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The map label for this gene is xasA [C]

Identifier: 52841919

GI number: 52841919

Start: 1884118

End: 1885512

Strand: Direct

Name: xasA [C]

Synonym: lpg1691

Alternate gene names: 52841919

Gene position: 1884118-1885512 (Clockwise)

Preceding gene: 52841918

Following gene: 52841920

Centisome position: 55.45

GC content: 39.64

Gene sequence:

>1395_bases
ATGAATCATTCAAAAAAGGTTCTGAACGTTTTTTCTTTAGTTATGATCAACGTCATTGCTGTAGATAGTTTGAGGACCTT
GCCTATCAGCGCAAAACTTGGATTTTCTCTGGTCTTTTATTATATTTTTGCAGCCCTTACCTTTTTTATTCCAGTAGCAT
TGGTTGCTGCAGAGCTCGCTACCGCCTATCCTAATACCGGCGGAATTTATGTCTGGGTCAGGGAAGCATTCGGGAGACGG
GCAGGATTTATCACTATTTGGCTGCAATGGATCTATAACGTAGTTTGGTATCCAACTATGTTAGCTTTTATCGCCGCCAC
GTTATCCTATTTAATCGCTCCTCATTTGGGGAATAACAAATTTTATTTATTAGGCACAGCACTTACCTTGTTTTGGGTGT
TTACTTTTTTGAATTGCTTTGGCATGAAACTATCCAGCATTGTAAGTATTATCGGCGCCTCCATAGGCACACTACTTCCT
ATGATAGTGATTATTGTCCTGGGCGCAGTTTGGATATTTCAAGATAGACCTGTAGCAGTCAATTACCCCACAACATGGTT
ACCTGATTTTAGTTCTTTAGGAAATCTGTCTTTATTTTCAGCGGTTTTATTTGGCCTTATAGGAATGGAAATGTCTGCTG
TTCATGCTGAAGAAGTAAAAAACCCGCAAAGAGATTATCCAAAAGCACTTTTTTATTCGGCTCTTTTAATTATATCCACC
TTATCATTAGGTTCTTTGGCAATTGTTATTGTAGTACCAAACGATAGTTTAAGTGTTGTGTCAGGCCTTGTTGATGCCTA
CGCCATATTTTTTAATTCCTATAATATGCCGTGGATGACATCAGTGATTGCCGTGTTAATTATTTTAGGAGGCCTCAGTG
GCGTTTCAGCCTGGATAATAGGTCCAACCAAAGGATTACTAGTGTCTGCACGCGATGGTTCCTTACCTGCACTGTTTTCC
CGTGTCAATAAATACGGCTCGCCGGTAGCCATACTGCTCACTCAAGGCGTTATATTTACTGTATTAAGTACAGTCTTTAT
TTTACTCGATTCAATTAATGCTGCGTACTGGGTATTAAGCGATTTAAGTGCTCAAATGGCATTGTTGGTATATATCATGA
TGTTCGCTGCAGCAATTAAATTGCGATACAGCAAGCCCGAACAGCCGCGTGGCTATACTATTCCTGGTGGAAATCTGGTA
ATGTCTCTTATCTCTGGAATTGGGATCATCTGCTGCATAGCTGCTATGATTGTCGGATTTATCCCCCCTTCACAAATCCC
TATAAAGAATGTTTTTCTCTTTGAATGTTTTCTGATCGGCGGCCTTATTCTATTTGTTTTCATTCCCTGGTTATTTGCTA
AAAAACACGACGAGCAATTATGTAGTGAAGAATAA

Upstream 100 bases:

>100_bases
AAACTGTACAGACAAACTTTTCTTTACTCTGTTAACTTATCATAATACCATTTATACCCCATTCAATACCCGGGTTTATT
GCACTCATAAAGGATAAATA

Downstream 100 bases:

>100_bases
TTGAGCAAGAATTGTAAGCCCACAAAAAATTTTGTTGGGCTTTTCAAGATGATTCTTAAAAGTTGTTAATCAATTGTAAT
ATACCCAATAAACTTCAAAC

Product: amino acid antiporter

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNHSKKVLNVFSLVMINVIAVDSLRTLPISAKLGFSLVFYYIFAALTFFIPVALVAAELATAYPNTGGIYVWVREAFGRR
AGFITIWLQWIYNVVWYPTMLAFIAATLSYLIAPHLGNNKFYLLGTALTLFWVFTFLNCFGMKLSSIVSIIGASIGTLLP
MIVIIVLGAVWIFQDRPVAVNYPTTWLPDFSSLGNLSLFSAVLFGLIGMEMSAVHAEEVKNPQRDYPKALFYSALLIIST
LSLGSLAIVIVVPNDSLSVVSGLVDAYAIFFNSYNMPWMTSVIAVLIILGGLSGVSAWIIGPTKGLLVSARDGSLPALFS
RVNKYGSPVAILLTQGVIFTVLSTVFILLDSINAAYWVLSDLSAQMALLVYIMMFAAAIKLRYSKPEQPRGYTIPGGNLV
MSLISGIGIICCIAAMIVGFIPPSQIPIKNVFLFECFLIGGLILFVFIPWLFAKKHDEQLCSEE

Sequences:

>Translated_464_residues
MNHSKKVLNVFSLVMINVIAVDSLRTLPISAKLGFSLVFYYIFAALTFFIPVALVAAELATAYPNTGGIYVWVREAFGRR
AGFITIWLQWIYNVVWYPTMLAFIAATLSYLIAPHLGNNKFYLLGTALTLFWVFTFLNCFGMKLSSIVSIIGASIGTLLP
MIVIIVLGAVWIFQDRPVAVNYPTTWLPDFSSLGNLSLFSAVLFGLIGMEMSAVHAEEVKNPQRDYPKALFYSALLIIST
LSLGSLAIVIVVPNDSLSVVSGLVDAYAIFFNSYNMPWMTSVIAVLIILGGLSGVSAWIIGPTKGLLVSARDGSLPALFS
RVNKYGSPVAILLTQGVIFTVLSTVFILLDSINAAYWVLSDLSAQMALLVYIMMFAAAIKLRYSKPEQPRGYTIPGGNLV
MSLISGIGIICCIAAMIVGFIPPSQIPIKNVFLFECFLIGGLILFVFIPWLFAKKHDEQLCSEE
>Mature_464_residues
MNHSKKVLNVFSLVMINVIAVDSLRTLPISAKLGFSLVFYYIFAALTFFIPVALVAAELATAYPNTGGIYVWVREAFGRR
AGFITIWLQWIYNVVWYPTMLAFIAATLSYLIAPHLGNNKFYLLGTALTLFWVFTFLNCFGMKLSSIVSIIGASIGTLLP
MIVIIVLGAVWIFQDRPVAVNYPTTWLPDFSSLGNLSLFSAVLFGLIGMEMSAVHAEEVKNPQRDYPKALFYSALLIIST
LSLGSLAIVIVVPNDSLSVVSGLVDAYAIFFNSYNMPWMTSVIAVLIILGGLSGVSAWIIGPTKGLLVSARDGSLPALFS
RVNKYGSPVAILLTQGVIFTVLSTVFILLDSINAAYWVLSDLSAQMALLVYIMMFAAAIKLRYSKPEQPRGYTIPGGNLV
MSLISGIGIICCIAAMIVGFIPPSQIPIKNVFLFECFLIGGLILFVFIPWLFAKKHDEQLCSEE

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI115648063, Length=406, Percent_Identity=28.0788177339901, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI115648022, Length=406, Percent_Identity=28.0788177339901, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI186910308, Length=406, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI186910306, Length=406, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI186910304, Length=406, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI33286428, Length=362, Percent_Identity=27.0718232044199, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI9790235, Length=297, Percent_Identity=26.9360269360269, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787768, Length=462, Percent_Identity=30.5194805194805, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI2367353, Length=344, Percent_Identity=27.0348837209302, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87081798, Length=433, Percent_Identity=24.9422632794457, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786602, Length=278, Percent_Identity=23.021582733813, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790575, Length=326, Percent_Identity=25.4601226993865, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789017, Length=369, Percent_Identity=25.4742547425474, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI48994921, Length=474, Percent_Identity=20.464135021097, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082380, Length=257, Percent_Identity=28.0155642023346, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787890, Length=329, Percent_Identity=24.0121580547112, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786908, Length=325, Percent_Identity=22.7692307692308, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=351, Percent_Identity=25.0712250712251, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357367, Length=353, Percent_Identity=24.3626062322946, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550968, Length=346, Percent_Identity=25.4335260115607, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921172, Length=346, Percent_Identity=25.4335260115607, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221331183, Length=305, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647653, Length=305, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664379, Length=305, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1691_LEGPH (P37034)

Other databases:

- EMBL:   AE017354
- EMBL:   L22081
- PIR:   C48642
- RefSeq:   YP_095718.1
- STRING:   P37034
- GeneID:   3078095
- GenomeReviews:   AE017354_GR
- KEGG:   lpn:lpg1691
- eggNOG:   COG0531
- HOGENOM:   HBG514881
- OMA:   YMLMFAS
- ProtClustDB:   CLSK915193
- BioCyc:   LPNE272624:LPG1691-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 50778; Mature: 50778

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdc333b0)-; HASH(0xe8b20ec)-; HASH(0xe6ae2a0)-; HASH(0xf2365d0)-; HASH(0xf3ef5f0)-; HASH(0xf23e914)-; HASH(0xf2bc1c8)-; HASH(0xf2367ec)-; HASH(0xef947f0)-; HASH(0xefe1cc8)-; HASH(0xf244af4)-; HASH(0xefbd8d8)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCH
>Mature Secondary Structure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CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052