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The map label for this gene is clpB

Identifier: 52841977

GI number: 52841977

Start: 1950470

End: 1953046

Strand: Direct

Name: clpB

Synonym: lpg1750

Alternate gene names: 52841977

Gene position: 1950470-1953046 (Clockwise)

Preceding gene: 52841975

Following gene: 52841994

Centisome position: 57.4

GC content: 40.55

Gene sequence:

>2577_bases
ATGCGAATGGACAAACTAACATCAAAGTTTCAAATGGCACTTGCAGATGCCCAATCCCTGGCTTTAGGTAGAGACAATGG
ATTTATAGAACCAGAACATTTAATGAAGGCCTTGCTTGATCAGCAAGGTGGAAGTTGCAGACCTCTTCTCAGTAAAGCGG
GTGTTAATATACCACTATTAAGAACTTTAATTGACCAAGCTCTGGATAAACTACCTAAAGTATCAGGCACCGGAGGAGAT
ATTCACATATCTAATGCATTGAATAGACTACTTAACCTGACTGACAAATTATCGCAACAAAGAAAAGATAACTTTATTTC
AAGCGAGCTTTTTATATTAGCAGCGATAAATGAGGATAGTAACCTTGCAAAAATACTTAAACAAGCCGGGGGTGACAACA
AAGCAATTGAAAAAGCAATTGATGAGTTAAGAGGTGGAGAAACGGTTAATGATCCAAATGCAGAGGAACAGCGACAAGCC
CTTGAAAAATATACACTGGATCTGACTGAACGTGCCGAGCAAGGAAAATTGGATCCAGTTATTGGACGAGATGATGAAAT
CAGACGCACCATCCAGGTATTGCAAAGAAGAACTAAAAATAACCCTGTATTAATAGGTGAACCTGGTGTTGGTAAAACAG
CCATAGTAGAAGGTTTGGCACAACGAATTATTAATGGTGAAGTACCTGAAGGATTAAAGAATAAACGCTTACTGGCGCTG
GACATGGGTGCCTTGATCGCAGGTGCAAAATATCGTGGAGAGTTTGAAGAACGCTTAAAAGGGGTGCTTAATGATTTGGC
AAAACAAGAGGGTCAAATCATATTATTTATTGATGAATTACACACTATGGTTGGCGCTGGCAAGGCTGAAGGAGCTATGG
ATGCCGGGAATATGCTCAAGCCAGCATTAGCTAGAGGTGAATTGCATTGCATTGGGGCTACGACATTAGACGAATACCGA
CAATACATTGAAAAGGATGCTGCCCTTGAACGACGTTTTCAAAAAGTACTGGTCGATGAACCCAGTGTGGAAGACACTAT
CGCTATATTAAGGGGACTTAAGGAACGTTATGAAGTTCACCATGGAGTTGAAATTACAGATCCCGCTTTGGTTGCTGCAG
CAACGCTATCCCATCGTTACATCAGCGACCGTCAACTACCTGATAAAGCCATTGATTTAATTGACGAGGCCGCCAGCTTA
ATCCGGATGGAAATTGATTCAAAACCAGAAAGTATGGATAAACTGGAACGACGCTTGATTCAGCTAAAAATCGAGCGTGA
AGCATTGAAAAAGGAAAATGACGAAGCATCTAAAAAAAGACTTGTTGATTTACAAAAAAGTATCGATGAATTAGAGCAAA
ATTATTCAGACTTAGAAGAAATTTGGAAAGCTGAAAAAGCGACCATGCAAGGGTCCACTCAAATCAAAGAGGCACTTGAG
CAAGCCAAACTGGAAATGGAAACTGCAAGGAGAGCAGGAGATTTAAGTCGTATGTCCGAATTACAATATGGACGTATACC
CGAGTTGGAAAAAAGATTAAGCCAAGTCTCTTCCGTTGATGCTATGGAAACAAAGTTGGTACGCAATAAAGTCACCGAAG
ATGAGATCGCAGAAGTTGTTTCAAAATGGACAGGAATCCCAGTATCTAAAATGATGGAAGGAGAAAAGGAAAAACTGCTG
AAAATGGAAGAAGCTTTGCACAGTAGACTCATTGGCCAGAATGAAGCGGTGGATGCTGTTTCTAATGCCATAAGACGGTC
ACGCGCAGGCCTGTCTGATCCTAATCGTCCAATTGGTTCATTTCTTTTTCTGGGGCCAACTGGTGTGGGAAAAACTGAAC
TATGTAAAGCACTTGCTTCTTTTCTTTTTGATACGGAAGAGGCGATGGTGCGCATTGATATGTCTGAATTTATGGAAAAA
CACTCTGTTGCGCGCTTAATCGGAGCGCCTCCTGGCTATGTAGGATATGAGGAGGGTGGCTATTTAACTGAAGCAGTCAG
ACGCAGACCCTATTCTGTTATCTTACTTGATGAAGTAGAAAAAGCTCATACAGATGTATTTAATATTCTGCTTCAAGTGA
TGGATGATGGCCGTCTAACAGATGGTCAGGGACGTACTGTTGACTTTAGGAATACCGTTATTGTTATGACCTCTAATCTG
GGATCTCAACTCATTCAGGAAATGAGCAGCAAATTTAATTACGATGAGATTAAGGCTGCGGTAATGGATTTAGTCAGCCA
ACATTTCAGGCCTGAATTTATCAACAGAATTGATGAATCGGTGGTATTCCATTCCCTGACAAAAGAACAAATTGCAAAAA
TTGCAGCAATCCAGATTAACTATTTACATCATCGGCTGAAACAACAAAATATCACTATTGAAGTCACAAGTGAGGCTTTA
TCTCATTTGGCTGAAGCAGGTTTTGACCCGGTCTATGGTGCCCGCCCCCTAAAACGTACTATTCAGCAAAAATTAGAGAA
TCCACTAGCTCAATCATTATTGACTGGAAAATTTAAATCCGGGGATACCATTATTGTATCTTATAAAGATGGAGTAATGG
AATTTTACAAGCAATGA

Upstream 100 bases:

>100_bases
CTCATTATTCATAAAAAACTCTTGAAAAATTGTAAATAATACCCATTTTATGGCATGTAAACTAGAATTAATACCCTAAA
ATAACTAGAAAGGTGTTCCT

Downstream 100 bases:

>100_bases
GTATGCTTATCATTGGAAAATAACGCAGGAGTCCTTATCCAGGACTCCAAAATTACGGGGCAATGTTTCAAGACCAAGCT
GGGTAAACATATCAAACAAA

Product: endopeptidase Clp ATP-binding chain B (ClpB)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 858; Mature: 858

Protein sequence:

>858_residues
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITIEVTSEAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGDTIIVSYKDGVMEFYKQ

Sequences:

>Translated_858_residues
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITIEVTSEAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGDTIIVSYKDGVMEFYKQ
>Mature_858_residues
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITIEVTSEAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGDTIIVSYKDGVMEFYKQ

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=323, Percent_Identity=37.1517027863777, Blast_Score=208, Evalue=2e-53,
Organism=Escherichia coli, GI1788943, Length=844, Percent_Identity=75, Blast_Score=1311, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=419, Percent_Identity=40.3341288782816, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320464, Length=705, Percent_Identity=54.3262411347518, Blast_Score=775, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=863, Percent_Identity=43.1054461181924, Blast_Score=693, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95856; Mature: 95856

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCHHHH
RTLIDQALDKLPKVSGTGGDIHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDS
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCH
NLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQALEKYTLDLTERAEQGKLDPV
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLK
EHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCIGATTLDEYRQYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVH
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASLIRMEIDSKPESMDKLERRLI
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SKWTGIPVSKMMEGEKEKLLKMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEKHSVARLIGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCHHHHHEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECCEEEEEECHH
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQIN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLHHRLKQQNITIEVTSEALSHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKS
HHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GDTIIVSYKDGVMEFYKQ
CCEEEEEECHHHHHHHCC
>Mature Secondary Structure
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCHHHH
RTLIDQALDKLPKVSGTGGDIHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDS
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCH
NLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQALEKYTLDLTERAEQGKLDPV
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLK
EHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCIGATTLDEYRQYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVH
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASLIRMEIDSKPESMDKLERRLI
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SKWTGIPVSKMMEGEKEKLLKMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEKHSVARLIGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCHHHHHEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECCEEEEEECHH
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQIN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLHHRLKQQNITIEVTSEALSHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKS
HHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GDTIIVSYKDGVMEFYKQ
CCEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]