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The map label for this gene is pdc [H]

Identifier: 52841389

GI number: 52841389

Start: 1273915

End: 1275594

Strand: Direct

Name: pdc [H]

Synonym: lpg1155

Alternate gene names: 52841389

Gene position: 1273915-1275594 (Clockwise)

Preceding gene: 52841388

Following gene: 52841391

Centisome position: 37.49

GC content: 39.94

Gene sequence:

>1680_bases
ATGTGCTCAATTGGAGAGTATTTGGCAAAGCGGCTGGAGGAATTAAATATTTCTGAATATTTTGCTATACCGGGTGATTA
CAATCTTATTTTACTCGATGAGGTCCTGAAAAACGAAAAAATAAAAATGATTAATTGCTGTAATGAGTTGAATGCCGGAT
ACGCTGCTGATGGCTATGCCCGTGTAAAAGGGGTTTCTGCTTTATTCGTTACTTATAGTGTCGGTGGACTTAGTGTTGTT
AATGCAGTTGCAGGAGCATATGCTGAAAATCTTCCCATTTTGGTTATATCAGGTGGCCCAAATACCAACTCCATACAGGA
TGCTGAAATTCTCCATCACACGTTGGCGACTGAAGATAATTTGTATGTAAGGGACATTTTTTCTCGAATTACTGCCCATG
TCGTTTGTATTCGAAAGCCAGAGCAGGCTGCCATGCAGATAGACGAGGCTATAGCAATCGCAATCGCTAAAAAAAAGCCG
GTCTATATTGAAATAGCGTGTAATATTGCTAACTATCCTATCTCCAAGCCTACTCAACGCGCATTCAACACCTATAAAAT
TAGCGACAGTTCGTCTCTGGCTGCAGCAGTAGAGCATGCTGCTGAAAAATTAAACTCCGCTCTAAAGCCCAGCTTGATTG
TAGGTAGTAAGGTTAGGCATTGTAATGCAATCAATTCTGTCAGCGAGTTGGCAAAGTGTACTGGATATGCTATGGCGGCT
ATGCCCGATGCGAAAGGATTTATCTCAGAACAGCATCCTAACTTTATAGGTATCTATTGGGGACCAGTCAGCTCTTCTGG
ATGCGCCGAAATTATCGATTCCAGTGATGCCTATCTGCTTATTGGGCCTAATGAGAATGACTATACTACAGTTGGGTATG
TATGGGGAATCAACCCCCACAAATCAATAAAGACCACCAAGGGAGGGGTTATTATTGGTGAAACAGTTTATACCAATATC
TTCATGAATGATTTTCTCAGAGAATTAAGTAAAAAATTAAAATTTAATGATGCTTCATACAAAGCTTATAAACGAATTGC
TGAAGAAACTGTTGTCTATCCAGAGTTAGATCAACCTGACGCTCCATTAAGCAGCCGTTATTTGTTTGGCCAAATTCAGA
AAATGCTTTCTGACAAAAAAGCTTTGTTGGCTGAAACAGGGGACTCCTGGTTTAATTGTATGCGCCTGTCTTTGCCTGAA
GGTTGTCCTTTCGAAATTCAAATGCAGTATGGTTCTATTGGTTGGTCAGTGGGTGCTTTGCTAGGCATGCAAGCTGCTTT
GCATAATCAAAAAAGAGTGATTGCCTGCATAGGAGATGGCTCATTTCAAATGACTGCCCAGGAAATATCAACCATGATAC
GTTACGGGTATAAACCAATTATTTTTTTAATGAATAATGCTTGTTACACTATTGAAGTACAAATTCATGATGGTCCTTAT
AATGTCATTAATAATTGGCGTTACGCTGAACTGGTTAATGTATTCCGCGGGGAACAGAGTAATGCAAAATCTTTTGTAGT
TAAAACCAACAAGGAACTACTCACTGCAATTAAACAGGCAGAAAAAACAGACGCGCTTTGTTTTATTGAGGTGTTCCTGG
ACAAGGATGATTGCAATAAAAACTTGTTGGAATGGGGCTCAAGAGTGGCAAATTATAATAGCCGTCCTCCTCGTAGATAG

Upstream 100 bases:

>100_bases
ATGCCTTGTGAACTCTATTTTTTAGCAGGTATTCACTTGCCACCTACTGATTTTTGGCTGTGCTATAATTTAAAAAGTTC
TTATTTAATAAGGGATTAAC

Downstream 100 bases:

>100_bases
ATCTTGGGTAGGAATTATAAGAATCGCCTACCCTGATATTAATGATTTGACGTGTTTTTATTTGGAGCCCAGCTCTATTG
AGAAAGCAATGGCCAGCTTT

Product: pyruvate decarboxylase

Products: NA

Alternate protein names: PDC [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKIKMINCCNELNAGYAADGYARVKGVSALFVTYSVGGLSVV
NAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDNLYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKP
VYIEIACNIANYPISKPTQRAFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPHKSIKTTKGGVIIGETVYTNI
FMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPDAPLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPE
GCPFEIQMQYGSIGWSVGALLGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNKNLLEWGSRVANYNSRPPRR

Sequences:

>Translated_559_residues
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKIKMINCCNELNAGYAADGYARVKGVSALFVTYSVGGLSVV
NAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDNLYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKP
VYIEIACNIANYPISKPTQRAFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPHKSIKTTKGGVIIGETVYTNI
FMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPDAPLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPE
GCPFEIQMQYGSIGWSVGALLGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNKNLLEWGSRVANYNSRPPRR
>Mature_559_residues
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKIKMINCCNELNAGYAADGYARVKGVSALFVTYSVGGLSVV
NAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDNLYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKP
VYIEIACNIANYPISKPTQRAFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPHKSIKTTKGGVIIGETVYTNI
FMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPDAPLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPE
GCPFEIQMQYGSIGWSVGALLGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNKNLLEWGSRVANYNSRPPRR

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=478, Percent_Identity=24.6861924686192, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323163, Length=562, Percent_Identity=31.4946619217082, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6323073, Length=562, Percent_Identity=30.7829181494662, Blast_Score=262, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6321524, Length=566, Percent_Identity=29.8586572438163, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320123, Length=558, Percent_Identity=27.7777777777778, Blast_Score=235, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320588, Length=602, Percent_Identity=25.0830564784053, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323755, Length=577, Percent_Identity=21.8370883882149, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.1 [H]

Molecular weight: Translated: 61872; Mature: 61872

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKIKMINCCNELNAGYAADGYA
CCCHHHHHHHHHHHCCCHHEEECCCCCCEEEEHHHHCCCCEEEHHHHHHCCCCCCCCCHH
RVKGVSALFVTYSVGGLSVVNAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDN
HHCCCEEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCC
LYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKPVYIEIACNIANYPISKPTQR
CHHHHHHHHHHHEEEEEECCHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCHHH
AFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEC
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPH
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCC
KSIKTTKGGVIIGETVYTNIFMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPD
CCCEECCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEECCCCCCCC
APLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPEGCPFEIQMQYGSIGWSVGAL
CCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHEEEECCCCCCCEEEEEECCCCCHHHHHH
LGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
HHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEEEEEECCCH
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNK
HHHCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCH
NLLEWGSRVANYNSRPPRR
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKIKMINCCNELNAGYAADGYA
CCCHHHHHHHHHHHCCCHHEEECCCCCCEEEEHHHHCCCCEEEHHHHHHCCCCCCCCCHH
RVKGVSALFVTYSVGGLSVVNAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDN
HHCCCEEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCC
LYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKPVYIEIACNIANYPISKPTQR
CHHHHHHHHHHHEEEEEECCHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCHHH
AFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEC
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPH
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCC
KSIKTTKGGVIIGETVYTNIFMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPD
CCCEECCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEECCCCCCCC
APLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPEGCPFEIQMQYGSIGWSVGAL
CCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHEEEECCCCCCCEEEEEECCCCCHHHHHH
LGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
HHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEEEEEECCCH
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNK
HHHCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCH
NLLEWGSRVANYNSRPPRR
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3546263; 3029726; 3029037; 2838467; 8645153; 9655927; 9685367 [H]