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The map label for this gene is adhc1 [H]

Identifier: 52840849

GI number: 52840849

Start: 645622

End: 646668

Strand: Reverse

Name: adhc1 [H]

Synonym: lpg0612

Alternate gene names: 52840849

Gene position: 646668-645622 (Counterclockwise)

Preceding gene: 52840850

Following gene: 52840847

Centisome position: 19.03

GC content: 42.22

Gene sequence:

>1047_bases
ATGTCAGAAACTATTGGTTATGCCGCCCACAAAGCGGGAGCCCCTTTAAAACCTTTCACTTTTGAACGCCGCCCTGTTGG
TGCACACGACGTAGCAATTGATATTCTATTTTGTGGTATCTGTCATTCCGATTTGCATCAAGTCAATAATGATTGGGCAG
GAGCATTCTATCCTATGGTTCCTGGACATGAAATCATTGGACGAGTCAAGGAGGTAGGACATCAAGTCCGCCGGTTCAAA
GCAGGAGATTTAGTGGGCGTTGGCTGTATGGTTGACTCCTGCCGTCAATGCACCTATTGCCATCAGCATGAAGAACAATA
TTGCAAATCTGGAGCAACTTTTACCTATAATAGTCAAGACAATCATCTGGGAGGGGTGACCTACGGGGGGTATTCCAAAC
ATATTGTCGTCACTGAAGATTTTGTATTAAAAATTGATGAATCACTTGATCCTGCCGCCGCCGCACCATTACTCTGTGCC
GGAATAACCACTTATTCCCCCTTGAAAAGGGCTAAAGTAGGTAAAATGAGTAAAGTAGGAATCGTAGGCCTGGGTGGCTT
AGGACATATGGCTGTCAAATTAGCCCGTGCCATGGGGGCTTATGTGACTGTATTTACCACTTCTATAAACAAGATAAAAG
CGGGTAAAGATTTGGGAGCTCATGATGTTGTCTTGTCTACCGACAACAATGTCATGCAAACACTAGCCAATCAATATGAT
TTTATTCTTGATACTGTTTCTGCCAAACATGATCTTGGCCAATATTTAAACCTTCTTAAAGTGGATGGACAACTAACCCA
GGTTGGGCTTCCATCAGATCCACTTGAAGTTACCATGTTTCCTGTTATTTTAAAAAGACTGAGCATTAACGGCTCATTGA
TTGGCGGCATTAAAGAGACACAAGAAGTTTTGGATTTTTGCGCCAGGCATGGGATCACCGCAGACATTGAATTAATAAAA
ATGCATGAAGTAAATTCTGCCTACGAAAGACTGTTAAAAGGAGATGTGAAATATCGATTTGTTATCGATATGTCAACCCT
GGATTAA

Upstream 100 bases:

>100_bases
TTAATGAGGGAGTTTAGATAAACTAAACAACCGAATTAAAAACATTTTCTAACAAAGAGATTGGGGGTATGTCCTGATTA
TAATTTTTTAAGGACAAAAA

Downstream 100 bases:

>100_bases
ATGAACCCGGTATAAAAGGCTTCCAGTTGGCCTTTTATACCACGGAGCAAATATTATTCCTAGTTTTTAATCTTGGGGAA
AACTTTAATTTTGGTTATAA

Product: alcohol dehydrogenase (NADP-dependent, zinc-type)

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMVPGHEIIGRVKEVGHQVRRFK
AGDLVGVGCMVDSCRQCTYCHQHEEQYCKSGATFTYNSQDNHLGGVTYGGYSKHIVVTEDFVLKIDESLDPAAAAPLLCA
GITTYSPLKRAKVGKMSKVGIVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDNNVMQTLANQYD
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKETQEVLDFCARHGITADIELIK
MHEVNSAYERLLKGDVKYRFVIDMSTLD

Sequences:

>Translated_348_residues
MSETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMVPGHEIIGRVKEVGHQVRRFK
AGDLVGVGCMVDSCRQCTYCHQHEEQYCKSGATFTYNSQDNHLGGVTYGGYSKHIVVTEDFVLKIDESLDPAAAAPLLCA
GITTYSPLKRAKVGKMSKVGIVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDNNVMQTLANQYD
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKETQEVLDFCARHGITADIELIK
MHEVNSAYERLLKGDVKYRFVIDMSTLD
>Mature_347_residues
SETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMVPGHEIIGRVKEVGHQVRRFKA
GDLVGVGCMVDSCRQCTYCHQHEEQYCKSGATFTYNSQDNHLGGVTYGGYSKHIVVTEDFVLKIDESLDPAAAAPLLCAG
ITTYSPLKRAKVGKMSKVGIVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDNNVMQTLANQYDF
ILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKETQEVLDFCARHGITADIELIKM
HEVNSAYERLLKGDVKYRFVIDMSTLD

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=323, Percent_Identity=27.5541795665635, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501933, Length=353, Percent_Identity=28.8951841359773, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI4501929, Length=353, Percent_Identity=28.328611898017, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI34577061, Length=354, Percent_Identity=28.5310734463277, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI71565154, Length=239, Percent_Identity=28.8702928870293, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71743840, Length=313, Percent_Identity=25.2396166134185, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI262073058, Length=313, Percent_Identity=25.2396166134185, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI156523966, Length=235, Percent_Identity=28.0851063829787, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501939, Length=235, Percent_Identity=28.0851063829787, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786518, Length=341, Percent_Identity=55.7184750733138, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=34.593023255814, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI87081918, Length=311, Percent_Identity=28.6173633440514, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790045, Length=277, Percent_Identity=27.0758122743682, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788075, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=26.2390670553936, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790718, Length=272, Percent_Identity=26.8382352941176, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788073, Length=265, Percent_Identity=26.0377358490566, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788407, Length=276, Percent_Identity=26.4492753623188, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082125, Length=221, Percent_Identity=27.6018099547511, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=338, Percent_Identity=30.4733727810651, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=27.906976744186, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=343, Percent_Identity=27.4052478134111, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=363, Percent_Identity=26.7217630853994, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=365, Percent_Identity=26.5753424657534, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=23.3236151603499, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=25.8160237388724, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=346, Percent_Identity=35.5491329479769, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319949, Length=346, Percent_Identity=34.393063583815, Blast_Score=175, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6323729, Length=333, Percent_Identity=29.4294294294294, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=334, Percent_Identity=28.1437125748503, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=28.4403669724771, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=28.5276073619632, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=27.445652173913, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=282, Percent_Identity=29.7872340425532, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=282, Percent_Identity=29.7872340425532, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=285, Percent_Identity=24.5614035087719, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=230, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=25.4794520547945, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137530, Length=249, Percent_Identity=28.9156626506024, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37930; Mature: 37799

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMV
CCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
PGHEIIGRVKEVGHQVRRFKAGDLVGVGCMVDSCRQCTYCHQHEEQYCKSGATFTYNSQD
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
NHLGGVTYGGYSKHIVVTEDFVLKIDESLDPAAAAPLLCAGITTYSPLKRAKVGKMSKVG
CCCCCEEECCCCCEEEEECCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
IVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDNNVMQTLANQYD
EEEECCHHHHHHHHHHHHCCEEEEEEECHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHH
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKET
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHH
QEVLDFCARHGITADIELIKMHEVNSAYERLLKGDVKYRFVIDMSTLD
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCCC
>Mature Secondary Structure 
SETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMV
CCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
PGHEIIGRVKEVGHQVRRFKAGDLVGVGCMVDSCRQCTYCHQHEEQYCKSGATFTYNSQD
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
NHLGGVTYGGYSKHIVVTEDFVLKIDESLDPAAAAPLLCAGITTYSPLKRAKVGKMSKVG
CCCCCEEECCCCCEEEEECCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
IVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDNNVMQTLANQYD
EEEECCHHHHHHHHHHHHCCEEEEEEECHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHH
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKET
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHH
QEVLDFCARHGITADIELIKMHEVNSAYERLLKGDVKYRFVIDMSTLD
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]