Click here to switch to the map view.

The map label for this gene is sppA

Identifier: 52841976

GI number: 52841976

Start: 1949425

End: 1950381

Strand: Reverse

Name: sppA

Synonym: lpg1749

Alternate gene names: 52841976

Gene position: 1950381-1949425 (Counterclockwise)

Preceding gene: 52841978

Following gene: 52841974

Centisome position: 57.4

GC content: 36.99

Gene sequence:

>957_bases
ATGAATAATGAGTCATCTTCTAATTCTAATTTGGATTCACAAGCTTTGCTTAATCAATTGGTAATTGACTATCTCCAAGA
AAGGAAAAGAAAACGTCGATGGAAATGGATTATAAGAGCTATTATCCTGGCCGTATTAGTTTATTCATCTTATAAGATCG
TTTCAGTCGCCAAAACTACGGAAGCATCTAAGGATAAAGAGCATATTGGCCTAATTGATATTAATGGTGAAATTGCTGAT
TCCAGTTCAGCAAGTGCTGATAATTTTACTAAAGGAATTGAGAAGGCTTATAGAAGTAAAGGATTAAAAGCATTAATTGT
ACGGATAAATAGCCCTGGAGGCAGTCCTGTACAGGCCGAATATATTTATAATGTTTTACAATATTACAAAAGCCTAAAAC
CAAACATTAAAACTTACGCTGTTTGTGTCGATATGTGTGCTTCTGCTGCGTATTATGTTGCAGTTGGAGCAGATGAAATC
TATGCAAGTCCTGCAAGCATGGTTGGCTCAATAGGTGTTTTATATAATGGCTTTGGTTTTGTTGATGCATTGCAGAAGCT
TGGTATTTCACGCAGATTACAAACTTCAGGAGTCAATAAAGCTTTCCTGGACCCTTTTTCCCCAACGACTGAATTTCAGA
AAGAAAAGCTACAAACCATGCTTGATATAGTTCATAAGCAATTTATTACTCGTGTCAAAGAAGGAAGAGGAAATAGATTA
CATGTTGATGATGAGACTTTTTCCGGGTTATTTTGGACTGGTGAGCAAGCCTTGGCTAGTGGTTTAATTGATGGTTATGC
CAGTAGCGGGCAGTTGGCGCGAGAGGTAATTAAAATTACTGATATAGTTGACTATACTTACAAGCAAAATGTCTTTGACC
GCCTAACTAAAAATTTGGGCACGGCGATGGCAGATGAGTTGCCAGTAATTTTAGGAATGAAGCCAGGATTAAGATAA

Upstream 100 bases:

>100_bases
GTCCATTCGCATAGGAACACCTTTCTAGTTATTTTAGGGTATTAATTCTAGTTTACATGCCATAAAATGGGTATTATTTA
CAATTTTTCAAGAGTTTTTT

Downstream 100 bases:

>100_bases
GAGTGGAGAGGAGTATTTATCCGCTTTCTCAGCTTCGAGAGAGCGGATATTCGAAAATAATTTAAAATCGATAAGCCTAA
ATGAACGTCTTAAATGAGCT

Product: signal peptide peptidase

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILAVLVYSSYKIVSVAKTTEASKDKEHIGLIDINGEIAD
SSSASADNFTKGIEKAYRSKGLKALIVRINSPGGSPVQAEYIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEI
YASPASMVGSIGVLYNGFGFVDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HVDDETFSGLFWTGEQALASGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLGTAMADELPVILGMKPGLR

Sequences:

>Translated_318_residues
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILAVLVYSSYKIVSVAKTTEASKDKEHIGLIDINGEIAD
SSSASADNFTKGIEKAYRSKGLKALIVRINSPGGSPVQAEYIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEI
YASPASMVGSIGVLYNGFGFVDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HVDDETFSGLFWTGEQALASGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLGTAMADELPVILGMKPGLR
>Mature_318_residues
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILAVLVYSSYKIVSVAKTTEASKDKEHIGLIDINGEIAD
SSSASADNFTKGIEKAYRSKGLKALIVRINSPGGSPVQAEYIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEI
YASPASMVGSIGVLYNGFGFVDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HVDDETFSGLFWTGEQALASGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLGTAMADELPVILGMKPGLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=257, Percent_Identity=28.0155642023346, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787527, Length=237, Percent_Identity=26.5822784810127, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35223; Mature: 35223

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILAVLVYSSYKIVSVAKTT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
EASKDKEHIGLIDINGEIADSSSASADNFTKGIEKAYRSKGLKALIVRINSPGGSPVQAE
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHH
YIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEIYASPASMVGSIGVLYNGFGF
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCHHHHCCHHHHHHHHHHHHCCCCH
VDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HHHHHHCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
HVDDETFSGLFWTGEQALASGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLG
EECCCHHCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAMADELPVILGMKPGLR
HHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILAVLVYSSYKIVSVAKTT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
EASKDKEHIGLIDINGEIADSSSASADNFTKGIEKAYRSKGLKALIVRINSPGGSPVQAE
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHH
YIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEIYASPASMVGSIGVLYNGFGF
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCHHHHCCHHHHHHHHHHHHCCCCH
VDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HHHHHHCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
HVDDETFSGLFWTGEQALASGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLG
EECCCHHCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAMADELPVILGMKPGLR
HHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA