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The map label for this gene is hapE [H]

Identifier: 52841067

GI number: 52841067

Start: 910755

End: 912098

Strand: Direct

Name: hapE [H]

Synonym: lpg0831

Alternate gene names: 52841067

Gene position: 910755-912098 (Clockwise)

Preceding gene: 52841066

Following gene: 52841077

Centisome position: 26.8

GC content: 39.88

Gene sequence:

>1344_bases
TTGATGGAAATAAAAAGGGTGCTTAAGGACCGTCTGTCTGCCCGTGTTTGTGTGATCGGTGCTGGTCCCAGCGGTATTGC
TGCCATTAAAAATTTGCAAGAACACGGCATTACTAATGTTACTGTCTTTGAAAAAAACAATCAAATAGGTGGTAATTGGG
TTTATGATGAGCAAAATGAGCATTCCAGCGTTTATGAGACGACTCATATCATTAGTTCAAAACGCTGGTCTGAGTTTGAA
GATTTCCCTATGCCTGTTGATTACCCGGATTATCCTTCACACTCCCAGCTTTTAAAATATTTTCAGAGTTATGTGGAGCA
TTTTCATTTAGATAGATACATTCGTTTTAACACAGTGGTACAAAAGGTACATCGACTTGATGATAATACATGGCATGTTA
TCTATGAGGATGCCCAAGGAATTCATGAAGCGTGCTATGACTATTTGCTGGTAGCTAATGGTCATCATTGGGATCCCTTT
ATGCCTGTATATCCTGGAGTATTTGACGGGGAGATACTTCATTCTCACCAATATAAAAAAGCTTCAATTTTTAAAGGCAA
GCGAGTACTGGTTGTTGGCGGGGGTAATTCAGCCTGTGATGTCGCTGTTGAAATATCGCGGGTTGCTCCCGGAACTTGCA
TTAGCATGCGTAGAGGGTATCATATTTTCCCCAAATTTATTTTTGGTAAGCCAACGGATGTAGCAGTAGCTAAAATACAA
TGGATGCCATCCTGGCTAAGGCAGAAGTTCATCAGTTTGGTTATTAGAGGCTTGCAAGGCCGGTATGCCAAGTATAAATT
AATGAAGCCCGATTGTGGGCCATTGGAAATTCACCCTACTATTAATTCCGAACTCTTGTATTTTATTCGCCATGGCAAAA
TACACCCCCGTTCGGGTATATCGAGATTTGAGGGCAACACAGTTCATTTTACTGATAGAACCCAAGGGGAGTTCGATACG
ATCATTTTCGCTACGGGTTACCAAATCAGTTTTCCATTTTTTGATAAAAGTTGTATTGATTTTAGTAACTCTACCACGAT
CCCTTTATATCGAAAAATGATGCACCCCGAGTTTGAAAATTTGTATTTCATTGGCCTATGCCAACCTCAAGGTTGCATTT
GGCCTTTGGCTGATTATCAATCAAAAATAGTAGCTCGCATTATTGCAGGGACTTTGAAACGACCTGATCAATTACATCGA
AAAATAGCCAAAGAAATCAATAAACCCCATCACCGATTTAAATCGCACATGCGCCATGCTCTAGAGGTCGATTATCATAT
TTTCAGAAAAGAATTGTTAGAAATGCTAGGCCAAAAACATAAGAGACTGAAATTCTATCCCTAG

Upstream 100 bases:

>100_bases
AATGTTGATTCGATAAAAGGGATAAAAGTAAATCATTTTACAATTGACAAAGACGAAATTTTACAAGCGATGATAATGGA
TAAAGTTGATAAGGTGTTAG

Downstream 100 bases:

>100_bases
ATTCGTTATGAGTACATGAATGTTAAAGCATGGATGCTCACATCAGTTATAAGCCGCCTTACACTTATTCTGTTTTGAAA
ATCACAAACAATTTACAGAT

Product: flavin containing monooxygenae

Products: NA

Alternate protein names: HAPMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MMEIKRVLKDRLSARVCVIGAGPSGIAAIKNLQEHGITNVTVFEKNNQIGGNWVYDEQNEHSSVYETTHIISSKRWSEFE
DFPMPVDYPDYPSHSQLLKYFQSYVEHFHLDRYIRFNTVVQKVHRLDDNTWHVIYEDAQGIHEACYDYLLVANGHHWDPF
MPVYPGVFDGEILHSHQYKKASIFKGKRVLVVGGGNSACDVAVEISRVAPGTCISMRRGYHIFPKFIFGKPTDVAVAKIQ
WMPSWLRQKFISLVIRGLQGRYAKYKLMKPDCGPLEIHPTINSELLYFIRHGKIHPRSGISRFEGNTVHFTDRTQGEFDT
IIFATGYQISFPFFDKSCIDFSNSTTIPLYRKMMHPEFENLYFIGLCQPQGCIWPLADYQSKIVARIIAGTLKRPDQLHR
KIAKEINKPHHRFKSHMRHALEVDYHIFRKELLEMLGQKHKRLKFYP

Sequences:

>Translated_447_residues
MMEIKRVLKDRLSARVCVIGAGPSGIAAIKNLQEHGITNVTVFEKNNQIGGNWVYDEQNEHSSVYETTHIISSKRWSEFE
DFPMPVDYPDYPSHSQLLKYFQSYVEHFHLDRYIRFNTVVQKVHRLDDNTWHVIYEDAQGIHEACYDYLLVANGHHWDPF
MPVYPGVFDGEILHSHQYKKASIFKGKRVLVVGGGNSACDVAVEISRVAPGTCISMRRGYHIFPKFIFGKPTDVAVAKIQ
WMPSWLRQKFISLVIRGLQGRYAKYKLMKPDCGPLEIHPTINSELLYFIRHGKIHPRSGISRFEGNTVHFTDRTQGEFDT
IIFATGYQISFPFFDKSCIDFSNSTTIPLYRKMMHPEFENLYFIGLCQPQGCIWPLADYQSKIVARIIAGTLKRPDQLHR
KIAKEINKPHHRFKSHMRHALEVDYHIFRKELLEMLGQKHKRLKFYP
>Mature_447_residues
MMEIKRVLKDRLSARVCVIGAGPSGIAAIKNLQEHGITNVTVFEKNNQIGGNWVYDEQNEHSSVYETTHIISSKRWSEFE
DFPMPVDYPDYPSHSQLLKYFQSYVEHFHLDRYIRFNTVVQKVHRLDDNTWHVIYEDAQGIHEACYDYLLVANGHHWDPF
MPVYPGVFDGEILHSHQYKKASIFKGKRVLVVGGGNSACDVAVEISRVAPGTCISMRRGYHIFPKFIFGKPTDVAVAKIQ
WMPSWLRQKFISLVIRGLQGRYAKYKLMKPDCGPLEIHPTINSELLYFIRHGKIHPRSGISRFEGNTVHFTDRTQGEFDT
IIFATGYQISFPFFDKSCIDFSNSTTIPLYRKMMHPEFENLYFIGLCQPQGCIWPLADYQSKIVARIIAGTLKRPDQLHR
KIAKEINKPHHRFKSHMRHALEVDYHIFRKELLEMLGQKHKRLKFYP

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Can oxidize a wide range of acetophenone derivatives. Highest activity occurs with co

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503755, Length=453, Percent_Identity=33.5540838852097, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI221316672, Length=457, Percent_Identity=32.3851203501094, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4503757, Length=448, Percent_Identity=32.1428571428571, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI221316674, Length=427, Percent_Identity=32.7868852459016, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI50541965, Length=451, Percent_Identity=32.5942350332594, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI50541961, Length=451, Percent_Identity=32.5942350332594, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4503759, Length=404, Percent_Identity=32.4257425742574, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI221316678, Length=231, Percent_Identity=38.0952380952381, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI25145785, Length=454, Percent_Identity=32.15859030837, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25150462, Length=448, Percent_Identity=30.8035714285714, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17561948, Length=445, Percent_Identity=30.7865168539326, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17555726, Length=445, Percent_Identity=31.9101123595506, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17541300, Length=446, Percent_Identity=31.390134529148, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193202226, Length=222, Percent_Identity=32.8828828828829, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17506045, Length=218, Percent_Identity=34.4036697247706, Blast_Score=114, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6321970, Length=188, Percent_Identity=28.7234042553192, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921694, Length=212, Percent_Identity=35.8490566037736, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922866, Length=233, Percent_Identity=33.4763948497854, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.84 [H]

Molecular weight: Translated: 52021; Mature: 52021

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEIKRVLKDRLSARVCVIGAGPSGIAAIKNLQEHGITNVTVFEKNNQIGGNWVYDEQNE
CCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCC
HSSVYETTHIISSKRWSEFEDFPMPVDYPDYPSHSQLLKYFQSYVEHFHLDRYIRFNTVV
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKVHRLDDNTWHVIYEDAQGIHEACYDYLLVANGHHWDPFMPVYPGVFDGEILHSHQYKK
HHHHHCCCCEEEEEECCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCH
ASIFKGKRVLVVGGGNSACDVAVEISRVAPGTCISMRRGYHIFPKFIFGKPTDVAVAKIQ
HHCCCCCEEEEEECCCCCEEEEEEEECCCCCCEEHHCCCCEECCHHHCCCCCCCEEEEEH
WMPSWLRQKFISLVIRGLQGRYAKYKLMKPDCGPLEIHPTINSELLYFIRHGKIHPRSGI
HCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCHHHEEHHHCCCCCCCCCC
SRFEGNTVHFTDRTQGEFDTIIFATGYQISFPFFDKSCIDFSNSTTIPLYRKMMHPEFEN
HHCCCCEEEEECCCCCCEEEEEEEECCEEECCCCCCHHHCCCCCCCHHHHHHHHCCCCCC
LYFIGLCQPQGCIWPLADYQSKIVARIIAGTLKRPDQLHRKIAKEINKPHHRFKSHMRHA
EEEEEEECCCCCEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LEVDYHIFRKELLEMLGQKHKRLKFYP
HHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMEIKRVLKDRLSARVCVIGAGPSGIAAIKNLQEHGITNVTVFEKNNQIGGNWVYDEQNE
CCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCC
HSSVYETTHIISSKRWSEFEDFPMPVDYPDYPSHSQLLKYFQSYVEHFHLDRYIRFNTVV
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKVHRLDDNTWHVIYEDAQGIHEACYDYLLVANGHHWDPFMPVYPGVFDGEILHSHQYKK
HHHHHCCCCEEEEEECCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCH
ASIFKGKRVLVVGGGNSACDVAVEISRVAPGTCISMRRGYHIFPKFIFGKPTDVAVAKIQ
HHCCCCCEEEEEECCCCCEEEEEEEECCCCCCEEHHCCCCEECCHHHCCCCCCCEEEEEH
WMPSWLRQKFISLVIRGLQGRYAKYKLMKPDCGPLEIHPTINSELLYFIRHGKIHPRSGI
HCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCHHHEEHHHCCCCCCCCCC
SRFEGNTVHFTDRTQGEFDTIIFATGYQISFPFFDKSCIDFSNSTTIPLYRKMMHPEFEN
HHCCCCEEEEECCCCCCEEEEEEEECCEEECCCCCCHHHCCCCCCCHHHHHHHHCCCCCC
LYFIGLCQPQGCIWPLADYQSKIVARIIAGTLKRPDQLHRKIAKEINKPHHRFKSHMRHA
EEEEEEECCCCCEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LEVDYHIFRKELLEMLGQKHKRLKFYP
HHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11322873 [H]