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The map label for this gene is metC

Identifier: 52841125

GI number: 52841125

Start: 962856

End: 964007

Strand: Reverse

Name: metC

Synonym: lpg0890

Alternate gene names: 52841125

Gene position: 964007-962856 (Counterclockwise)

Preceding gene: 52841132

Following gene: 52841124

Centisome position: 28.37

GC content: 41.67

Gene sequence:

>1152_bases
ATGAATAAGACTCATTTCGATACACGTGCAATTCATGCTGGGCAAGAACCATGTAAAAGTACAGGGGCCGTGATGACCCC
TATTTATGCTACCTCCACCTATAAACAAATTGCTCCTGGCGAACATCTTGGCTATGAATACTCACGCACCCAGAACCCCA
CCAGAAAGGCCTATGAGGATTGCATAGCAAGTCTTGAATCAGGCCAAAAAGGATTTGCGTTTGCTTCAGGTATGGCTGCC
ATCAATACAGTTATTGATTTATTAGGTTCCGGAGATCACGTCGTTGCCATGGATGATCTTTATGGAGGGACTTTCCGGCT
TTTTGATAAAGTAAAAACCCGAACTTCTAATTTATCCTTTTCTTTTATTGATATGTCAGTACCCGAGAATATTGAAGCTG
CAATAACTCCGAAGACAAAATTACTATGGTTGGAAACCCCTTCCAATCCCATGCTAAAGCTAGCTAATTTACGAAAAATC
GCTGCTATTGCAAAAAAATATAATTTGATTACAGTTGCCGATAACACCTTTGCAACTCCCTGGATTCAACGCCCTCTTGA
ACTCGGATTTGACATTGTACTTCATTCAGCAACCAAATATCTGAACGGACATTCTGATGTAGTCAGTGGTGTCGTTGTGG
TCGGTGACAATTCAGTGTTGTCTGATAAAATTGCTTTTTTGCAAAATTCATGCGGCGCTGTAGCTGGCCCTTTCGACAGT
TTCCTGGTTCTGAGAAGCTTAAAAACATTATCCGTTCGTATGCAAAGGCACTGTGAAAACGCTAACCATCTGGCTAACTG
GCTTAGCAGCCACCCCAAGATTGAAAAAGTCATTTATCCCGGATTAAAAAGTCATCCGCAATATTCTCTTGCCAAGGAAC
AAATGAACAATTTCGGTGGTATGATATCTTTGGTACTTAAAGGTAGTCTTGAAGATGCCAAACGATTTTTAGCTCGCTGC
GAATTATTTACTTTGGCTGAAAGCCTGGGGGGTGTAGAAAGTTTAATTGAGCATCCTGCAATTATGACCCATGCCTCTAT
TCCAGTCGAACAACGCAAAGCCCTGGGCATAGAAGATGGTTTCATAAGATTATCAGTTGGTATTGAACACATTGATGATC
TGCGTGCCGATCTGGAGCATGCTTTAGGTTAA

Upstream 100 bases:

>100_bases
GAACTTTAGTAATAAAAGCGACGAAAGTATAATTTTTAATCAAATTTTTGATCGCTTATTGGTATTTCTTTGAATTTAAA
TATTTTTATGGGAATAAAAA

Downstream 100 bases:

>100_bases
AAGATGTAAATCCTGGTTCTGACTGTTAAAAAGAACCAGGGCAGATGTGTATAGGAGAAGTATTTCATGCAAAAAAATAA
ACAAAATGGCGGGCAACTCC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MNKTHFDTRAIHAGQEPCKSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLGSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKYNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNNFGGMISLVLKGSLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG

Sequences:

>Translated_383_residues
MNKTHFDTRAIHAGQEPCKSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLGSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKYNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNNFGGMISLVLKGSLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG
>Mature_383_residues
MNKTHFDTRAIHAGQEPCKSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLGSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKYNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNNFGGMISLVLKGSLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=52.6027397260274, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=47.6712328767123, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=47.5274725274725, Blast_Score=312, Evalue=4e-85,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=42.2872340425532, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1789383, Length=398, Percent_Identity=27.3869346733668, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17538055, Length=368, Percent_Identity=49.1847826086957, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17560056, Length=368, Percent_Identity=47.554347826087, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71980708, Length=391, Percent_Identity=37.3401534526854, Blast_Score=258, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=46.2337662337662, Blast_Score=336, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6321254, Length=404, Percent_Identity=33.9108910891089, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323333, Length=435, Percent_Identity=34.4827586206897, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321170, Length=327, Percent_Identity=28.4403669724771, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321904, Length=343, Percent_Identity=30.6122448979592, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322970, Length=351, Percent_Identity=25.0712250712251, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922554, Length=380, Percent_Identity=48.6842105263158, Blast_Score=380, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41976; Mature: 41976

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTHFDTRAIHAGQEPCKSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYED
CCCCCCCHHHHHCCCCHHHHCCCEECCEEECCCHHHCCCCCCCCCCHHCCCCHHHHHHHH
CIASLESGQKGFAFASGMAAINTVIDLLGSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEE
SFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKIAAIAKKYNLITVADNTFATP
EEEECCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCH
WIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
HHHHHHHCCHHHHHHHHHHHHCCCHHHHCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHH
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNNFGG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCH
MISLVLKGSLEDAKRFLARCELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCCHHHHHHCCCCCC
FIRLSVGIEHIDDLRADLEHALG
EEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKTHFDTRAIHAGQEPCKSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYED
CCCCCCCHHHHHCCCCHHHHCCCEECCEEECCCHHHCCCCCCCCCCHHCCCCHHHHHHHH
CIASLESGQKGFAFASGMAAINTVIDLLGSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEE
SFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKIAAIAKKYNLITVADNTFATP
EEEECCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCH
WIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
HHHHHHHCCHHHHHHHHHHHHCCCHHHHCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHH
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNNFGG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCH
MISLVLKGSLEDAKRFLARCELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCCHHHHHHCCCCCC
FIRLSVGIEHIDDLRADLEHALG
EEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]