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The map label for this gene is purC [H]

Identifier: 52841903

GI number: 52841903

Start: 1863190

End: 1864185

Strand: Reverse

Name: purC [H]

Synonym: lpg1675

Alternate gene names: 52841903

Gene position: 1864185-1863190 (Counterclockwise)

Preceding gene: 52841904

Following gene: 52841902

Centisome position: 54.87

GC content: 39.56

Gene sequence:

>996_bases
ATGCTCATATCTGCTATGAATACCAATGTCCCTAGTCAAGAGGATCTTCTTGCTGCGTTGCCTTTTTGCTTAACCGAAAC
CTCTTTACCTTTCGGCAAAAAGTATAAAGGGAAAGTAAGGGATACCTATGATCTCGGCGATCAATTGATTTTGGTAACTA
CAGATAGACAAAGTGCCTTTGATCGATGCCTTGCTGCTGTACCTTATAAAGGACAAGTATTGAATTTGACTTCAGCATGG
TGGTTTAAAAACACGCAATCGATTGTGCCTAACCATTTAATTGCCGTACCTGATCCCAATGTGGCGATAGCCAAAAAATG
CAAAATATTCCCTATTGAATTTGTTGTTCGTGGGTATATTTCGGGGAGTACAAGTACGTCTTTATGGACGCAATACCAAA
AAGGAGTTCGTGAGTACTGTGGTATAACGTTTCCTGATGGATTAAGAAAAAATCAAAAACTTGAGAGCCCAGTGATAACC
CCCACTACTAAAGAGACGCTCCATGACAGGCCGATTAGCCCACACGAAATCGTCGCAGAAGGCTGGATGACCCAAGAAGA
TTGGGATGAAACCAGCAGTTATGCTTTAAAGTTATTTCAACATGGAATGGAAGTAGCACAGCAACATGGTTTGATTTTGG
TGGATACCAAATATGAATTTGGCCGTGATGCGGAAGGAAGAATTGTATTAGTGGATGAAATTCATACTCCAGATTCCAGT
CGTTATTGGTTATTTAACGGTTATCAAGAGCGATTTGATGCCGGTAAGGAGCCTGAGAATATAGATAAAGAATTTTTGCG
CTTGTGGTTTGTTGATCACTGCGATCCTTATAAGGATGAAGTATTACCTCAAGCACCACAGGAGTTAATTGTTACTTTAG
CATCAAGATATATCCAATTATATGAAATGATTACAGGTGAATCGTTTGTGTATGACAGTAATCCTGGGCCAGTAAATGAT
AGGATTTTGCATAATATACAACGTTGGTTAGGTTAA

Upstream 100 bases:

>100_bases
GCCATACACCATGGTGTTTTGTGGATGTTTAGCAGTGAAAATGTTAAAATACAAGAATTGGCAGAATCCATTTTAGCTAC
TAATATTATCTTTAACCCTA

Downstream 100 bases:

>100_bases
TTTTTAGCCGGGGGAAAGGCTTATGTGTGGCATTGTAGGAATTTACAGTCATGAACCCGTTGCTGCTGAGCTTTATGATA
GCTTGATTCATTTACAGCAC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MLISAMNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSAW
WFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVIT
PTTKETLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSS
RYWLFNGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVND
RILHNIQRWLG

Sequences:

>Translated_331_residues
MLISAMNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSAW
WFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVIT
PTTKETLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSS
RYWLFNGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVND
RILHNIQRWLG
>Mature_331_residues
MLISAMNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSAW
WFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVIT
PTTKETLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSS
RYWLFNGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVND
RILHNIQRWLG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=299, Percent_Identity=34.1137123745819, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 37870; Mature: 37870

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISAMNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAF
CEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
DRCLAAVPYKGQVLNLTSAWWFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYI
HHHHHCCCCCCEEEEEEHHHHHCCCHHHCCCCEEECCCCCEEEHHCCEEEEHHHHHHHHH
SGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETLHDRPISPHEIVAE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHH
GWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCC
RYWLFNGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQL
CEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHH
YEMITGESFVYDSNPGPVNDRILHNIQRWLG
HHHHCCCEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLISAMNTNVPSQEDLLAALPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAF
CEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
DRCLAAVPYKGQVLNLTSAWWFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPIEFVVRGYI
HHHHHCCCCCCEEEEEEHHHHHCCCHHHCCCCEEECCCCCEEEHHCCEEEEHHHHHHHHH
SGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETLHDRPISPHEIVAE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHH
GWMTQEDWDETSSYALKLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCC
RYWLFNGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQL
CEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHH
YEMITGESFVYDSNPGPVNDRILHNIQRWLG
HHHHCCCEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA