Click here to switch to the map view.

The map label for this gene is cyaA

Identifier: 52841720

GI number: 52841720

Start: 1646838

End: 1648163

Strand: Direct

Name: cyaA

Synonym: lpg1490

Alternate gene names: 52841720

Gene position: 1646838-1648163 (Clockwise)

Preceding gene: 52841719

Following gene: 52841721

Centisome position: 48.47

GC content: 37.03

Gene sequence:

>1326_bases
ATGAGTGTATTGTACTATAATCTTAATAACCACTATGCCTCTCATTTTGTTTATTCACCTGAGAAAAGAGCCAATCATGA
TAACAATCCTGAGAAAATTATGAAGAAACCTTTGGATACTACTGAGCAGAATCGCATTGCTGCATTATACGAATTAAAAA
TTCTGGATACACCACCAGATGAAAGATTTGATCGGATTATCCGACTCACTTCGGGCTACTTATCGGTTCCTATTGCCTTT
ATTTCTTTTATTGATTCTGAACACCAATGGTTCAAATCCAGTTGTGGAATAGGTCTTAACAAAATATCCCGTAATGATTC
ATTTTGCCACTATACTATTCAACAAAATAAACCAATGATAATCTCAGACACCTTGTTGGATGAGCGATTTTGCAATAACC
CCTATGTGACTAGTGAACCCAATATTCGTTTTTATGCAGGATTTCCGTTGTCAACAGTTGATGGTTTTAATGTAGGAACA
TTATGTGCAATAGATAAAAAACCACGCAATTTAGATGAGACTGAAATTCAAATTTTAAAAGATTTGGCAACTTTGGCAGA
AGATCAACTCAACCTATTGGATATTTCGCTTCTCGAAAAGTCTGTTCGAGAAAAAAATATCTCTCTGATAAAAGCTAAAA
AAGAACTTGAAATGCGAAATAATTTTATTCGTAAAGTATTTGGTAGTTTTATGTCTGACGAGATTGTTGCAGCGCTTCTT
GAATCAAAATCAGAGTTAAAATTAGGAGGGGAGGAGCGGAAAATTACAATTCTGTTTAGTGATTTACGTAATTTTACTAC
TTTGTCGGAGCACTTTCCTGCTGAGAAAATTGTCGCTGCCCTTAATAATTATTACGGAAAAATGGTTGATGTCATAGAAA
AATACAATGGCACAGTCGATTCCTTTATTGGTGACGCCATTATGGTAGTATTTGGCGCACCACATTCTGGAGGTGATGAC
GCATACCGAGCGATAGCCTGTGCATTAGAGATGCAGGTGATCATGCAAGAGGTGAATGCAATGAACCGTAACAGCAGCTT
GCCTGAATTAGCAATGGGCATAGGGATTAATACAGGTTACGCAATTGTAGGGAACATTGGTTCTCAGAAGCGTATGCAAT
ACAGTGCAATTGGTTCTCCGGTTAATCTGGCATCACGCATTCAGGATCTGACTTTGGGTGGGCAAATTTTAATTTCTGAG
GCAACTTACCAGGAAGTTAATCATTCGCTTGAGTTAAATGGGCATCTCAGAGTAAAAGTTAAGGGAGTTGCTGCTCCTAT
CACTATTTATGATGTAATCGGTTTGAATAAAAAATCAGATTCATAG

Upstream 100 bases:

>100_bases
TATATCCTCCATAATAAGGGTTAGCCACATACAAGTAACCCATAACTTTATTTCCATTGCTAAATACAATTAGCTTATTC
GTTGGTTTAAGCCAATTAAT

Downstream 100 bases:

>100_bases
AAGTAATAATATCACTTTTTAAAATCATGGGGCAAATGGAAAGTTCCAAAAATTCTATACAAATAGTCCAATATTTGCAA
TTTTTGTCATATAAAATGCT

Product: adenylate cyclase PLUS two component hybrid sensor and regulator

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSVLYYNLNNHYASHFVYSPEKRANHDNNPEKIMKKPLDTTEQNRIAALYELKILDTPPDERFDRIIRLTSGYLSVPIAF
ISFIDSEHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMIISDTLLDERFCNNPYVTSEPNIRFYAGFPLSTVDGFNVGT
LCAIDKKPRNLDETEIQILKDLATLAEDQLNLLDISLLEKSVREKNISLIKAKKELEMRNNFIRKVFGSFMSDEIVAALL
ESKSELKLGGEERKITILFSDLRNFTTLSEHFPAEKIVAALNNYYGKMVDVIEKYNGTVDSFIGDAIMVVFGAPHSGGDD
AYRAIACALEMQVIMQEVNAMNRNSSLPELAMGIGINTGYAIVGNIGSQKRMQYSAIGSPVNLASRIQDLTLGGQILISE
ATYQEVNHSLELNGHLRVKVKGVAAPITIYDVIGLNKKSDS

Sequences:

>Translated_441_residues
MSVLYYNLNNHYASHFVYSPEKRANHDNNPEKIMKKPLDTTEQNRIAALYELKILDTPPDERFDRIIRLTSGYLSVPIAF
ISFIDSEHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMIISDTLLDERFCNNPYVTSEPNIRFYAGFPLSTVDGFNVGT
LCAIDKKPRNLDETEIQILKDLATLAEDQLNLLDISLLEKSVREKNISLIKAKKELEMRNNFIRKVFGSFMSDEIVAALL
ESKSELKLGGEERKITILFSDLRNFTTLSEHFPAEKIVAALNNYYGKMVDVIEKYNGTVDSFIGDAIMVVFGAPHSGGDD
AYRAIACALEMQVIMQEVNAMNRNSSLPELAMGIGINTGYAIVGNIGSQKRMQYSAIGSPVNLASRIQDLTLGGQILISE
ATYQEVNHSLELNGHLRVKVKGVAAPITIYDVIGLNKKSDS
>Mature_440_residues
SVLYYNLNNHYASHFVYSPEKRANHDNNPEKIMKKPLDTTEQNRIAALYELKILDTPPDERFDRIIRLTSGYLSVPIAFI
SFIDSEHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMIISDTLLDERFCNNPYVTSEPNIRFYAGFPLSTVDGFNVGTL
CAIDKKPRNLDETEIQILKDLATLAEDQLNLLDISLLEKSVREKNISLIKAKKELEMRNNFIRKVFGSFMSDEIVAALLE
SKSELKLGGEERKITILFSDLRNFTTLSEHFPAEKIVAALNNYYGKMVDVIEKYNGTVDSFIGDAIMVVFGAPHSGGDDA
YRAIACALEMQVIMQEVNAMNRNSSLPELAMGIGINTGYAIVGNIGSQKRMQYSAIGSPVNLASRIQDLTLGGQILISEA
TYQEVNHSLELNGHLRVKVKGVAAPITIYDVIGLNKKSDS

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI50959205, Length=159, Percent_Identity=28.3018867924528, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI148536830, Length=148, Percent_Identity=27.7027027027027, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4557255, Length=167, Percent_Identity=28.7425149700599, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551720, Length=253, Percent_Identity=26.4822134387352, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71989822, Length=230, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71989805, Length=230, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193206632, Length=228, Percent_Identity=29.8245614035088, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212645052, Length=261, Percent_Identity=26.4367816091954, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71995305, Length=249, Percent_Identity=28.1124497991968, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17534655, Length=284, Percent_Identity=26.7605633802817, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561800, Length=255, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561802, Length=248, Percent_Identity=27.8225806451613, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=238, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71995893, Length=209, Percent_Identity=24.8803827751196, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71995895, Length=209, Percent_Identity=24.8803827751196, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71995899, Length=209, Percent_Identity=24.8803827751196, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI161076872, Length=150, Percent_Identity=34.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574512, Length=150, Percent_Identity=34.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330468, Length=259, Percent_Identity=29.3436293436293, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330470, Length=259, Percent_Identity=29.3436293436293, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62484298, Length=171, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI62484477, Length=171, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI116008008, Length=171, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI161078020, Length=246, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583978, Length=153, Percent_Identity=30.718954248366, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24585694, Length=160, Percent_Identity=25.625, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583976, Length=153, Percent_Identity=28.7581699346405, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 49399; Mature: 49268

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLYYNLNNHYASHFVYSPEKRANHDNNPEKIMKKPLDTTEQNRIAALYELKILDTPPD
CEEEEEECCCCEECCEEECCHHHCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECCCCH
ERFDRIIRLTSGYLSVPIAFISFIDSEHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMI
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCCEEEEEEECCCCEE
ISDTLLDERFCNNPYVTSEPNIRFYAGFPLSTVDGFNVGTLCAIDKKPRNLDETEIQILK
EEHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
DLATLAEDQLNLLDISLLEKSVREKNISLIKAKKELEMRNNFIRKVFGSFMSDEIVAALL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESKSELKLGGEERKITILFSDLRNFTTLSEHFPAEKIVAALNNYYGKMVDVIEKYNGTVD
HCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
SFIGDAIMVVFGAPHSGGDDAYRAIACALEMQVIMQEVNAMNRNSSLPELAMGIGINTGY
HHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCE
AIVGNIGSQKRMQYSAIGSPVNLASRIQDLTLGGQILISEATYQEVNHSLELNGHLRVKV
EEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEECCEEEEEE
KGVAAPITIYDVIGLNKKSDS
ECEECCEEEEEEECCCCCCCC
>Mature Secondary Structure 
SVLYYNLNNHYASHFVYSPEKRANHDNNPEKIMKKPLDTTEQNRIAALYELKILDTPPD
EEEEEECCCCEECCEEECCHHHCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECCCCH
ERFDRIIRLTSGYLSVPIAFISFIDSEHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMI
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCCEEEEEEECCCCEE
ISDTLLDERFCNNPYVTSEPNIRFYAGFPLSTVDGFNVGTLCAIDKKPRNLDETEIQILK
EEHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
DLATLAEDQLNLLDISLLEKSVREKNISLIKAKKELEMRNNFIRKVFGSFMSDEIVAALL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESKSELKLGGEERKITILFSDLRNFTTLSEHFPAEKIVAALNNYYGKMVDVIEKYNGTVD
HCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
SFIGDAIMVVFGAPHSGGDDAYRAIACALEMQVIMQEVNAMNRNSSLPELAMGIGINTGY
HHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCE
AIVGNIGSQKRMQYSAIGSPVNLASRIQDLTLGGQILISEATYQEVNHSLELNGHLRVKV
EEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEECCEEEEEE
KGVAAPITIYDVIGLNKKSDS
ECEECCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]