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The map label for this gene is trpF

Identifier: 52841534

GI number: 52841534

Start: 1431975

End: 1432598

Strand: Direct

Name: trpF

Synonym: lpg1303

Alternate gene names: 52841534

Gene position: 1431975-1432598 (Clockwise)

Preceding gene: 52841533

Following gene: 52841535

Centisome position: 42.14

GC content: 37.02

Gene sequence:

>624_bases
TTGAATCCATCTCGTATAAGAATCAAAATGTGCGGAATGACACGTTCAGAAGATATTCAATACGCCATTGATTTAGGGGT
GGACGCCATTGGCTTAATATTTTATCCCAAAAGTGTGCGTAATGTCTCACTGGAAAAAGCCAGAATAATAGTCAATAATA
TACCTCCATTTGTTGATATTGTTGCAGTTTTGGTAAACCCAGAACAATCTTTTGTTCAACTGATTATTAATGAAATTCCT
GTGCAGTTATTGCAATTTCATGGTGAGGAATCTTCAGAGTTTTGCAGACAATTTAATAAGCCGTTTATCAAAGCAATTCA
TCCTAAGACAGCAATCCAAATCCAAAGTGCTGTTGATGAGTTTTTTGATGCGAGCGCTATATTGTTGGATACACCATCAG
ACAAGGAACGAGGAGGAACGGGATTAACTTTTGACTGGAATATAATTCCTGAAAATTTATCCAAGCCTTACATATTGGCA
GGTGGTTTGAATGAATCTAACATTTTAGAGGCAATTACCATGTGTCATCCTTATGCAGTGGATGTGTGCAGTGGTATAGA
AGCTTCACCCGGAGTAAAAGATCATTTAAAAATGAGCCGATTTATAAAGGCAATATGGGGATAG

Upstream 100 bases:

>100_bases
TGCACCGTCATATGGCCTATATTTAGTCCAGGTGACTTATCCCAAAGAATTTGGATTGTTGCAAAATAATCCTGGCCCTT
TGTTTCTTTGGGAGAAATAA

Downstream 100 bases:

>100_bases
TATGATTAAAAAAGAGCTTCCAGATGAGTTTGGCCATTTTGGCCCATATGGCGGTATGTTTGTAGCCGATACATTAGTTC
ATGCTTTAAAACAATTAGAG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSVRNVSLEKARIIVNNIPPFVDIVAVLVNPEQSFVQLIINEIP
VQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDEFFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILA
GGLNESNILEAITMCHPYAVDVCSGIEASPGVKDHLKMSRFIKAIWG

Sequences:

>Translated_207_residues
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSVRNVSLEKARIIVNNIPPFVDIVAVLVNPEQSFVQLIINEIP
VQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDEFFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILA
GGLNESNILEAITMCHPYAVDVCSGIEASPGVKDHLKMSRFIKAIWG
>Mature_207_residues
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSVRNVSLEKARIIVNNIPPFVDIVAVLVNPEQSFVQLIINEIP
VQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDEFFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILA
GGLNESNILEAITMCHPYAVDVCSGIEASPGVKDHLKMSRFIKAIWG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=189, Percent_Identity=30.1587301587302, Blast_Score=74, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320210, Length=216, Percent_Identity=31.0185185185185, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 23046; Mature: 23046

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSVRNVSLEKARIIVNNIPPFVDI
CCCCEEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHEEEECCCCCHHHH
VAVLVNPEQSFVQLIINEIPVQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDE
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHH
FFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILAGGLNESNILEAITMCHPYAV
HHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCHHH
DVCSGIEASPGVKDHLKMSRFIKAIWG
HHHCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSVRNVSLEKARIIVNNIPPFVDI
CCCCEEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHEEEECCCCCHHHH
VAVLVNPEQSFVQLIINEIPVQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDE
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHH
FFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILAGGLNESNILEAITMCHPYAV
HHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCHHH
DVCSGIEASPGVKDHLKMSRFIKAIWG
HHHCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA