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The map label for this gene is holA

Identifier: 52841576

GI number: 52841576

Start: 1484026

End: 1485051

Strand: Reverse

Name: holA

Synonym: lpg1346

Alternate gene names: 52841576

Gene position: 1485051-1484026 (Counterclockwise)

Preceding gene: 52841577

Following gene: 52841575

Centisome position: 43.71

GC content: 32.36

Gene sequence:

>1026_bases
ATGCAAATAAATCAACAAGCTCTTACTCAGCTTTTACAAAAAAAAATACATCATCTTAATGTACTAATTGGACAAGATCA
TTATCTTATTGACGAAGCACTCAATAACATAAAATCAATGCTTAAAAAATCATCTGAATGTGATGAGAAAATCCTCTCTA
TTCAGTCCCCTGAAGAATGGCATGTCGTTCTGGAAGAAACAAATAATTACTCTCTTTTTTATCAAACAGTTATTTTAACC
ATTTTCTTTGATAAAAAAACGATAGATACAACGGGAAAAAAAATTCTTAGTGAATATCTCAAATCAGCCAACTCTCATAG
TTATATTATTATCAGAGCCCCTAACCTTACCGCCAAGCAACTTCAATGGTTAACACATGATGAACAAGCGCTGATTATCA
TTGCACAACCATTAAGCTCAGAAGCAATGAAGAGATGGATTAATGAGCAATTAAAATTAAATACTATCTCTTTTGATCCA
TATGTTCCTGAATTAATTTATCAATATACTAAAGGAAATATGCTAGCTACCGCTCAGGTAATTGAAAAAATTACTTTGAG
CAATACACCCGGCACTCTCATTACTCCTTACCTGGCCTTGGAACATTTATCGGATCAATGTGATTTTTCCCTTTTTGAAC
TGATTGATTCATGCCTACTTGGTCATAGCGACAGAGCAATTCATATTTTAAGACAAGCTGCCAATAATAAAACAGAAGTC
ACATTGGTATTATGGATGCTTACCCAAGAAATAAGAACGCTATTACAATTATTATTTCTAATGCAACAAAAGATGGATAT
CAAAATGGCATCTAATCAATTAAAAATTTGGACTCAAAGAGTTAATCTTTATCAATCCGCTATTAAAAGATTAAACCCTT
TACTTTTACAACAACTTCATCACTATTGCCAATCTATTGATGATAAAATCAAATCCAACTCAAACAATCAAGTATGGAAT
GCTCTGGAGAACATTTCTCTTTCCTTATGTTTAGGGCAATTACTAGGTGATGCATGCATAGCATAG

Upstream 100 bases:

>100_bases
GACAGGATATTAGGGTCAAATGAAGAACAAGCTCTTTTAGTCAGCGAAATGAGGCGTGATGCCGCTATTCAAATCATTAA
TCGTTTAAACCGACCATGAT

Downstream 100 bases:

>100_bases
CAATATTTGGTGGAACATTTGACCCAGTGCATAATGGTCATATCAAGACCAGCTTGGCAATTCAAGCTAACTTTGGCTTT
GATTCCTATTATTTTTTACC

Product: DNA polymerase III, delta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQINQQALTQLLQKKIHHLNVLIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEWHVVLEETNNYSLFYQTVILT
IFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQLQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDP
YVPELIYQYTKGNMLATAQVIEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
TLVLWMLTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAIKRLNPLLLQQLHHYCQSIDDKIKSNSNNQVWN
ALENISLSLCLGQLLGDACIA

Sequences:

>Translated_341_residues
MQINQQALTQLLQKKIHHLNVLIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEWHVVLEETNNYSLFYQTVILT
IFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQLQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDP
YVPELIYQYTKGNMLATAQVIEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
TLVLWMLTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAIKRLNPLLLQQLHHYCQSIDDKIKSNSNNQVWN
ALENISLSLCLGQLLGDACIA
>Mature_341_residues
MQINQQALTQLLQKKIHHLNVLIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEWHVVLEETNNYSLFYQTVILT
IFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQLQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDP
YVPELIYQYTKGNMLATAQVIEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
TLVLWMLTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAIKRLNPLLLQQLHHYCQSIDDKIKSNSNNQVWN
ALENISLSLCLGQLLGDACIA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=284, Percent_Identity=23.943661971831, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39232; Mature: 39232

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINQQALTQLLQKKIHHLNVLIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEW
CCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHH
HVVLEETNNYSLFYQTVILTIFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQ
EEEEEECCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDPYVPELIYQYTKGNMLATAQV
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEHHHHH
IEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
HHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
TLVLWMLTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAIKRLNPLLLQQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHH
HYCQSIDDKIKSNSNNQVWNALENISLSLCLGQLLGDACIA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQINQQALTQLLQKKIHHLNVLIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEW
CCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHH
HVVLEETNNYSLFYQTVILTIFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQ
EEEEEECCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDPYVPELIYQYTKGNMLATAQV
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEHHHHH
IEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
HHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
TLVLWMLTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAIKRLNPLLLQQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHH
HYCQSIDDKIKSNSNNQVWNALENISLSLCLGQLLGDACIA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]