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The map label for this gene is htrA

Identifier: 52841561

GI number: 52841561

Start: 1468603

End: 1470003

Strand: Reverse

Name: htrA

Synonym: lpg1331

Alternate gene names: 52841561

Gene position: 1470003-1468603 (Counterclockwise)

Preceding gene: 52841562

Following gene: 52841560

Centisome position: 43.26

GC content: 39.54

Gene sequence:

>1401_bases
ATGAGTAAAATCAGGATTAATAATATGATTACACGTATAAAATTATTCATAGCAAGTCTGCTTGTATTTTTCATCCCGGT
AGCCGATGCAGCACAAGATCTTACAAACATGCCCAGCTTGGCTCCTGTTCTGAAAAATGCTATGCCGGCTATTGTTAACG
TGGCTGTTCAAGGGTACTTGCCTAATAATATGGCATCCGGAAATGCAGACGATGATGACGGGGAAAACAGTAAACAGCCT
TCCAGAATACCTGAAAAAGGCAGAAAATTTGAAAGTATAGGGTCTGGAGTTATCATTGACCCTAAAAATGGCATTATTAT
AACGAATGACCATGTTATTCGTAACGCCAATTTAATTACTGTAACTCTTCAAGATGGCAGGAGATTAAAAGCTCGCCTGA
TTGGAGGTGATAGCGAAACGGACTTGGCTGTTTTAAAAATTGATGCTAAAAATTTGAAATCCCTGGTAATTGGTGATTCC
GATAAGCTGGAAGTCGGAGATTATGTTGTTGCTATTGGAAACCCCTTTGGATTAAACAGCTTTGGAAATAGTCAATCTGC
TACGTTTGGAATAGTGAGTGCCTTAAAACGCAGCGATTTAAATATTGAAGGTGTTGAAAACTTTATTCAAACTGACGCAG
CTATCAATCCTGGTAATTCAGGAGGGGCTTTGGTCAATGCAAAAGGCGAATTAATTGGCATTAATACAGCCATTATTTCA
CCCTATGGAGGAAATGTAGGTATCGGCTTTGCGATCCCAATTAATATGGCAAAAGATGTAGCGCAACAAATCATTAAATT
TGGCTCTATTCATCGTGGTTTAATGGGTATATTTGTTCAACATTTAACACCAGAACTTGCCCAATCAATGGGATATGCCG
AAGATTTTCAAGGGGCTTTAGTATCACAGGTCAATCAAAATTCACCTGCTCAATTGGCTGGCCTAAAATCAGGCGATGTC
ATTGTACAAATTAATGACACCAAAATAACGCAGGCAACACAGGTAAAAACAACGATTAGTCTGTTGCGAGCTGGCTCTAC
TGCTAAAATTAAAATCTTGCGAGATAATAAGCCGCTTACATTAGATGTAGAAGTCACAGACATCAAAAAACATGAACAAA
AATTACAATCCAATAATCCATTTCTCTACGGATTAGCCTTGCGTAATTTTGAACAAGAGTCACCACCTCATGGTAATGTT
GTTGGAGTTCAGGTAGTAGGTGCTTCGGAAACCAGTGCGGGCTGGCGAGCTGGCTTAAGGCCAGGAGATATTATCATTTC
TGCTAATAAAACACCGGTCAAAGACATTAAATCTTTACAAGCTGTTGCACACGAGAAAGGGAAACAGCTATTAGTCCAGG
TGCTGAGAGGAGCAGGAGCACTCTACCTGTTGATCATTTAA

Upstream 100 bases:

>100_bases
GTATTTCAGTCAAATTTGTGTACTTTTGAGTTAAAAAATGAATTCTATTCCTATCGCAGAGAATCACAAACAGGTAGAAT
AGGTACTTTCATCTGGATTA

Downstream 100 bases:

>100_bases
ATTTTTTATCCAAATAATGAAATAACGCATCTTCTTTCTTTAAGCCCATCTCTGAGAGATGGGCTTAAATTTTGATAAAT
TATCCTGCTTTTGATAATGC

Product: protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSKIRINNMITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGNADDDDGENSKQP
SRIPEKGRKFESIGSGVIIDPKNGIIITNDHVIRNANLITVTLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDS
DKLEVGDYVVAIGNPFGLNSFGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIIS
PYGGNVGIGFAIPINMAKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNQNSPAQLAGLKSGDV
IVQINDTKITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNV
VGVQVVGASETSAGWRAGLRPGDIIISANKTPVKDIKSLQAVAHEKGKQLLVQVLRGAGALYLLII

Sequences:

>Translated_466_residues
MSKIRINNMITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGNADDDDGENSKQP
SRIPEKGRKFESIGSGVIIDPKNGIIITNDHVIRNANLITVTLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDS
DKLEVGDYVVAIGNPFGLNSFGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIIS
PYGGNVGIGFAIPINMAKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNQNSPAQLAGLKSGDV
IVQINDTKITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNV
VGVQVVGASETSAGWRAGLRPGDIIISANKTPVKDIKSLQAVAHEKGKQLLVQVLRGAGALYLLII
>Mature_465_residues
SKIRINNMITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGNADDDDGENSKQPS
RIPEKGRKFESIGSGVIIDPKNGIIITNDHVIRNANLITVTLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDSD
KLEVGDYVVAIGNPFGLNSFGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIISP
YGGNVGIGFAIPINMAKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNQNSPAQLAGLKSGDVI
VQINDTKITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNVV
GVQVVGASETSAGWRAGLRPGDIIISANKTPVKDIKSLQAVAHEKGKQLLVQVLRGAGALYLLII

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=285, Percent_Identity=34.7368421052632, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI24308541, Length=256, Percent_Identity=37.5, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI22129776, Length=279, Percent_Identity=34.7670250896057, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI7019477, Length=304, Percent_Identity=35.1973684210526, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1786356, Length=451, Percent_Identity=41.019955654102, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1789629, Length=448, Percent_Identity=40.625, Blast_Score=305, Evalue=5e-84,
Organism=Escherichia coli, GI1789630, Length=283, Percent_Identity=42.4028268551237, Blast_Score=193, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24646839, Length=294, Percent_Identity=35.7142857142857, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49613; Mature: 49482

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIRINNMITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYL
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCC
PNNMASGNADDDDGENSKQPSRIPEKGRKFESIGSGVIIDPKNGIIITNDHVIRNANLIT
CCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHCCCCEEECCCCCEEEECCEEEECCCEEE
VTLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDSDKLEVGDYVVAIGNPFGLNS
EEECCCCEEEEEEECCCCCCCEEEEEECHHCCCEEEECCCCCEEECCEEEEECCCCCCCC
FGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIIS
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEC
PYGGNVGIGFAIPINMAKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGAL
CCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHH
VSQVNQNSPAQLAGLKSGDVIVQINDTKITQATQVKTTISLLRAGSTAKIKILRDNKPLT
HHHHCCCCCCCEECCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEE
LDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNVVGVQVVGASETSAGWRAGLR
EEEEEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
PGDIIISANKTPVKDIKSLQAVAHEKGKQLLVQVLRGAGALYLLII
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
>Mature Secondary Structure 
SKIRINNMITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCC
PNNMASGNADDDDGENSKQPSRIPEKGRKFESIGSGVIIDPKNGIIITNDHVIRNANLIT
CCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHCCCCEEECCCCCEEEECCEEEECCCEEE
VTLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDSDKLEVGDYVVAIGNPFGLNS
EEECCCCEEEEEEECCCCCCCEEEEEECHHCCCEEEECCCCCEEECCEEEEECCCCCCCC
FGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIIS
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEC
PYGGNVGIGFAIPINMAKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGAL
CCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHH
VSQVNQNSPAQLAGLKSGDVIVQINDTKITQATQVKTTISLLRAGSTAKIKILRDNKPLT
HHHHCCCCCCCEECCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEE
LDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNVVGVQVVGASETSAGWRAGLR
EEEEEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
PGDIIISANKTPVKDIKSLQAVAHEKGKQLLVQVLRGAGALYLLII
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]