Click here to switch to the map view.

The map label for this gene is dsbD

Identifier: 52840923

GI number: 52840923

Start: 737789

End: 739579

Strand: Reverse

Name: dsbD

Synonym: lpg0686

Alternate gene names: 52840923

Gene position: 739579-737789 (Counterclockwise)

Preceding gene: 52840928

Following gene: 52840922

Centisome position: 21.77

GC content: 41.21

Gene sequence:

>1791_bases
ATGTTTATTAGTAACAGTAAAAGATATCGAATGAAAAAATGGCTCTTATTTTCCCTATTATTTTTAACTTCCCTTTGTGT
TCATGCTGAGCCCTTGCCAGCTTCTGAAGTATTTAAGGTTAGTGTAAAAAAAATAGACCCCAATACCTTTGCCATACAAT
GGAATATCTTGCCCAAGTATTTTTTATATAGCGACCGTATTCAATTAAATTCCGATAATGATGACATTGCACAGCTTGGA
ACTCTTCGCTTCCCCACCCCCTTAACCAAAACGGATAAACAAGGGCGAACCTTTAAAGTTTATCGCAATCAGCTTAACCT
TCCAGTGGGAGTCCTGGGCATTACCCCAGGAGAAACAATAGTCAATTTGCGTTTTCAAGGATGTGCCGACGATGGTTTTT
GTTATCCCCCCGAAGTAAAACAAATCAAACTGGCAATTGACGATAAACTGGCTCTTTCTCAAGTTGATTTGGAAACATTC
CATGCACCTGAAGCAACACCTCTTGAAAAACCGCAACAAGACATCGCTGATATTTTTGCAAATCATAATTGGATAATGAT
TCTGCTTATATTTTACGGGTTTGGCCTGCTTTTATCCTTCACTCCTTGTATACTTCCCATGGTTCCTGTCCTTTCAGGCA
TTATTGTTGGTCATGGGAAAACGGCAACCACGAAAAAAGCATTTTTCCTGTCATTAAGCTACGTGCTCAGCATGTCCGTC
ACTTATGCCGTTGTGGGTGCTGTCGTTGCCCTGCTTGGAGCCAATTTACAAATCAGTATGCAATCACCTTGGGCTATCAG
TCTATTCAGTCTGATATTCGTTTTGCTGGCCTTGTCCATGTTTGGCTTTTATGAATTCAAACTGCCAGATGCATGGCAAA
GCAAAATTGTAGGTTCAAGTCGTGAACAACGTGGTGGACACTATCTTGGGGCAGCCATCATGGGATGTTTGTCCACACTC
ATTCTGTCACCATGTGTTACAGCACCATTAATTGGAGTATTAACCTACATAGCACAAACCGGAAACGTATTACTCGGCAG
TGTCACTCTATTTACATTAAGCCTCGGCATGGGTACTCCATTACTGCTGATAGGAACTTCTGCTGGTAAATGGCTACCCG
AAACAGGAAGCTGGATGAATGCTGTTAAAGCTTTTTTTGGCATATTACTTCTTGCTGTTGCCATCTATCTGATGGCACGC
ATTTTACCAGCAGGTTTGGTCATGGGGCTATGGGCTTGTCTCCTGATCTTTTCCGGCATTTACTCTGGTGCCTTAACCAA
ATCGAATACCAACCAGGAAAAGCTCTGCCAAGGCATTGGTATCATTTTATTAACCTATGGATTGCTGATTCTCATTGGAG
CTAGCATGGGCTCTTCCAACCCTTTGCAGCCTTTAGCCAACTTACAAGCAGCCCCTACTGTAAGCAATGCTTTTGAATCA
GCTAAAGCCCAATCTGTTAAAAGTGTTGAACTGGCTATAAAACAAGCGTTCGGAAAACCAGTGATGCTTGATTTTTATGC
TGACTGGTGTGCATCATGTAAAGTAATGGAAAACACCACGTTCAAAGATCCTCGTGTACAAAAAGCTTTGAGCCATTTTA
TCGTTATCAAAGTGGATGTGACTGCCAATAATAAAAATGACAAAGCATTAATGCAGCATTTCCGTGTAGTAGCCCCCCCG
ACTTTTATCTTTTTTAATGCTGATGGCGTACAACTCAATAATTTGAAAAGAGTTGGTGAATTGAACGCCGATGAATTCAT
GCAAACCATAAAAAGCATTGATGAGAACTAA

Upstream 100 bases:

>100_bases
GGGCAAACAATACCGATGACAGCGATATGGGGACAATAAACAAACTTTCAAGGGTAAAATCAAAAAAAATTTTGGATTTG
GGATTACAGAGTCTACAATA

Downstream 100 bases:

>100_bases
AGTAACTACGGACACTTTTGTATGAAATCAGTCGACACTCGAACGATTAAGCAGTATAATTAGCTCATTTTTTTTACAGA
TAGAAGTTTATGAATCATAA

Product: hypothetical protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MFISNSKRYRMKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLNSDNDDIAQLG
TLRFPTPLTKTDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETF
HAPEATPLEKPQQDIADIFANHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSV
TYAVVGAVVALLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLGAAIMGCLSTL
ILSPCVTAPLIGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMAR
ILPAGLVMGLWACLLIFSGIYSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFES
AKAQSVKSVELAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDKALMQHFRVVAPP
TFIFFNADGVQLNNLKRVGELNADEFMQTIKSIDEN

Sequences:

>Translated_596_residues
MFISNSKRYRMKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLNSDNDDIAQLG
TLRFPTPLTKTDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETF
HAPEATPLEKPQQDIADIFANHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSV
TYAVVGAVVALLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLGAAIMGCLSTL
ILSPCVTAPLIGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMAR
ILPAGLVMGLWACLLIFSGIYSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFES
AKAQSVKSVELAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDKALMQHFRVVAPP
TFIFFNADGVQLNNLKRVGELNADEFMQTIKSIDEN
>Mature_596_residues
MFISNSKRYRMKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLNSDNDDIAQLG
TLRFPTPLTKTDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETF
HAPEATPLEKPQQDIADIFANHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSV
TYAVVGAVVALLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLGAAIMGCLSTL
ILSPCVTAPLIGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMAR
ILPAGLVMGLWACLLIFSGIYSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFES
AKAQSVKSVELAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDKALMQHFRVVAPP
TFIFFNADGVQLNNLKRVGELNADEFMQTIKSIDEN

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=563, Percent_Identity=33.9253996447602, Blast_Score=336, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 65301; Mature: 65301

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISNSKRYRMKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKY
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCEEEEEEECCCCC
FLYSDRIQLNSDNDDIAQLGTLRFPTPLTKTDKQGRTFKVYRNQLNLPVGVLGITPGETI
CEEECEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEECCCCEE
VNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETFHAPEATPLEKPQQDIADIFA
EEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
NHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHH
TYAVVGAVVALLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSS
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCC
REQRGGHYLGAAIMGCLSTLILSPCVTAPLIGVLTYIAQTGNVLLGSVTLFTLSLGMGTP
CHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCC
LLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMARILPAGLVMGLWACLLIFSGI
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFES
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHH
AKAQSVKSVELAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDV
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCEEECCCCCCCHHHHHHHCCEEEEEEEE
TANNKNDKALMQHFRVVAPPTFIFFNADGVQLNNLKRVGELNADEFMQTIKSIDEN
ECCCCCHHHHHHHHHHCCCCEEEEECCCCCEECCHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFISNSKRYRMKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKY
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCEEEEEEECCCCC
FLYSDRIQLNSDNDDIAQLGTLRFPTPLTKTDKQGRTFKVYRNQLNLPVGVLGITPGETI
CEEECEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEECCCCEE
VNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETFHAPEATPLEKPQQDIADIFA
EEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
NHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHH
TYAVVGAVVALLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSS
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCC
REQRGGHYLGAAIMGCLSTLILSPCVTAPLIGVLTYIAQTGNVLLGSVTLFTLSLGMGTP
CHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCC
LLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMARILPAGLVMGLWACLLIFSGI
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFES
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHH
AKAQSVKSVELAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDV
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCEEECCCCCCCHHHHHHHCCEEEEEEEE
TANNKNDKALMQHFRVVAPPTFIFFNADGVQLNNLKRVGELNADEFMQTIKSIDEN
ECCCCCHHHHHHHHHHCCCCEEEEECCCCCEECCHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA