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The map label for this gene is adk

Identifier: 52841641

GI number: 52841641

Start: 1557151

End: 1557861

Strand: Direct

Name: adk

Synonym: lpg1411

Alternate gene names: 52841641

Gene position: 1557151-1557861 (Clockwise)

Preceding gene: 52841640

Following gene: 52841642

Centisome position: 45.83

GC content: 41.21

Gene sequence:

>711_bases
ATGTTACTATATTTGAAAGTATATAATGATTACGAATTATTTAAGGAGTTTTGGATGCGATTAATGCTTTTAGGTGGACC
GGGAGCCGGCAAAGGAACCCAAGCTTCACTTTTAATTAACCGTTATAAAATTCCTCAAATTTCTACCGGTGACATGCTGC
GTGCTGCCATAGCAAAAGGTACGCCCTTAGGATTAAGTGCCCAAAAAATCATGGAATCAGGTGGGTTGGTGTCCGATGAT
ATTATTATCGGGTTAGTGAAGGAAAGACTAAAAAACCCTGATTGTGATAGAGGATTCCTGTTTGATGGTTTTCCAAGAAC
ATTGGTCCAGGCCGAAGCTTTAAAAGATGCAGAAATCCATTTGGATCATGTGATAGAAATAGCCGTCGATGACGAAGAAA
TAATTGAACGCATCAGCGGGCGACGCATTCACCAGCCTTCTGGTAGGGTTTATCACGTTGTGAATCAACCGCCGAAAAAT
CCGGGTGTAGATGACATCACAGGTGAGCCTCTGATTCAACGTGATGATGATAAAGAAGAAACCATACGTAAGCGCTTACA
GGTTTACCATAGCCAAACAGCGCCATTGGTGCAATATTATAAGGAATGGGCTGAATCTGGCTCTAAAGAAGCTCCAAAAT
TTCACACTATTAGTGGTACAGGTACAGTAGAGCAAATATTTGACAACATCGTAACGATACTCGAAACTTAG

Upstream 100 bases:

>100_bases
ACCTGTTTTTTGAGCTGCTCATTTAGTTTTTTAAGACTATGCATGACCAAAATTATTTGTCAATGTGCACTAAATAATTA
TAAAATTTTATAGTGCTACT

Downstream 100 bases:

>100_bases
GAGTTAACATGCCGACCCAGACTATTAACAGCGCTGAATTTGAATCATTAATTAATGACAATGAGATAGTTTTTATTGAT
TTCTGGGCTGAGTGGTGTGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MLLYLKVYNDYELFKEFWMRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDD
IIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKN
PGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVEQIFDNIVTILET

Sequences:

>Translated_236_residues
MLLYLKVYNDYELFKEFWMRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDD
IIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKN
PGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVEQIFDNIVTILET
>Mature_236_residues
MLLYLKVYNDYELFKEFWMRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDD
IIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKN
PGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVEQIFDNIVTILET

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=50.531914893617, Blast_Score=195, Evalue=2e-50,
Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=50.531914893617, Blast_Score=195, Evalue=2e-50,
Organism=Homo sapiens, GI19923437, Length=218, Percent_Identity=42.6605504587156, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI310110345, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI53832003, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI8051579, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI53832001, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22749187, Length=195, Percent_Identity=29.7435897435897, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI28144897, Length=223, Percent_Identity=29.5964125560538, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI28144899, Length=223, Percent_Identity=29.5964125560538, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=26.9058295964126, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=30.2158273381295, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=30.2158273381295, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=55.0925925925926, Blast_Score=246, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=46.8085106382979, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=219, Percent_Identity=32.8767123287671, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=30.8755760368664, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=50.990099009901, Blast_Score=206, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=217, Percent_Identity=44.2396313364055, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=26.6304347826087, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=53.551912568306, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17647141, Length=217, Percent_Identity=28.110599078341, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24663208, Length=215, Percent_Identity=28.3720930232558, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=23.7837837837838, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=23.7837837837838, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 26518; Mature: 26518

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYLKVYNDYELFKEFWMRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKG
CEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCCCHHHHHHHHCC
TPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIH
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEE
LDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDKEE
EEEEEEEEECHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHH
TIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVEQIFDNIVTILET
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLYLKVYNDYELFKEFWMRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKG
CEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCCCHHHHHHHHCC
TPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIH
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEE
LDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDKEE
EEEEEEEEECHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHH
TIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVEQIFDNIVTILET
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA