIPNS
TGATTINKMCGSGMKAVMLAHDLIKAGTANVILASGMESMSNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLM
GCFAETTAKHFNFSREQQDEYALRSMTKALKAIENGAFREEIAPVTLTTRKGDITVDVDEGPETAKLAKIPQLKPAFQAD
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRKVMNKASWKQDDVDLFEINEA
FAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARILVTLMHALKHQGKKRGIASLCIGGGEATAMAIELI

Sequences:

>Translated_394_residues
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAALSQSGIAPAEIDEVISGCVLQAGIGQAPARQAAIKAGIPNS
TGATTINKMCGSGMKAVMLAHDLIKAGTANVILASGMESMSNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLM
GCFAETTAKHFNFSREQQDEYALRSMTKALKAIENGAFREEIAPVTLTTRKGDITVDVDEGPETAKLAKIPQLKPAFQAD
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRKVMNKASWKQDDVDLFEINEA
FAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARILVTLMHALKHQGKKRGIASLCIGGGEATAMAIELI
>Mature_394_residues
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAALSQSGIAPAEIDEVISGCVLQAGIGQAPARQAAIKAGIPNS
TGATTINKMCGSGMKAVMLAHDLIKAGTANVILASGMESMSNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLM
GCFAETTAKHFNFSREQQDEYALRSMTKALKAIENGAFREEIAPVTLTTRKGDITVDVDEGPETAKLAKIPQLKPAFQAD
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRKVMNKASWKQDDVDLFEINEA
FAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARILVTLMHALKHQGKKRGIASLCIGGGEATAMAIELI

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=47.6923076923077, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=46.6836734693878, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=40.0510204081633, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=38.2871536523929, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=32.6241134751773, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=29.7435897435897, Blast_Score=131, Evalue=9e-31,
Organism=Escherichia coli, GI87082165, Length=389, Percent_Identity=45.7583547557841, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=49.2307692307692, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1787663, Length=393, Percent_Identity=38.676844783715, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=36, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=29.1764705882353, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=42.0918367346939, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=42.9292929292929, Blast_Score=308, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=40.5128205128205, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17535917, Length=405, Percent_Identity=33.8271604938272, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=30.8235294117647, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=45.2020202020202, Blast_Score=319, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6322031, Length=389, Percent_Identity=35.2185089974293, Blast_Score=182, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=44.3589743589744, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=45.8974358974359, Blast_Score=333, Evalue=9e-92,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=36.2025316455696, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=32.7014218009479, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41215; Mature: 41215

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAALSQSGIAPAEIDEVISGCVLQ
CCCCCEEEEEECCCCHHHHHHCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AGIGQAPARQAAIKAGIPNSTGATTINKMCGSGMKAVMLAHDLIKAGTANVILASGMESM
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLMGCFAETTAKHFNFSREQQDE
CCCCHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHH
YALRSMTKALKAIENGAFREEIAPVTLTTRKGDITVDVDEGPETAKLAKIPQLKPAFQAD
HHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCEEEECCCCCCHHHHHCCCCCCCCCCCC
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRK
CEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
VMNKASWKQDDVDLFEINEAFAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARIL
HHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHEECCCCEEEECCCEEECCCCCCCCHHHHH
VTLMHALKHQGKKRGIASLCIGGGEATAMAIELI
HHHHHHHHHCHHHCCCHHEEECCCCEEEEEEEEC
>Mature Secondary Structure
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAALSQSGIAPAEIDEVISGCVLQ
CCCCCEEEEEECCCCHHHHHHCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AGIGQAPARQAAIKAGIPNSTGATTINKMCGSGMKAVMLAHDLIKAGTANVILASGMESM
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLMGCFAETTAKHFNFSREQQDE
CCCCHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHH
YALRSMTKALKAIENGAFREEIAPVTLTTRKGDITVDVDEGPETAKLAKIPQLKPAFQAD
HHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCEEEECCCCCCHHHHHCCCCCCCCCCCC
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRK
CEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
VMNKASWKQDDVDLFEINEAFAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARIL
HHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHEECCCCEEEECCCEEECCCCCCCCHHHHH
VTLMHALKHQGKKRGIASLCIGGGEATAMAIELI
HHHHHHHHHCHHHCCCHHEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]