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The map label for this gene is trpE(G) [H]

Identifier: 52841961

GI number: 52841961

Start: 1933935

End: 1936091

Strand: Reverse

Name: trpE(G) [H]

Synonym: lpg1734

Alternate gene names: 52841961

Gene position: 1936091-1933935 (Counterclockwise)

Preceding gene: 52841970

Following gene: 52841960

Centisome position: 56.98

GC content: 38.25

Gene sequence:

>2157_bases
ATGGTATTCATGTTACAGCAATATAAAACTCTCGGTGGTGTTCATGTTGAGTTTTCTCAACAAGAGTTGGATTATCAACA
AGGCATAGATTTTTTGCTTGAGAGCCTTGATTCTCAACGTGGGGCAGTATTTGCTTCGAGCTTTGAATATCCAGGACGCT
ATACTTGTTGGGACATGGGTTTTTATAATCCCCCATTAGTTATCATCTGCCAAAGTAATACCATCTGCTTTGAGGCATTA
AATCAACGAGGCGAGATATTATTATCTTTTCTCTATCCGTTATTAAAAACAACAGATCTCTGGGAGGTAATTAGCCAAAC
GACCTCATTTTGTCAGTTAAAAATTAAATCATCAGACAAAGTATTTAGTGAGGAGGAGCGGAGCCATCAACCGTCAGTAT
TCAGTACAATTCGCCTCTTATTGAATTTTTTTAAAACAGATGAAGATTCATACTTGGGTTTATATGGTGCTTTTGGGTTT
GACCTGATTTATCAATTTGAACAGTTGGAGCGGTGTAAATCAAGAAATGAAACACAGAGAGATATGGTCCTCTATCTACC
TGATGAAATTTATATAGTAAATCATCGTAAGGAAGAAGCCTTTGTTAGACGATATGATTTTCAATATCAGGGGCGATCAA
CTCAATCTTTATCCAGAGAAGGAAAGTATTCACCATATCAACCTATCCATAAACCGGAAAAAAACTGTGATCACGAGCCA
GGTGAATATGCCCAAGTGGTCAAAAAAGCTAAAGAAAAATTTTCCTGTGGTGATTTATTTGAAGTGGTTCCTAGCCAAAC
TTTCTATACTCACTTTGCTGAAAAGCCGTCAATTTTATTTCGCCAAATGCGAGAAATAAATCCATCGCCATATGGATTTT
TTGTTAATTTGGGTGACGAAGAATATCTGGTAGGTGCTTCACCTGAAATGTATGTTCGTGTCCAAGGTAAAAGAGTAGAA
ACTTGCCCTATCTCAGGCACTATCAAACGGGGAGCAGATGCTATTGAGGATGCTCACAATATTCAGACACTTCTAGATTC
AGAGAAAGAAGAATCAGAACTAACCATGTGTACCGATGTGGATAGAAATGATAAGTCAAGAATATGCGAAGCAGGGAGTG
TGAAAGTCATTGGGCGTCGCCAAATTGAAATGTATTCTCGATTGATTCATACAGTTGATCATGTTGAGGGTGTTTTAAGA
GATGGATTTGATGCAGTAGATGCTTTTTTAACTCATATGTGGGTTGTTACTGTGACTGGTGCGCCTAAAATTTGGGCTAT
GAATTTCATTGAACAACATGAGAAATCCCCGCGCAAATGGTATGCAGGAGCCGTAGGATGGTTTGGTTTTGATGGAAATT
TAAATACTGGATTGGTCTTAAGAACAGTGCGAATAGAAAAGGGAACTGCAGAAATTAGAGTAGGCGCAACGTTACTTTAT
GACTCTATTCCTGAAGCTGAGGAAGAGGAGACGAGATTAAAGGCTTCTGCATTTTTAGACATTTTACAAAAACCATGGCA
AAAGGCAAAAAAGAAGATAGAGAATATCCCCCTGGTAGGGGAAAATAAAAAAGTTTTACTTATCGATCATCAAGATTCCT
TTGTTCATACTTTGGCAAACTATTTAAGGCAAACGGGAGCTGCGGTTACAACAGTTCGCTATGACAAGGCGATTGGCTAT
TTACAAAATAATCATTTTGATTTGATCGTATTATCACCTGGCCCTGGAAAACCGGTTGATTTTAAGCTTTCAGAAACAAT
TGATATGATACTCTCAAAGAACATACCAATATTCGGTGTTTGTCTGGGGCTGCAAGGAATTGTTGAGTATTTTGGAGGGG
TTTTGGATGTTCTTGAATACCCTATGCATGGAAAATCTTCAGTAATTAGGGTATTAGATAACAAGGGGTTGTTCTCCGGT
TTAGGCGATTGTTTTAAAGCGGGAAGATACCATTCACTCTATGCCAGAGCAGAGACCTTACCCAGTGAATTATTAGTTAC
CGCTGTAAGTGAAGATGATGTGATTATGGCAGTTTCTCATGAGCATTTACCTGTGCATGCGGTTCAATTTCATCCAGAGA
CAATTTTGTCTTTATCGGATCAAGTGGGTTTAAGAATAATCACCAATTTGATGAATATGGTGAAGGACAATGGGTAA

Upstream 100 bases:

>100_bases
TGAAGACATAAAAAAGCAATGATATTGAAATGTTACAAGATTCTTGCAGAACAGTGGTTTTACAGTAGAATGAATATTTG
TACGAATTAAATGATAGAGA

Downstream 100 bases:

>100_bases
AAAAATACTGATTTTATATTTTGTATCAGTTCTATTAGGGATATTAACAGGCGCAATTGCTTCATTATTCCAACTTACTA
TTCAACAGATGGATCATCTG

Product: anthranilate synthase

Products: NA

Alternate protein names: Glutamine amidotransferase [H]

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MVFMLQQYKTLGGVHVEFSQQELDYQQGIDFLLESLDSQRGAVFASSFEYPGRYTCWDMGFYNPPLVIICQSNTICFEAL
NQRGEILLSFLYPLLKTTDLWEVISQTTSFCQLKIKSSDKVFSEEERSHQPSVFSTIRLLLNFFKTDEDSYLGLYGAFGF
DLIYQFEQLERCKSRNETQRDMVLYLPDEIYIVNHRKEEAFVRRYDFQYQGRSTQSLSREGKYSPYQPIHKPEKNCDHEP
GEYAQVVKKAKEKFSCGDLFEVVPSQTFYTHFAEKPSILFRQMREINPSPYGFFVNLGDEEYLVGASPEMYVRVQGKRVE
TCPISGTIKRGADAIEDAHNIQTLLDSEKEESELTMCTDVDRNDKSRICEAGSVKVIGRRQIEMYSRLIHTVDHVEGVLR
DGFDAVDAFLTHMWVVTVTGAPKIWAMNFIEQHEKSPRKWYAGAVGWFGFDGNLNTGLVLRTVRIEKGTAEIRVGATLLY
DSIPEAEEEETRLKASAFLDILQKPWQKAKKKIENIPLVGENKKVLLIDHQDSFVHTLANYLRQTGAAVTTVRYDKAIGY
LQNNHFDLIVLSPGPGKPVDFKLSETIDMILSKNIPIFGVCLGLQGIVEYFGGVLDVLEYPMHGKSSVIRVLDNKGLFSG
LGDCFKAGRYHSLYARAETLPSELLVTAVSEDDVIMAVSHEHLPVHAVQFHPETILSLSDQVGLRIITNLMNMVKDNG

Sequences:

>Translated_718_residues
MVFMLQQYKTLGGVHVEFSQQELDYQQGIDFLLESLDSQRGAVFASSFEYPGRYTCWDMGFYNPPLVIICQSNTICFEAL
NQRGEILLSFLYPLLKTTDLWEVISQTTSFCQLKIKSSDKVFSEEERSHQPSVFSTIRLLLNFFKTDEDSYLGLYGAFGF
DLIYQFEQLERCKSRNETQRDMVLYLPDEIYIVNHRKEEAFVRRYDFQYQGRSTQSLSREGKYSPYQPIHKPEKNCDHEP
GEYAQVVKKAKEKFSCGDLFEVVPSQTFYTHFAEKPSILFRQMREINPSPYGFFVNLGDEEYLVGASPEMYVRVQGKRVE
TCPISGTIKRGADAIEDAHNIQTLLDSEKEESELTMCTDVDRNDKSRICEAGSVKVIGRRQIEMYSRLIHTVDHVEGVLR
DGFDAVDAFLTHMWVVTVTGAPKIWAMNFIEQHEKSPRKWYAGAVGWFGFDGNLNTGLVLRTVRIEKGTAEIRVGATLLY
DSIPEAEEEETRLKASAFLDILQKPWQKAKKKIENIPLVGENKKVLLIDHQDSFVHTLANYLRQTGAAVTTVRYDKAIGY
LQNNHFDLIVLSPGPGKPVDFKLSETIDMILSKNIPIFGVCLGLQGIVEYFGGVLDVLEYPMHGKSSVIRVLDNKGLFSG
LGDCFKAGRYHSLYARAETLPSELLVTAVSEDDVIMAVSHEHLPVHAVQFHPETILSLSDQVGLRIITNLMNMVKDNG
>Mature_718_residues
MVFMLQQYKTLGGVHVEFSQQELDYQQGIDFLLESLDSQRGAVFASSFEYPGRYTCWDMGFYNPPLVIICQSNTICFEAL
NQRGEILLSFLYPLLKTTDLWEVISQTTSFCQLKIKSSDKVFSEEERSHQPSVFSTIRLLLNFFKTDEDSYLGLYGAFGF
DLIYQFEQLERCKSRNETQRDMVLYLPDEIYIVNHRKEEAFVRRYDFQYQGRSTQSLSREGKYSPYQPIHKPEKNCDHEP
GEYAQVVKKAKEKFSCGDLFEVVPSQTFYTHFAEKPSILFRQMREINPSPYGFFVNLGDEEYLVGASPEMYVRVQGKRVE
TCPISGTIKRGADAIEDAHNIQTLLDSEKEESELTMCTDVDRNDKSRICEAGSVKVIGRRQIEMYSRLIHTVDHVEGVLR
DGFDAVDAFLTHMWVVTVTGAPKIWAMNFIEQHEKSPRKWYAGAVGWFGFDGNLNTGLVLRTVRIEKGTAEIRVGATLLY
DSIPEAEEEETRLKASAFLDILQKPWQKAKKKIENIPLVGENKKVLLIDHQDSFVHTLANYLRQTGAAVTTVRYDKAIGY
LQNNHFDLIVLSPGPGKPVDFKLSETIDMILSKNIPIFGVCLGLQGIVEYFGGVLDVLEYPMHGKSSVIRVLDNKGLFSG
LGDCFKAGRYHSLYARAETLPSELLVTAVSEDDVIMAVSHEHLPVHAVQFHPETILSLSDQVGLRIITNLMNMVKDNG

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=458, Percent_Identity=31.4410480349345, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1788114, Length=352, Percent_Identity=27.2727272727273, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1789760, Length=189, Percent_Identity=36.5079365079365, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1787517, Length=177, Percent_Identity=36.1581920903955, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786809, Length=304, Percent_Identity=26.9736842105263, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87082077, Length=288, Percent_Identity=23.6111111111111, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=277, Percent_Identity=36.4620938628159, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322638, Length=191, Percent_Identity=38.7434554973822, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324361, Length=125, Percent_Identity=32.8, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR006805
- InterPro:   IPR006220
- InterPro:   IPR010112
- InterPro:   IPR001317
- InterPro:   IPR015890
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind; PF00117 GATase [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 81717; Mature: 81717

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00442 GATASE_TYPE_I ; PS00268 CECROPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFMLQQYKTLGGVHVEFSQQELDYQQGIDFLLESLDSQRGAVFASSFEYPGRYTCWDMG
CEEEEEHHHHHCCEEEEECHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECC
FYNPPLVIICQSNTICFEALNQRGEILLSFLYPLLKTTDLWEVISQTTSFCQLKIKSSDK
CCCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCC
VFSEEERSHQPSVFSTIRLLLNFFKTDEDSYLGLYGAFGFDLIYQFEQLERCKSRNETQR
CCCHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DMVLYLPDEIYIVNHRKEEAFVRRYDFQYQGRSTQSLSREGKYSPYQPIHKPEKNCDHEP
CEEEEECCEEEEEECCHHHHHHHHHCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
GEYAQVVKKAKEKFSCGDLFEVVPSQTFYTHFAEKPSILFRQMREINPSPYGFFVNLGDE
CHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCC
EYLVGASPEMYVRVQGKRVETCPISGTIKRGADAIEDAHNIQTLLDSEKEESELTMCTDV
CEEECCCCCEEEEEECCEEEECCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECC
DRNDKSRICEAGSVKVIGRRQIEMYSRLIHTVDHVEGVLRDGFDAVDAFLTHMWVVTVTG
CCCCHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECC
APKIWAMNFIEQHEKSPRKWYAGAVGWFGFDGNLNTGLVLRTVRIEKGTAEIRVGATLLY
CCCHHHHHHHHHHCCCCCHHCCCCCEEEECCCCCCCCEEEEEEEEECCCCEEEECEEEEE
DSIPEAEEEETRLKASAFLDILQKPWQKAKKKIENIPLVGENKKVLLIDHQDSFVHTLAN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
YLRQTGAAVTTVRYDKAIGYLQNNHFDLIVLSPGPGKPVDFKLSETIDMILSKNIPIFGV
HHHHCCCEEEEEEHHHHHHHEECCCEEEEEECCCCCCCCCEEHHHHHHHHHHCCCCEEEH
CLGLQGIVEYFGGVLDVLEYPMHGKSSVIRVLDNKGLFSGLGDCFKAGRYHSLYARAETL
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCC
PSELLVTAVSEDDVIMAVSHEHLPVHAVQFHPETILSLSDQVGLRIITNLMNMVKDNG
CCHHEEEEECCCCEEEEEECCCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVFMLQQYKTLGGVHVEFSQQELDYQQGIDFLLESLDSQRGAVFASSFEYPGRYTCWDMG
CEEEEEHHHHHCCEEEEECHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECC
FYNPPLVIICQSNTICFEALNQRGEILLSFLYPLLKTTDLWEVISQTTSFCQLKIKSSDK
CCCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCC
VFSEEERSHQPSVFSTIRLLLNFFKTDEDSYLGLYGAFGFDLIYQFEQLERCKSRNETQR
CCCHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DMVLYLPDEIYIVNHRKEEAFVRRYDFQYQGRSTQSLSREGKYSPYQPIHKPEKNCDHEP
CEEEEECCEEEEEECCHHHHHHHHHCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
GEYAQVVKKAKEKFSCGDLFEVVPSQTFYTHFAEKPSILFRQMREINPSPYGFFVNLGDE
CHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCC
EYLVGASPEMYVRVQGKRVETCPISGTIKRGADAIEDAHNIQTLLDSEKEESELTMCTDV
CEEECCCCCEEEEEECCEEEECCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECC
DRNDKSRICEAGSVKVIGRRQIEMYSRLIHTVDHVEGVLRDGFDAVDAFLTHMWVVTVTG
CCCCHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECC
APKIWAMNFIEQHEKSPRKWYAGAVGWFGFDGNLNTGLVLRTVRIEKGTAEIRVGATLLY
CCCHHHHHHHHHHCCCCCHHCCCCCEEEECCCCCCCCEEEEEEEEECCCCEEEECEEEEE
DSIPEAEEEETRLKASAFLDILQKPWQKAKKKIENIPLVGENKKVLLIDHQDSFVHTLAN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
YLRQTGAAVTTVRYDKAIGYLQNNHFDLIVLSPGPGKPVDFKLSETIDMILSKNIPIFGV
HHHHCCCEEEEEEHHHHHHHEECCCEEEEEECCCCCCCCCEEHHHHHHHHHHCCCCEEEH
CLGLQGIVEYFGGVLDVLEYPMHGKSSVIRVLDNKGLFSGLGDCFKAGRYHSLYARAETL
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCC
PSELLVTAVSEDDVIMAVSHEHLPVHAVQFHPETILSLSDQVGLRIITNLMNMVKDNG
CCHHEEEEECCCCEEEEEECCCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656657; 11481430 [H]