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The map label for this gene is capD [H]

Identifier: 52841201

GI number: 52841201

Start: 1058084

End: 1059961

Strand: Direct

Name: capD [H]

Synonym: lpg0966

Alternate gene names: 52841201

Gene position: 1058084-1059961 (Clockwise)

Preceding gene: 52841200

Following gene: 52841204

Centisome position: 31.14

GC content: 41.91

Gene sequence:

>1878_bases
GTGGTTTTTATAATGCAAAAAATAATCATATTGACAAAAAAAATCATTGCAAAACTCCCAGTAATTTTGTTTGATGTGGC
TGCAATACCAGTTGCCTGGTATGCCGCTTACTGGTTGCGCTATAACATGCAGCCATATCCCAGCAGCCTGACATCCACCC
ATTCTTTTATTGCTTTAGCTTTATTATCAATTGTTCAGATTAGTTGTTACTATTATTTTAAAATTTACAGAGGATTATGG
CGTTTCTCTTCTCTGAATGATGTCATCAGGATACTGAAGGCTACTATCACAGCAATGGTTTTAGTAATCCCTGTTTTTTA
CTTGACTTCAATTCTTCAGCACCTGCCCAGATCAGTTTTTCCTTTGTATTGCATTATCCTGGCTACCATCCTTTGCGGGG
GAAGGTTGGTAATCCGTCTGCATTGGGATAAGCCTGGCAGAGGAAACAGGGAATTGGAAACGAAAAGAGTTTTGGTGGTT
GGTGCCGGGCAGGCTGGTGAAGGCTTGGTGCGTGATTTGAAAAGAAGCAGTTATTATCGGCCAATAGGCTTTGTAGATGA
CAATAAAAGCAAGAGAGGATTAGAAGTTCATGGAGTGCGGGTTCTGGGAACGACCAACCAAATTACCGAATTAGTCAATC
AGTACGACGTGGATTTGATTTTCATTGCCATACCTTCTGCCAAATCGGCAACCATGCGAAGAATTGTAACGCTTTGTGAA
CAAAGCCATGTGCCTTTTAGTACTTTACCCAGTATTTCAGCCCTGGCTGCGGGTCGAGTTGAAGTGAATGCGCTGAGGCC
TGTGAATATTGAGGATTTATTGGGTCGGGATCAAGTGACGCTCGAATGGGAAAAAATTGCTCGTTCAATCGCAGGAAGAC
GCATATTGATTACAGGCGGTGGTGGCTCAATCGGTTCGGAATTGTGCCGTCAGGTTATGGCTTTAGAGCCTGCGAGCATA
GCTATTGTTGAGAATAGTGAATTTAACCTGTATCGCATTGAACAGGAGTTGTTAAAGAGTTTTCCAGGTATTCCCGTTGA
ATTGAGTTTAATCAGTGTGACAGACGAAATTGCGATTAATCACTTATTTCGTCGGTTTCAACCTGAAATTGTATTTCATG
CGGCTGCATACAAACATGTTCCCATGCTTCAGCATCAAGTACGAGTTGCTGTGTTTAATAATGTCATAGGTACTCAGGTT
GTTGCCAAAGCCAGTGTGACATTCGGAGCTGAGAAGTTCATTTTAATTTCCACTGATAAAGCAGTGAATCCAACGAATAT
AATGGGAACTACCAAGAGAGTCGCTGAAATTTATTGTCAGAATTTAAATACACGAGTTAAAACCCAGTTTATTACGGTTC
GTTTTGGAAATGTCTTGGGTTCAGCTGGTAGTGTGGTGCCTTTGTTCCAAAAACAGTTGCAGGAGGGGGGGCCACTGACT
GTGACCCATCCCGATATGCAAAGATATTTTATGACTATACCGGAAGCATGCCAATTGATTTTGCAAGCGATGGTGAATGG
GGAGGGCGGTGAAATTTTTGTCCTGGATATGGGAGAGCCGGTTAAAATCAGTTATCTTGCAGAGCAAATGATTCGCTTGG
CAGGCAAAGAACCGGGAAGAGACATCATGATTGAATATACAGGGTTGCGTCCTGGCGAGAAAATGTATGAAGAGTTGTTT
CATGAGACTGAACAGTTAACTTCAACAAAACATGAAAAACTATTCAAAGCAAGGTTTCGTGAACTGGATTGGAATGATTT
GACACAAACCATGCGAATGTTGCAGGCAGCTTGTATTGAGCATCAGGATGAAGAATTGCTTGTTCTGTTAAAAAGTCTGG
TGCCTGAGTTTCAATTGGAACCTATGGTTGAAGCTTAA

Upstream 100 bases:

>100_bases
CAGTGCTGAGTCACAATATAGGTATGAATTGTTTGCTAATTTTTGATGCGGGAAACTGTAACATAGTGTACCATCTTTCC
TTTATAAAGGATTACAGACT

Downstream 100 bases:

>100_bases
GCAATAGACCTAATCTGGTAAATCAAGATTGTGTTATGTCAATTACTTATGTTGATTTTGAAACGCTATTTTCTCATAAT
TTGATGGTAAAATGAAAAAC

Product: nucleoside-diphosphate sugar epimerases

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALALLSIVQISCYYYFKIYRGLW
RFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVV
GAGQAGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASI
AIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQV
VAKASVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELF
HETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA

Sequences:

>Translated_625_residues
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALALLSIVQISCYYYFKIYRGLW
RFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVV
GAGQAGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASI
AIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQV
VAKASVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELF
HETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA
>Mature_625_residues
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALALLSIVQISCYYYFKIYRGLW
RFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVV
GAGQAGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASI
AIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQV
VAKASVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELF
HETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=290, Percent_Identity=25.1724137931034, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 70372; Mature: 70372

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALA
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLSIVQISCYYYFKIYRGLWRFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
PLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVVGAGQAGEGLVRDLKRSSYYR
HHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCC
PIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
CCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGG
CCCCCHHHCCCHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHCCCEEEEECC
GGSIGSELCRQVMALEPASIAIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAIN
CCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCCCCEEEEEEEHHHHHHHH
HLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKASVTFGAEKFILISTDK
HHHHHCCCHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCC
AVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECHHHCCCCCCHHHHHHHHHCCCCEE
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGR
EECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
DIMIEYTGLRPGEKMYEELFHETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIE
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
HQDEELLVLLKSLVPEFQLEPMVEA
CCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALA
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLSIVQISCYYYFKIYRGLWRFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
PLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVVGAGQAGEGLVRDLKRSSYYR
HHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCC
PIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
CCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGG
CCCCCHHHCCCHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHCCCEEEEECC
GGSIGSELCRQVMALEPASIAIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAIN
CCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCCCCEEEEEEEHHHHHHHH
HLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKASVTFGAEKFILISTDK
HHHHHCCCHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCC
AVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECHHHCCCCCCHHHHHHHHHCCCCEE
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGR
EECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
DIMIEYTGLRPGEKMYEELFHETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIE
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
HQDEELLVLLKSLVPEFQLEPMVEA
CCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]