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The map label for this gene is glpK [H]

Identifier: 52841644

GI number: 52841644

Start: 1559774

End: 1561249

Strand: Direct

Name: glpK [H]

Synonym: lpg1414

Alternate gene names: 52841644

Gene position: 1559774-1561249 (Clockwise)

Preceding gene: 52841642

Following gene: 52841646

Centisome position: 45.91

GC content: 40.38

Gene sequence:

>1476_bases
ATGAACTATATACTAGCTATTGACCAGGGAACAAGTAGTACTCGCGCTATGATCTACACCCTTCAAGGTGATTTAATCGC
AAATAGTCAGTATCCTCTTACTCAATATTACCCCAATTCGGGTTGGGTAGAACACGATCCTGAGGAAATATGGCAAAAAA
CTCTGAATGCGATGAGGGATGTCGTATCTCAAGTTCAAGGAAAAGCAATTTTATGCTGTGGCCTTACCAACCAACGGGAA
ACTACTCTGATTTGGAACAAAAAAACAGGGGAATGCCTCGCGCCAGCTATTGTGTGGCAAGATAGACGTACGGAGGAGTT
TTGTTATTCCTTGTCTGAATACTCGTCAATGATACAAGAGAAAACCGGATTACTTCCTGATCCCTATTTTTCAGCGAGCA
AGTTAAACTGGTTACTAAAGAATAATGCTCAAGCTCAATCACTAATTAACCAGGGGGATTTGGCATTTGGGACAATAGAC
AGTTTTTTAATATGGCGCATGACTAAAGGTGCAAGTCATGCTACCGATATCACCAACGCATCCAGAACTATGCTGTTTAA
TATTCATGATGAAAAATGGGATAAGCAGTTGCTGGAGCTTTTTTCTATTTCAGAATCGGTATTACCAGCGGTATACTCCA
GTGATAATCATTTTGGGGTGATAGATAAAGAATGGCTGGGAGTAGAAATACCAATTACCGGGGTTGCAGGTGATCAACAA
GCCGCTTTAATTGGACAAGGTTGTTTTAATGGAGGAATGGTTAAGGCTACTTTTGGTACGGGGGGATTTTTATTACTCAA
TACAGGTGATAAACCAGTTTTCTCAAAGCATAAATTGTTGACTACTATTGCCTATAAAATTAAAGAAAAAACAGTATATG
GTTTGGAGGGTAGTATTTATCATGCCGGAACTACTGTTAAATGGTTACGCGATGAAATGAAGTTGATATCTCATTCTGCT
GAAACTGAAGTATTGGCTCGAAGTCTTGATAGCAATAACGGCGTATATCTTGTTTCATCTTTTACTGGTCTGGGAGCACC
TCATTGGTTATCAATAACGGGAACAGCCATTATAGGTGTATCCCGTTCAACGAATAGAGCACATTTTGCCAGGGCTGCCT
TGGAAGGAGTTTGTTATCAAACACGTGATGTATTAACCTGTATGAGAGATGATAGTCAATTGGATTTGACTTTATTAAGA
GCGGATGGAGGGATGGCAGTAAACCAATGGTTTCTACAATTTATGGCTGATCAGTGCCAGTTGACAATTCAAAAACCCAA
AGACATTGAAACGACTGCCAAAGGGGCAGCAGTATTAGCGGCAATAGGTTCTGGACTATTTGATTCAGTTTCTTCAGTAA
ATAAGATATGGGACGTTGAGAACGAGTTTCAGCCATTCAGGGAAAGAGAGGTAGTTGAAAAAGATTTTCGCGGCTGGCTA
GAGGCGTTGTCAATGGTTAAAGCAAGGCATGCATAG

Upstream 100 bases:

>100_bases
GCCTCCACCAATAATTGCAACATCAAAAACCTGATCCATGTTTTTATCTCCGAAAAAAGATTACACTCAATATCTATAAA
TATAGAGGGATTTTACAATA

Downstream 100 bases:

>100_bases
CCTAGTCTTGTATATAAATTGGTGCGATTAAATTAGATTGCAGTAGCTCGTATTATAGTTTAATACAAGCTACTGATTAA
CACATTGGATTTTTTATTTT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPAVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKIWDVENEFQPFREREVVEKDFRGWL
EALSMVKARHA

Sequences:

>Translated_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPAVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKIWDVENEFQPFREREVVEKDFRGWL
EALSMVKARHA
>Mature_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPAVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKIWDVENEFQPFREREVVEKDFRGWL
EALSMVKARHA

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=442, Percent_Identity=44.7963800904977, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI189409120, Length=442, Percent_Identity=44.7963800904977, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI42794763, Length=447, Percent_Identity=44.2953020134228, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI41393575, Length=442, Percent_Identity=44.3438914027149, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI88196792, Length=501, Percent_Identity=31.7365269461078, Blast_Score=278, Evalue=1e-74,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=44.2190669371197, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1789987, Length=486, Percent_Identity=24.6913580246914, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1789168, Length=493, Percent_Identity=24.3407707910751, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790005, Length=472, Percent_Identity=23.728813559322, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17535599, Length=447, Percent_Identity=38.7024608501119, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI71986140, Length=511, Percent_Identity=23.091976516634, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71986147, Length=287, Percent_Identity=26.4808362369338, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=484, Percent_Identity=33.2644628099174, Blast_Score=256, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17864214, Length=458, Percent_Identity=41.4847161572052, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24655555, Length=452, Percent_Identity=37.6106194690265, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24655560, Length=452, Percent_Identity=37.6106194690265, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24655570, Length=452, Percent_Identity=37.6106194690265, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24655574, Length=452, Percent_Identity=37.6106194690265, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24655565, Length=452, Percent_Identity=37.6106194690265, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24654573, Length=383, Percent_Identity=43.6031331592689, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI19922058, Length=520, Percent_Identity=28.8461538461538, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24652871, Length=487, Percent_Identity=28.952772073922, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21357867, Length=523, Percent_Identity=27.3422562141491, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24656367, Length=508, Percent_Identity=27.1653543307087, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24656372, Length=371, Percent_Identity=28.3018867924528, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI45552909, Length=286, Percent_Identity=29.020979020979, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54594; Mature: 54594

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCCHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESVLPAVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCC
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIY
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCEEECCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKIWDVENEFQPFREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHH
EALSMVKARHA
HHHHHHHHCCC
>Mature Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCCHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESVLPAVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCC
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIY
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCEEECCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKIWDVENEFQPFREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHH
EALSMVKARHA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA