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The map label for this gene is hisC

Identifier: 52841431

GI number: 52841431

Start: 1325916

End: 1327010

Strand: Reverse

Name: hisC

Synonym: lpg1198

Alternate gene names: 52841431

Gene position: 1327010-1325916 (Counterclockwise)

Preceding gene: 52841432

Following gene: 52841430

Centisome position: 39.06

GC content: 37.9

Gene sequence:

>1095_bases
ATGTCCATACTCAATCTTGTTCGTGCAGATCTATTAAATAGTAAAAATTATGTCCCCGGTGGTGAGAGTGCTCGCTATCG
ATCACATGCCAATGAACTGCCTTGGTCACCAGTTACTATGGGGGAGCACAATTTAAATTATTACCCAAACATTGGCTTAC
AAATAGAGCTGCAAAAGCAATTGGCAAAACGTTATCAAATCTATTCCGATCAAATCATACTGACCAGAGGAAGTGATGAT
GGCATTGATTTGACAACCAGACTTTTTCTAACCGCCGGAAAAGACGCTTTCATGCAATTTCCCCCTACTTTTCCTATGTA
CGCTTTTTATGTTCGGCTACAACAAGCAGAATTGATCGAATGTCCTTTGGATAGAAGGACTAATTTTCGCCTCACCCTGG
ATCAAATTGAAAATAGCTGGAAACCAAACTGCAAAATTATCATGTTTTGTAGTCCCAATAACCCGACTGGTAATTTGGTG
GATTTAAATTTAATTGCCAAGACATGTGAACTGTATGCGAATCAATCTATTATAGTTGTGGACGAGGCGTATATAGAGTT
TGCAAATGCACCAAGCGCTACGTCCTTAATTGGAGAGTTTGAAAATCTGATTGTCTTAAGAACCCTGTCGAAAGCCTTTG
GGCTGGCTGGATTACGTTTAGGCTGCATTATAGCCCAGAGTCCTATTATTCAAGCTTTTAATAAAATCATTGCCCCCTAT
TCCATTGCCACTCCTAGTATGGAGCTGGCTAAAAGAGCTTTGAATAATAGCGATTGGTTCACAAAAACTATTGAGCAAAT
CAAATCATCTCGTGCCTGGGTTATAAAAAAATTTGCCGATAATCCAATCATTGAAAAAATTTATCCTACTGAAACCAATT
TCATTCTCATTCAAACACGATTTTCAAAACAATTAACCACTTGGCTTGCCCATTATGGCATCGCAGTAAGAGATTTTCCT
TCGTCCTCTTTATTGCATGATCACCTTCGTATTACGGTGGGTCATGATGAGCAAAATCAATTATTGATTAATACCTTATC
CTCATTTAACGCTGATGTAGCAGGATTAAATTATGAAAAAGATTTTATTTATTGA

Upstream 100 bases:

>100_bases
CCGTAATTTAGGTCCAGCGGCAATGACTTTAGCGGAATTAGAGGGTTTGGATGCTCATGCCAATGCCGTTCAAATAAGAC
TCAATACTCTGGGGGATTAA

Downstream 100 bases:

>100_bases
CCGCGATGGCACCTTAGTTGAAGAACCCTTTGATTTTCAAGTAGATTCTCTGGATAAAATTAAATTAACTTCTGGAGTAA
TACCAGCCCTATTGCAATTA

Product: histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase)

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSILNLVRADLLNSKNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQLAKRYQIYSDQIILTRGSDD
GIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKIIMFCSPNNPTGNLV
DLNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLTTWLAHYGIAVRDFP
SSSLLHDHLRITVGHDEQNQLLINTLSSFNADVAGLNYEKDFIY

Sequences:

>Translated_364_residues
MSILNLVRADLLNSKNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQLAKRYQIYSDQIILTRGSDD
GIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKIIMFCSPNNPTGNLV
DLNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLTTWLAHYGIAVRDFP
SSSLLHDHLRITVGHDEQNQLLINTLSSFNADVAGLNYEKDFIY
>Mature_363_residues
SILNLVRADLLNSKNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQLAKRYQIYSDQIILTRGSDDG
IDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKIIMFCSPNNPTGNLVD
LNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPYS
IATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLTTWLAHYGIAVRDFPS
SSLLHDHLRITVGHDEQNQLLINTLSSFNADVAGLNYEKDFIY

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=359, Percent_Identity=33.7047353760446, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1788722, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=334, Percent_Identity=29.940119760479, Blast_Score=139, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41330; Mature: 41199

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILNLVRADLLNSKNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQ
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEHHHH
LAKRYQIYSDQIILTRGSDDGIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIE
HHHHHHHCCCEEEEECCCCCCCCEEEEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHC
CPLDRRTNFRLTLDQIENSWKPNCKIIMFCSPNNPTGNLVDLNLIAKTCELYANQSIIVV
CCCCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEE
DEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
EHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHCCC
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTR
CCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEEEEC
FSKQLTTWLAHYGIAVRDFPSSSLLHDHLRITVGHDEQNQLLINTLSSFNADVAGLNYEK
HHHHHHHHHHHCCEEEEECCCCHHEEEEEEEEECCCCCCCCCEEEHHHCCCCCCCCCCCC
DFIY
CCCC
>Mature Secondary Structure 
SILNLVRADLLNSKNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQ
CHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEHHHH
LAKRYQIYSDQIILTRGSDDGIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIE
HHHHHHHCCCEEEEECCCCCCCCEEEEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHC
CPLDRRTNFRLTLDQIENSWKPNCKIIMFCSPNNPTGNLVDLNLIAKTCELYANQSIIVV
CCCCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEE
DEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
EHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHCCC
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTR
CCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEEEEC
FSKQLTTWLAHYGIAVRDFPSSSLLHDHLRITVGHDEQNQLLINTLSSFNADVAGLNYEK
HHHHHHHHHHHCCEEEEECCCCHHEEEEEEEEECCCCCCCCCEEEHHHCCCCCCCCCCCC
DFIY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA