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The map label for this gene is pyrH

Identifier: 52841940

GI number: 52841940

Start: 1907788

End: 1908531

Strand: Reverse

Name: pyrH

Synonym: lpg1712

Alternate gene names: 52841940

Gene position: 1908531-1907788 (Counterclockwise)

Preceding gene: 161723251

Following gene: 52841939

Centisome position: 56.17

GC content: 42.07

Gene sequence:

>744_bases
ATGATGAATGAAAGTCAACCTAAATTAAAATACAAACGCATTCTGCTTAAATTTAGTGGTGAGGCGCTGATGGGGAAATC
TCAATTTGGGATTGATCCTTCAGTTCTTGACTCATTAGCTCGAGACATAGCAGAATTAATTCATATGGGTGTGGAAGTTG
GTTTGGTTTTAGGTGGAGGTAATCTGTTCAGAGGGAAAGCACTCTCTCAGGCGGGCGTAGGACGAGTGACAGGAGACCAT
ATGGGGATGCTGGCCACTGTTATGAATGCTTTGGCACTCCGTGATGCTTTGGAGCGAATTGATCTGCCTGCTCGTATTAT
GTCAGCTATTCCAATGCTTGGGGTAGTTGACCCATACCATAGAAGAAAAGCTATCACTCACTTGCGCAATGGTCAGGTGG
TGATTTTTGCAGCTGGAACAGGAAATCCCTTTTTTACAACAGATACTGCTGCTTGTTTGAGGGCAATTGAGATAGGCGCA
GATATTGTTTTAAAAGCAACTAAGGTGGATGGAGTTTATTCTGCTGACCCACTTAAAAACTCTGATGCAAAGCGTTATGA
TTATTTGACTTACAAAGAAGTTTTAACCAAAGGTTTGGAAGTGATGGATTCCACTGCAATTTGTTTGTGCCAAGATCAGG
GAATGCCTTTACAGGTGTTTGATATGGCGGCTCCTAAAGCATTAAAACGAATTGTAACTGGAGAACGAGTAGGAACTATA
GTCGGAGCTAATCATGATCAATGA

Upstream 100 bases:

>100_bases
AAAATGCTGAAGTAATATCCTTTGTTCGTTATGAAGTAGGGGAAGGAATAGAGAAAAAAGAGGACAATTTTGTTGAAGAA
GTGATGGCTCAGGTTCGTAC

Downstream 100 bases:

>100_bases
GATTAAGCAAGATTCAGAAAAACGCATGAAAAAGACTATTGAGGCTTTGCATACGGATATGTCAAAAATCCGTACCGGCA
GGGCGAATGCCAGTCTTTTA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MMNESQPKLKYKRILLKFSGEALMGKSQFGIDPSVLDSLARDIAELIHMGVEVGLVLGGGNLFRGKALSQAGVGRVTGDH
MGMLATVMNALALRDALERIDLPARIMSAIPMLGVVDPYHRRKAITHLRNGQVVIFAAGTGNPFFTTDTAACLRAIEIGA
DIVLKATKVDGVYSADPLKNSDAKRYDYLTYKEVLTKGLEVMDSTAICLCQDQGMPLQVFDMAAPKALKRIVTGERVGTI
VGANHDQ

Sequences:

>Translated_247_residues
MMNESQPKLKYKRILLKFSGEALMGKSQFGIDPSVLDSLARDIAELIHMGVEVGLVLGGGNLFRGKALSQAGVGRVTGDH
MGMLATVMNALALRDALERIDLPARIMSAIPMLGVVDPYHRRKAITHLRNGQVVIFAAGTGNPFFTTDTAACLRAIEIGA
DIVLKATKVDGVYSADPLKNSDAKRYDYLTYKEVLTKGLEVMDSTAICLCQDQGMPLQVFDMAAPKALKRIVTGERVGTI
VGANHDQ
>Mature_247_residues
MMNESQPKLKYKRILLKFSGEALMGKSQFGIDPSVLDSLARDIAELIHMGVEVGLVLGGGNLFRGKALSQAGVGRVTGDH
MGMLATVMNALALRDALERIDLPARIMSAIPMLGVVDPYHRRKAITHLRNGQVVIFAAGTGNPFFTTDTAACLRAIEIGA
DIVLKATKVDGVYSADPLKNSDAKRYDYLTYKEVLTKGLEVMDSTAICLCQDQGMPLQVFDMAAPKALKRIVTGERVGTI
VGANHDQ

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=60.7594936708861, Blast_Score=297, Evalue=4e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26661; Mature: 26661

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNESQPKLKYKRILLKFSGEALMGKSQFGIDPSVLDSLARDIAELIHMGVEVGLVLGGG
CCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEEECC
NLFRGKALSQAGVGRVTGDHMGMLATVMNALALRDALERIDLPARIMSAIPMLGVVDPYH
CEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHH
RRKAITHLRNGQVVIFAAGTGNPFFTTDTAACLRAIEIGADIVLKATKVDGVYSADPLKN
HHHHHHHHCCCCEEEEEECCCCCCEECHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
SDAKRYDYLTYKEVLTKGLEVMDSTAICLCQDQGMPLQVFDMAAPKALKRIVTGERVGTI
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHCCCHHEEE
VGANHDQ
ECCCCCC
>Mature Secondary Structure
MMNESQPKLKYKRILLKFSGEALMGKSQFGIDPSVLDSLARDIAELIHMGVEVGLVLGGG
CCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEEECC
NLFRGKALSQAGVGRVTGDHMGMLATVMNALALRDALERIDLPARIMSAIPMLGVVDPYH
CEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHH
RRKAITHLRNGQVVIFAAGTGNPFFTTDTAACLRAIEIGADIVLKATKVDGVYSADPLKN
HHHHHHHHCCCCEEEEEECCCCCCEECHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
SDAKRYDYLTYKEVLTKGLEVMDSTAICLCQDQGMPLQVFDMAAPKALKRIVTGERVGTI
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHCCCHHEEE
VGANHDQ
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA