Click here to switch to the map view.

The map label for this gene is cl

Identifier: 52841054

GI number: 52841054

Start: 895915

End: 898188

Strand: Direct

Name: cl

Synonym: lpg0818

Alternate gene names: 52841054

Gene position: 895915-898188 (Clockwise)

Preceding gene: 52841053

Following gene: 52841055

Centisome position: 26.37

GC content: 39.71

Gene sequence:

>2274_bases
ATGACAATGTTAAATAAAGAACTAGAATTCACCTTGAATCTAGCTTTCAAGGAAGCAAAAGAAAAGCGTCATGAGTTCAT
GACTGTTGAACATTTGCTGTTGTCTTTGCTTGATAATCCAGCAGCAGGAAATGTATTACAAGCTTGTGATGCTAACATCG
AGGCATTACGTCGTGATTTGATCGAATTTATTGATGAAACAACCCCAAGAATTCCTGAGGATGAATTGGACAGGGAAACT
CAACCAACATTAGGTTTTCAAAGGGTTTTACAGCGTGCAGTATTTCATGTGCAATCAGCAGGCAAAACGGAAGTCACTGG
AGCTAATGTATTAGCCGCAATTTTTAGTGAGCAAGAAAGTCAGGCTGTATATTTTTTGCGACGTGAAAATATTACTCGCC
TTGATGTCATTAATTATATTTCTCATGGAGTGTCAAAATATCAAAACAATGATATGCATGAAAACATGAATTCATCTATG
GAAGAAGACATGATGACCCCTGAGGGTAATGAGTCTCCACTTGATAGTTATTGCACCAATCTCAACAGACGTGCAAAACA
GGGCAAGATAGATCCATTGATAGGGCGGCATGAAGAGATACAAAGAACTATACAAGTGCTTTGCAGACGCCGTAAAAATA
ATCCTTTATTAGTTGGCGAGGCAGGTGTAGGTAAAACTGCTATCGCAGAAGGTTTGGCCAGACGTATAGTGGATGGTGAA
ATCCCAGATTCCATAAGAGGCTGCGTAGTCTACTCTCTTGATTTGGGCGCGTTATTGGCAGGAACGAAATACAGAGGGGA
TTTTGAAAAACGATTGAAAGCTGTGCTGAAACAGTTGGGTCAGCAAGAAGGAGCCATTTTATTCATAGATGAAATTCACA
CCATTATTGGAGCAGGTGCTGCATCTGGAGGAGTCATGGATGCTTCCAACCTGATTAAGCCATTATTGGCAAATGGTGAA
TTGAAATGTATTGGCTCAACTACTTATCAGGAATATCGTGGAATATTTGAAAAAGACAGGGCCTTGGCAAGACGATTCCA
AAAAATTGATATTTCAGAACCAACAATCGATGAAACTTTTGAAATATTAAAAGGATTAAAAGGCAAATTGGAAGCTCACC
ATGGAGTAAAATTTTCAATTCCTTCATTAAAAGCGGCAGCAGAATTATCTGCAAAATACATCAATGATCGATTTTTGCCT
GACAAAGCGATTGATGTGGTGGATGAAGCGGGCGCTTATCAGAATTTATTGACGGCAAATAAACGTAAAAAAATTATAAG
CGTGACTGAAATCGAGAGTGTTGTCGCAAAAATTGCTCGTATCCCAATTAAAAAGGTATCTGCGCGCGACAAAGATACTC
TGCGTAACCTGGAACGTGATTTAAAATTATTGGTCTATGGTCAAGACCAGGCAATTACTGCCTTGGCTTCAGCAATCAAA
TTGGGTAGATCCGGACTTAGAGAACCTCAGAAGCCAGTAGGTTGTTTCTTGTTTGCCGGACCAACTGGTGTAGGAAAGAC
AGAGGTAACAAGGCAACTGGCTAATGTGTTAGGCATAGAGTTGCTGCGTTTTGATATGTCTGAGTACATGGAAAAACACA
CTGTTTCACGTTTGATAGGAGCACCTCCTGGCTATGTAGGATACGATCAAGGTGGTTTATTGACTGAAGCCGTGACTAAG
AATCCACATGCTGTTCTGCTACTTGATGAAATAGAAAAAGCACATCCTGATGTCTTTAATTTATTGTTGCAGATAATGGA
TCATGGCACTTTAACTGATACCAACGGTCGTCAAGCTGATTTCAGACATATCATACTTGTAATGACCAGTAACGCAGGGG
CCAGTGAAATTGTTCGTAACTCCATAGGTTTTTCAACGCAAGACAATACCAATGATGGGTTGGAAGTAATTAAAAAGCAA
TTCAGTCCTGAGTTTAGGAACCGTTTGGATGCTATTATCAATTTTGCACCGTTAGATACTCAGACTATAGGACTAGTTGT
TGATAAATTCATTATGGAGTTGGATGAACAATTAAGTCATAAAGGCGTTACTTTTACAGTTGATAAGTCAGCCAGGGAAT
GGCTGATGGAGCATGGTTATGATAAAGCCATGGGAGCACGACCTATGGCCAGATTGATTCAGGAAAATATCAAAAAGCCT
CTTGCTGATGAACTGTTGTTTGGTAAATTAATGCATGGTGGTCATGTCACTTTGCGAGTGAAAGACGGTAAACTGCATTT
TGACAGTCATGATCATAGAGAAGGTGTTTGTTAA

Upstream 100 bases:

>100_bases
ACAAAAGTCGCCCTGGTAAATGAATACGCCAGAATGAATCAACATCCATTATTATCTAGTATGGAACCGGAGTAAACTGG
TGGTGGGTTGGTAAGGAGCA

Downstream 100 bases:

>100_bases
ACGGAAACCCTCTTCAGTTCTGTGCATGACAAATTTTTTGTTATGCACAGACAAAATCACAATAATTATGAGATAGTAAT
TGTCATTAACCTGTTAGTTG

Product: ATP binding protease component ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 756

Protein sequence:

>757_residues
MTMLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRET
QPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSM
EEDMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGE
IPDSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLIKPLLANGE
LKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLP
DKAIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIK
LGRSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTK
NPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQ
FSPEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKP
LADELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC

Sequences:

>Translated_757_residues
MTMLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRET
QPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSM
EEDMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGE
IPDSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLIKPLLANGE
LKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLP
DKAIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIK
LGRSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTK
NPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQ
FSPEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKP
LADELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
>Mature_756_residues
TMLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQ
PTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSME
EDMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEI
PDSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLIKPLLANGEL
KCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPD
KAIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKL
GRSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKN
PHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQF
SPEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPL
ADELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=317, Percent_Identity=31.8611987381703, Blast_Score=157, Evalue=4e-38,
Organism=Escherichia coli, GI1787109, Length=739, Percent_Identity=66.7117726657645, Blast_Score=1016, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=411, Percent_Identity=44.7688564476886, Blast_Score=305, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=45.565749235474, Blast_Score=280, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=419, Percent_Identity=39.3794749403341, Blast_Score=265, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84308; Mature: 84177

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHH
IEFIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQES
HHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
QAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEEDMMTPEGNESPLDSYCTN
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHH
LNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCC
IPDSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGA
CCCCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCC
ASGGVMDASNLIKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETF
CCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTAN
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
KRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIK
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
LGRSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIG
HHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQAD
CCCCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC
FRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDT
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
QTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKP
HHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCH
LADELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
HHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC
>Mature Secondary Structure 
TMLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHH
IEFIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQES
HHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
QAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEEDMMTPEGNESPLDSYCTN
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHH
LNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCC
IPDSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGA
CCCCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCC
ASGGVMDASNLIKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETF
CCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTAN
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
KRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIK
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
LGRSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIG
HHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQAD
CCCCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC
FRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDT
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
QTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKP
HHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCH
LADELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
HHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]