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The map label for this gene is gor

Identifier: 52840815

GI number: 52840815

Start: 613930

End: 615294

Strand: Reverse

Name: gor

Synonym: lpg0578

Alternate gene names: 52840815

Gene position: 615294-613930 (Counterclockwise)

Preceding gene: 52840817

Following gene: 52840814

Centisome position: 18.11

GC content: 38.46

Gene sequence:

>1365_bases
TTGACTATGAAAACAAAACATTTTGACCTTATAGTTCTTGGAGGAGGAAGTGGCGGAATAGCTAGTGCTGTTCGTGCTGC
TCAGTATGGAGCCAAAGTAGCAGTTATTGAACAAAACCACTTGGGAGGGACCTGCGTGAATTTAGGATGTGTCCCCAAAA
AAATTATGTACAATGCTTCATCAATTGCAGAAACACTCCATAAATCTCCTGATTACGGTTTTTTCCTGGAAAATAATGCC
AAGTTAGATTGGAAGCGACTAGTGAATAAACGCAATGCGTATATTGAACGTTTAAGAGAAAATTATGAGAAACGATTTTC
ACAGCACAAAATTACTCTGATTCAAGGTAAGGGCATTTTCCACGATCAAAGTTCTATCACGATAGATCATACTATTTATC
AAGCAGAACATATTATTATTGCAACTGGCAGTGAGCCAGCTCTACCAGCAATTAATGGCATTAAGCATGCTATTGATTCT
GATGGTTTCTTTTCATTAACCAAATTACCAGCTAAGGTAGCTGTTATTGGTAGCGGTTACATAGGTGTTGAATTAGCAGG
AATCCTTAACTCTCTTGGTAGTGAAACTCACTTATTAATGAGAGGTACACGGCCACTGAGTCGCTTTGATCATATGATTG
GCGATACTTTAATGGAAATTATGCAAAAACAAGGAATCTGTATTCATCAAAACCATAAAGCCCAAGCTATCCATCTCCAT
AGCGACGGCAGAAAAAGTATTTTGTGCCAAAGTGGCTCTATTATTGAAAATATTGATGTCATTATATCTGCTGTAGGTCG
AAAACCGCGGACTGGCAATTTAAATCTTGATAAAATAAACGTTAACATGGATGACAAAGGATTAATCCTGGTTGATGCAT
TCCAAAATACATCGGTTAAAGGTATTTATGCTATTGGCGATGTCACTAATGCTCCCGCACTAACTCCCGTTGCAATAGCG
GCAGGGAGGCGTTTGGCAGACCGAATTTTCGGGAATCAACCTGATGCCTGCTTAAATTATGATAATATTTGTTCAGTAGT
GTTCTCTCATCCTCCATCTGGTTCTGTCGGTTTAACCGAGCATGAAGCCATTGAAAAATATGGTAAGAATAAAATTAAAA
TATATCAAACCCGTTTCATCCCTATGTATGATGCCTTGAGTATTGATAAAACCCCTACTGCGATGAAATTGGTTACCTTG
GGTAAAAAGGAAAAGATTATTGGTTTACATGTCGTCGGATACAGCGCCGATGAAATGCTACAAGGCTTTGGGGTTGCCAT
AAAAATGGGCGCATGTAAAAAGGACTTCGATAATACAATTGCAATTCATCCAACCAGTGCTGAAGAATTTGTAACTATGG
TGTAA

Upstream 100 bases:

>100_bases
CTGGTTGAAATTAAAAAATATTTTAGTTTTTTATAAAATTCAGTTTAATCCCTTGGTAGACCAAGTACGACCTGCTACTA
TTATTTTATTTTCCTATTAA

Downstream 100 bases:

>100_bases
ATATACATGAACTATTCCATTCGTAAATTTGAAGACAAGTATCCTGAATTAGGTGAACGAGTTTATATTGATCCGCAATC
CACTGTCATTGGTAACGTAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTMKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNA
KLDWKRLVNKRNAYIERLRENYEKRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGSEPALPAINGIKHAIDS
DGFFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLH
SDGRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGIYAIGDVTNAPALTPVAIA
AGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTL
GKKEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV

Sequences:

>Translated_454_residues
MTMKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNA
KLDWKRLVNKRNAYIERLRENYEKRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGSEPALPAINGIKHAIDS
DGFFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLH
SDGRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGIYAIGDVTNAPALTPVAIA
AGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTL
GKKEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
>Mature_453_residues
TMKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNAK
LDWKRLVNKRNAYIERLRENYEKRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGSEPALPAINGIKHAIDSD
GFFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHS
DGRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGIYAIGDVTNAPALTPVAIAA
GRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLG
KKEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=47.1615720524017, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI22035672, Length=457, Percent_Identity=33.4792122538293, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=34.9450549450549, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=34.9450549450549, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=34.9450549450549, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=34.9450549450549, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=34.9450549450549, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=31.9474835886214, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=29.1028446389497, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=30.7017543859649, Blast_Score=188, Evalue=1e-47,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=51.5555555555556, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=28.159645232816, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=26.2693156732892, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=27.3318872017354, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=34.3881856540084, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI32565766, Length=473, Percent_Identity=28.9640591966173, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=45.9574468085106, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=28.9699570815451, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=25.7446808510638, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=33.4042553191489, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=33.4042553191489, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=33.4042553191489, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=33.2627118644068, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=29.1938997821351, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49493; Mature: 49362

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNAS
CCCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHCCHH
SIAETLHKSPDYGFFLENNAKLDWKRLVNKRNAYIERLRENYEKRFSQHKITLIQGKGIF
HHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEE
HDQSSITIDHTIYQAEHIIIATGSEPALPAINGIKHAIDSDGFFSLTKLPAKVAVIGSGY
ECCCCEEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEECCC
IGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLH
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEE
SDGRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVK
CCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCE
GIYAIGDVTNAPALTPVAIAAGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTE
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEECCCCCCCCCCCH
HEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGKKEKIIGLHVVGYSADEML
HHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHH
QGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
HCCCEEEEECCCCCCCCCEEEEECCCHHHHEECC
>Mature Secondary Structure 
TMKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNAS
CCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHCCHH
SIAETLHKSPDYGFFLENNAKLDWKRLVNKRNAYIERLRENYEKRFSQHKITLIQGKGIF
HHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEE
HDQSSITIDHTIYQAEHIIIATGSEPALPAINGIKHAIDSDGFFSLTKLPAKVAVIGSGY
ECCCCEEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEECCC
IGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLH
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEE
SDGRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVK
CCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCE
GIYAIGDVTNAPALTPVAIAAGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTE
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEECCCCCCCCCCCH
HEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGKKEKIIGLHVVGYSADEML
HHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHH
QGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
HCCCEEEEECCCCCCCCCEEEEECCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]