Click here to switch to the map view.

The map label for this gene is umuC [H]

Identifier: 52841931

GI number: 52841931

Start: 1898621

End: 1899916

Strand: Reverse

Name: umuC [H]

Synonym: lpg1703

Alternate gene names: 52841931

Gene position: 1899916-1898621 (Counterclockwise)

Preceding gene: 52841932

Following gene: 52841928

Centisome position: 55.92

GC content: 39.81

Gene sequence:

>1296_bases
TTGGGGAGTCGTCACTCATGTTATTCATACGGTATTGTGATGTTTGCGCTGGTCGATTGTAATAATTTTTATGTCTCGTG
TGAGCGTTTATTTAAACCAGCCTTAGCGAATAAACCCATTTTGGTCTTGTCTAATAATGATGGTTGTGTGATTGCGCGAT
CTAATGAAGTAAAAGCTTTGGGTGTTCAAATGGGAGTGCCTTATTTTGCAGTCAAAGCATTATGTAAGCAGCATAAAGTG
CATGTGTTTTCATCCAATTACACATTGTATGCTGATATGTCACGCCGGGTTATGTCAGTTCTTGAAGACAATTGGCCAGC
AATAGAGATTTACTCCATTGATGAAGCTTTTCTTGATTTGAATACTTTGCCCCAATCTGAACATGATGAGTTTTGCCGCA
AGTTACAAAAAATTGTTTTGCGCCATACCGGTATTCCCGTATCCATAGGCATAGGGGCAACCAAAACCCTGGCTAAACTC
GCAAACCATATTGCGAAAAAGGAATTAAGAACCCCTGTATTTAACATTGAAAATCAATATCATTGGCTAGCTAAAATAGT
TGTTGGCGAGGTATGGGGGATAGGACGGCAATGGGGTAAAAAGTTAGTACAACAGGGGATTTATACAGCTCATGACTTGG
CTGGTATGGATTTGCAATTAATTAAAAAATTATTTAGTGTTGTATTGCAACGAACAGTGCTTGAGTTGCGTGGGGTTTCA
TGTGGCAGTTTACAGGATTTTGAGTCAAGAAAAAGCATAATATCTTCCAAATCCTTTGGTTCTATGCAAACAGAGTATTC
TGCTCTTGCTCAGGCCATCAGCAGCCATTGTGCCAGAGCTTGGGAAAAGTTACGTCATCAAAAATTGATGGCATGCCATC
TTTCCATATTTATCAAAACCAATCAATTTCGTTTGGATTTGCCACAATATCAGCAAACTATAGGGTTTAAGCTGATTAAT
CCAACTGATGATCTGCGACATTTGATTCGTTGTGCCAAATTGTGCCTGCGTAAAATATTTCGCTCTGGATTCCATTACCA
AAAGGTAGGCGTTTATTTAGGAGATTTAATTGAAAAAAACTGTTTGCAGTTAGATTTGTTTAACCAGGTTTCAGAGAAAG
AATTGAATCAGACAGAGCGATTGATGTCGGTATTAGATGAAATCAACACGAAATATGGCCGCCATACCTTGCGTTTGGCA
GCAGAAGGGCATGTGAAGCCATGGGCTATGCGGGCGCAGTCCCGTTCTCCTCGCTATACAACTTCCTGGTCTGAATTGCC
TGTGGTAATTATTTAA

Upstream 100 bases:

>100_bases
CAGTAAAACGTTTATCCCGTCAACATGGGCAAGTTAAGTTGCTGGCTGAAAACCCTGATTTTCCTCCCATAGATATTACA
GAGGAATACGATATGGTGAT

Downstream 100 bases:

>100_bases
AGAGAAACTGATAGCTATAATGTCATCCGGGAAATCAACTTAAGTCATCCCGGATGATAGCCTGTGTTAATAACCCAGGC
TGGAAATTAATGCCGGACGG

Product: SOS mutagenesis and repair UmuC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MGSRHSCYSYGIVMFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKALCKQHKV
HVFSSNYTLYADMSRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKL
ANHIAKKELRTPVFNIENQYHWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVS
CGSLQDFESRKSIISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQTIGFKLIN
PTDDLRHLIRCAKLCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLA
AEGHVKPWAMRAQSRSPRYTTSWSELPVVII

Sequences:

>Translated_431_residues
MGSRHSCYSYGIVMFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKALCKQHKV
HVFSSNYTLYADMSRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKL
ANHIAKKELRTPVFNIENQYHWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVS
CGSLQDFESRKSIISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQTIGFKLIN
PTDDLRHLIRCAKLCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLA
AEGHVKPWAMRAQSRSPRYTTSWSELPVVII
>Mature_430_residues
GSRHSCYSYGIVMFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKALCKQHKVH
VFSSNYTLYADMSRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKLA
NHIAKKELRTPVFNIENQYHWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVSC
GSLQDFESRKSIISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQTIGFKLINP
TDDLRHLIRCAKLCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLAA
EGHVKPWAMRAQSRSPRYTTSWSELPVVII

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=420, Percent_Identity=48.0952380952381, Blast_Score=367, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 49142; Mature: 49011

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSRHSCYSYGIVMFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKAL
CCCCCCHHHHHHHHHHEEECCCHHEEHHHHHHHHHCCCCEEEEECCCCEEEEECCCCEEE
GVQMGVPYFAVKALCKQHKVHVFSSNYTLYADMSRRVMSVLEDNWPAIEIYSIDEAFLDL
HHHHCCHHHHHHHHHHHCCEEEEECCEEEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHH
NTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKLANHIAKKELRTPVFNIENQY
CCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
HWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVS
HHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
CGSLQDFESRKSIISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKT
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
NQFRLDLPQYQQTIGFKLINPTDDLRHLIRCAKLCLRKIFRSGFHYQKVGVYLGDLIEKN
CCEEECCHHHHHHHCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
CLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLAAEGHVKPWAMRAQSRSPRYT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCCCCC
TSWSELPVVII
CCCCCCCEEEC
>Mature Secondary Structure 
GSRHSCYSYGIVMFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKAL
CCCCCHHHHHHHHHHEEECCCHHEEHHHHHHHHHCCCCEEEEECCCCEEEEECCCCEEE
GVQMGVPYFAVKALCKQHKVHVFSSNYTLYADMSRRVMSVLEDNWPAIEIYSIDEAFLDL
HHHHCCHHHHHHHHHHHCCEEEEECCEEEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHH
NTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKLANHIAKKELRTPVFNIENQY
CCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
HWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVS
HHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
CGSLQDFESRKSIISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKT
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
NQFRLDLPQYQQTIGFKLINPTDDLRHLIRCAKLCLRKIFRSGFHYQKVGVYLGDLIEKN
CCEEECCHHHHHHHCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
CLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLAAEGHVKPWAMRAQSRSPRYT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCCCCC
TSWSELPVVII
CCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]