Click here to switch to the map view.

The map label for this gene is mraW

Identifier: 52841149

GI number: 52841149

Start: 986616

End: 987620

Strand: Direct

Name: mraW

Synonym: lpg0914

Alternate gene names: 52841149

Gene position: 986616-987620 (Clockwise)

Preceding gene: 52841148

Following gene: 52841150

Centisome position: 29.04

GC content: 40.9

Gene sequence:

>1005_bases
ATGGCTGGCAGAAGAAGCGTCCATGACGGATGGGTTACCCGAGGAAATGAAAACGTTTTCTTTATAACGGAAAGAGAAAT
GGCAAAGCATCAATCTGTTTTATTACATGAATCAATCAAAGGTTTGGCTATAAAAGCTGACGGTATCTATTTTGATGGAA
CTTTTGGCCGAGGAGGCCACAGCCGCGAGATTTTAAATCATTTAAGCGATAAAGGAAGATTGTTTGCAATAGATAAGGAC
CTTGATGCGGTGCAATATGCCAAGGATTATTTTGGTTTGGATAAACGATTTCAAATTTTTCACGGTTCATTCGCGCAAAT
CAAGGAATTTGCGTCACAAGCGGGGGTAATTGGGGCCGTTGATGGAATTTTGCTTGATCTGGGAGTGTCTTCACCTCAGT
TGGACAATCCAGAAAGAGGTTTTAGTTTTATGCTGCAAGGCCCTCTCGATATGCGAATGGATTTAACTCAATCAATTAAT
GCTGCGAATTTTGTTAATGAAGCAGAGGTCAACGAGCTGGCTCATGTATTCAGGGCTTATGGTGAGGAACGATTTGCAGG
CAGGATTGCAAAAGCTATTGTTGATGCAAGAAAACTAAAACCAATAACAACCACTTTGGAGTTAGCGGAAATTGTTAAAG
AAGCAAACCCCAAATGGGAAAAACACAAACATCCTGCAACCCGGGTATTTCAAGCGATTCGAATACATGTCAATCAGGAA
TTAACCGATTTGAGTAATTGTCTAGAGCAATGTCTGGACGTGTTGGGGCCAGGAGGACGCTTGGCCGTTATCAGTTTCCA
CTCTTTGGAAGACCGAATAGTCAAACAATTTATGAGAGATAAAGAGCAAGGTAACAGGCCACCTGTTGAAGTTCCAATCA
AATACGAAGAACTAAAGACCAATTTTAAAAAAGTAGGTAAAGCAGTGAAACCACAGAGTAGCGAAATAAAGGAAAATGTT
AGATCTCGAAGTGCAGTACTTAGGATAGGGGAGAAATTAGCATGA

Upstream 100 bases:

>100_bases
TAAGAAATTATGCAAAGCTGGAAAAAGATGTCGTGATGATAGGCCAGGGAAATAAATTTGAGGTTTGGAATAAAGAATTA
TGGGAATCCAAGCGTGAGCA

Downstream 100 bases:

>100_bases
ACGCTGCAGCGAAAGTCATTAATCAAGGTAATTTATTTAATGGTCAATTGGCAGATATGCAAATGTCAAAATCACTCTAT
ATGTTGATAGTATTGTTAGC

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAGRRSVHDGWVTRGNENVFFITEREMAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKD
LDAVQYAKDYFGLDKRFQIFHGSFAQIKEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSIN
AANFVNEAEVNELAHVFRAYGEERFAGRIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQE
LTDLSNCLEQCLDVLGPGGRLAVISFHSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKKVGKAVKPQSSEIKENV
RSRSAVLRIGEKLA

Sequences:

>Translated_334_residues
MAGRRSVHDGWVTRGNENVFFITEREMAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKD
LDAVQYAKDYFGLDKRFQIFHGSFAQIKEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSIN
AANFVNEAEVNELAHVFRAYGEERFAGRIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQE
LTDLSNCLEQCLDVLGPGGRLAVISFHSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKKVGKAVKPQSSEIKENV
RSRSAVLRIGEKLA
>Mature_333_residues
AGRRSVHDGWVTRGNENVFFITEREMAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKDL
DAVQYAKDYFGLDKRFQIFHGSFAQIKEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSINA
ANFVNEAEVNELAHVFRAYGEERFAGRIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQEL
TDLSNCLEQCLDVLGPGGRLAVISFHSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKKVGKAVKPQSSEIKENVR
SRSAVLRIGEKLA

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=343, Percent_Identity=39.9416909620991, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI165377202, Length=199, Percent_Identity=43.7185929648241, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786270, Length=311, Percent_Identity=54.0192926045016, Blast_Score=332, Evalue=2e-92,
Organism=Drosophila melanogaster, GI62472493, Length=349, Percent_Identity=34.9570200573066, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI28571637, Length=349, Percent_Identity=34.9570200573066, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 37507; Mature: 37376

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRRSVHDGWVTRGNENVFFITEREMAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGH
CCCCCCCCCCCEECCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCCCC
SREILNHLSDKGRLFAIDKDLDAVQYAKDYFGLDKRFQIFHGSFAQIKEFASQAGVIGAV
HHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCHHHH
DGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSINAANFVNEAEVNELAHVFRAY
HHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GEERFAGRIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQE
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCHH
LTDLSNCLEQCLDVLGPGGRLAVISFHSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKT
HHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHH
NFKKVGKAVKPQSSEIKENVRSRSAVLRIGEKLA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGRRSVHDGWVTRGNENVFFITEREMAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGH
CCCCCCCCCCEECCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCCCC
SREILNHLSDKGRLFAIDKDLDAVQYAKDYFGLDKRFQIFHGSFAQIKEFASQAGVIGAV
HHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCHHHH
DGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSINAANFVNEAEVNELAHVFRAY
HHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GEERFAGRIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQE
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCHH
LTDLSNCLEQCLDVLGPGGRLAVISFHSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKT
HHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHH
NFKKVGKAVKPQSSEIKENVRSRSAVLRIGEKLA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA