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The map label for this gene is lpxB

Identifier: 52841601

GI number: 52841601

Start: 1517292

End: 1518446

Strand: Reverse

Name: lpxB

Synonym: lpg1371

Alternate gene names: 52841601

Gene position: 1518446-1517292 (Counterclockwise)

Preceding gene: 52841602

Following gene: 52841600

Centisome position: 44.69

GC content: 38.87

Gene sequence:

>1155_bases
ATGCCGAATGCTAGTCGTGTTGTCATAGTGGCAGGCGAAGAATCTGGTGACCACCATGCTGCCGAGCTGGTAAAGCAATT
AAAAGCAGTTTATCCAGACCTGGAAATTAGTGGCATTGGCGGTAAACACTTAAGAGCCGCTGGGGTTCATTTAATTTCAG
ATTTAACGCGTTATGCCGTAACCGGTTTGACTGAAATAATTCCTTTCCTGAAAATATTCCGTAAAGCCTTTCAGGATATC
AAACAGCATCTGAGTACACAAAAACCTGATTTGCTGATTTTGGTAGATTACCCTGCTTTCAATTTGAGATTGGCCAAGTA
TGCAAAGAAAAAACTGGGAATCAAAATCATTTATTACATCAGCCCTCAAATATGGGCATGGAAAGGCAAACGTATCCATC
TTATTAAAGATTGCATCGATAAAATGGCTGTCATCTTCCCATTTGAAAAGACTATCTATGAAAATGCAGGTGTTCCTGTC
AGTTTTGTAGGACATCCTTTAGTAAAAAAGATAGCTGCTGCCAAGGATAAACACTCGGGCAGAACTTCCTTGGGATTACC
TTTAAATGAGCCAATTATTGCCTTACTGCCTGGGAGTCGCCATTCTGAAATTGAACGCCATATACCGATATTGGTGAATA
CAGCAAAATTGCTGACCCTAGACAACCCCAAACTTCGATTTGTAGTCCCTATCGCTGGAACTATCAATCCTGATAAAGTA
AAAGCTTATTTCAGCAACCAGAATCTTACTGTTACTTTTATCCAGGGACAGGCAATAGAATGCATGTCTGCTGCTGACTT
TGTCATAGTAGCTTCTGGAACTGCCTCATTAGAATGTGCCTTATTGGAAAAACCAATGTGCATTATTTACAAATCGTCCT
TTCTTACTTATGTTGCTGCCATGTATTTTATTAAAGTTAAATTTTTGGGCTTATGTAATCTGTTAGCCAATAAAATGATG
GTACCTGAATTTTTGCAATACGATTGCAATGCAATTGAATTATCTAGATATATTTCCAATTTTCATAATGATCCCAACCA
AGCCAAGTCGATGATTAATCAACTGGCAAAGTTAAAGGAATCTCTGTCTTCCAGCCAGGCTGACTGTTCTCTCTTTGATC
TTGTAGTGGCAGAATTGCCTGAAAAAAATGCATAG

Upstream 100 bases:

>100_bases
AATGATAGCGTGCCGCTTGTTACAGGTGAAGAAGGAAGGGATGCTTTGAAAACAGCTGAACAAATCACCGCTTTAATTAA
TAATAACCTTGTAGAACGCT

Downstream 100 bases:

>100_bases
TTTTGATATGAAAATCTAGATTATCATTTAGCCTTCATGTACAATTAATTTTGCTTTCATTTACATGTGTAAGCAATTGG
ACTGTATGATTTAATTAAAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MPNASRVVIVAGEESGDHHAAELVKQLKAVYPDLEISGIGGKHLRAAGVHLISDLTRYAVTGLTEIIPFLKIFRKAFQDI
KQHLSTQKPDLLILVDYPAFNLRLAKYAKKKLGIKIIYYISPQIWAWKGKRIHLIKDCIDKMAVIFPFEKTIYENAGVPV
SFVGHPLVKKIAAAKDKHSGRTSLGLPLNEPIIALLPGSRHSEIERHIPILVNTAKLLTLDNPKLRFVVPIAGTINPDKV
KAYFSNQNLTVTFIQGQAIECMSAADFVIVASGTASLECALLEKPMCIIYKSSFLTYVAAMYFIKVKFLGLCNLLANKMM
VPEFLQYDCNAIELSRYISNFHNDPNQAKSMINQLAKLKESLSSSQADCSLFDLVVAELPEKNA

Sequences:

>Translated_384_residues
MPNASRVVIVAGEESGDHHAAELVKQLKAVYPDLEISGIGGKHLRAAGVHLISDLTRYAVTGLTEIIPFLKIFRKAFQDI
KQHLSTQKPDLLILVDYPAFNLRLAKYAKKKLGIKIIYYISPQIWAWKGKRIHLIKDCIDKMAVIFPFEKTIYENAGVPV
SFVGHPLVKKIAAAKDKHSGRTSLGLPLNEPIIALLPGSRHSEIERHIPILVNTAKLLTLDNPKLRFVVPIAGTINPDKV
KAYFSNQNLTVTFIQGQAIECMSAADFVIVASGTASLECALLEKPMCIIYKSSFLTYVAAMYFIKVKFLGLCNLLANKMM
VPEFLQYDCNAIELSRYISNFHNDPNQAKSMINQLAKLKESLSSSQADCSLFDLVVAELPEKNA
>Mature_383_residues
PNASRVVIVAGEESGDHHAAELVKQLKAVYPDLEISGIGGKHLRAAGVHLISDLTRYAVTGLTEIIPFLKIFRKAFQDIK
QHLSTQKPDLLILVDYPAFNLRLAKYAKKKLGIKIIYYISPQIWAWKGKRIHLIKDCIDKMAVIFPFEKTIYENAGVPVS
FVGHPLVKKIAAAKDKHSGRTSLGLPLNEPIIALLPGSRHSEIERHIPILVNTAKLLTLDNPKLRFVVPIAGTINPDKVK
AYFSNQNLTVTFIQGQAIECMSAADFVIVASGTASLECALLEKPMCIIYKSSFLTYVAAMYFIKVKFLGLCNLLANKMMV
PEFLQYDCNAIELSRYISNFHNDPNQAKSMINQLAKLKESLSSSQADCSLFDLVVAELPEKNA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=327, Percent_Identity=34.8623853211009, Blast_Score=209, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42635; Mature: 42503

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNASRVVIVAGEESGDHHAAELVKQLKAVYPDLEISGIGGKHLRAAGVHLISDLTRYAV
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
TGLTEIIPFLKIFRKAFQDIKQHLSTQKPDLLILVDYPAFNLRLAKYAKKKLGIKIIYYI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEEE
SPQIWAWKGKRIHLIKDCIDKMAVIFPFEKTIYENAGVPVSFVGHPLVKKIAAAKDKHSG
CCEEEEECCCEEHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCC
RTSLGLPLNEPIIALLPGSRHSEIERHIPILVNTAKLLTLDNPKLRFVVPIAGTINPDKV
CCEECCCCCCCEEEEECCCCHHHHHHCCCEEEEEEEEEEECCCCEEEEEEECCCCCHHHE
KAYFSNQNLTVTFIQGQAIECMSAADFVIVASGTASLECALLEKPMCIIYKSSFLTYVAA
EEEEECCCEEEEEECCCCEECCCCCCEEEEECCCCCEEEEECCCCEEEEEHHHHHHHHHH
MYFIKVKFLGLCNLLANKMMVPEFLQYDCNAIELSRYISNFHNDPNQAKSMINQLAKLKE
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLSSSQADCSLFDLVVAELPEKNA
HHCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PNASRVVIVAGEESGDHHAAELVKQLKAVYPDLEISGIGGKHLRAAGVHLISDLTRYAV
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
TGLTEIIPFLKIFRKAFQDIKQHLSTQKPDLLILVDYPAFNLRLAKYAKKKLGIKIIYYI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEEE
SPQIWAWKGKRIHLIKDCIDKMAVIFPFEKTIYENAGVPVSFVGHPLVKKIAAAKDKHSG
CCEEEEECCCEEHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCC
RTSLGLPLNEPIIALLPGSRHSEIERHIPILVNTAKLLTLDNPKLRFVVPIAGTINPDKV
CCEECCCCCCCEEEEECCCCHHHHHHCCCEEEEEEEEEEECCCCEEEEEEECCCCCHHHE
KAYFSNQNLTVTFIQGQAIECMSAADFVIVASGTASLECALLEKPMCIIYKSSFLTYVAA
EEEEECCCEEEEEECCCCEECCCCCCEEEEECCCCCEEEEECCCCEEEEEHHHHHHHHHH
MYFIKVKFLGLCNLLANKMMVPEFLQYDCNAIELSRYISNFHNDPNQAKSMINQLAKLKE
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLSSSQADCSLFDLVVAELPEKNA
HHCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA