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The map label for this gene is rmlA1 [C]

Identifier: 52840550

GI number: 52840550

Start: 351696

End: 352358

Strand: Reverse

Name: rmlA1 [C]

Synonym: lpg0295

Alternate gene names: 52840550

Gene position: 352358-351696 (Counterclockwise)

Preceding gene: 52840551

Following gene: 52840547

Centisome position: 10.37

GC content: 41.18

Gene sequence:

>663_bases
ATGAAAACCGCTATGATTCTTGCAGCAGGACGTGGAGAACGATTACGCCCTTTAACCGACAAAATGCCTAAAGCACTTTG
TACGGTAAGAAACAAACCCTTAATTGAACACCATATCATTAACCTCGCCAATGCCGGCTTTGAACGATTGATAATCAATC
ATGCCTACCTGGGCGGACAAATTCGCCAATATATAGGAAATGGAAAACAATGGGGCTTAAATGTTATCTATTCTCCAGAA
CCGCCAGGAGGCCTTGAAACAGGGGGAGGGATTGTGAACGCCTTGCCTTTGCTGGGCGAAGAGCCATTTTTAACAGTAAA
TGCCGACATTTATACTGATTTTGATTTTGCCAAGCTCCAACTCAAAAATATTGATACATTTCATCTGCTTTTAATTCCCA
AAAATCCTTCTTTGCTTCATCATGGCGATTTTGGTTTAATCAATGGATCCCACTTAACCAATACAAATCAGGCTTACACT
TTTTCAGGTATTGCCTGCTATAACCCAAAGGTTTTTGCCAACTGCAGACAAGGAAGGTATTCTGTTACCCCTTTACTCAG
AAAATATGTGGAACAAAATAGTGCCACTGGAAGTGTTCACTCAGGAATTTGGTATGACATAGGCTCTTTCGATAGACTGC
AGGCAGCAAATCAGTTCACCTAA

Upstream 100 bases:

>100_bases
GGGACTTGCCTCTCACGTTAAAATATGCATTAGAATGCGCAGAAACATATGAAGAATTACACCCATTTTTTAATTTTCTG
CAAAAACGAGTTTATTTACC

Downstream 100 bases:

>100_bases
AAACCAAGATTGGTTTTTAGGTGAACCAGTATATTCCTATCTGATGGATTGAGTGGTTGGAGCTTCAGCACCGGATTCAA
TTTCTTGTCTGATTTCTTCT

Product: mannose-1-phosphate guanyltransferase

Products: dTDPglucose; Diphosphate [C]

Alternate protein names: Nucleotidyltransferase Family Protein; Nucleotidyl Transferase Family Protein; Nucleoside-Diphosphate-Sugar Pyrophosphorylase; Mannose-1-Phosphate Guanyltransferase; Nucleotidyl Transferase Superfamily; Nucleotidyltransferase; Mannose-1-Phosphate Guanylyltransferase; Sugar-Phosphate Nucleotidyl Transferase; Mannose-1-Phosphate Guanyltransferase-Related Protein; Nucleotidyltransferase Protein; Transaldolase AB; Nucleotidyl Transferase Protein; ADP-Glucose Pyrophosphorylase; Mannose-1-Phosphate Guanyltransferase Protein; Sugar-Phosphate Nucleotide Transferase; Glucose-1-Phosphate Nucleotidyltransferase; Phosphoglucomutase; Aminoglycoside Phosphotransferase; Nucleotidyl Transferase Superfamily Protein

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKTAMILAAGRGERLRPLTDKMPKALCTVRNKPLIEHHIINLANAGFERLIINHAYLGGQIRQYIGNGKQWGLNVIYSPE
PPGGLETGGGIVNALPLLGEEPFLTVNADIYTDFDFAKLQLKNIDTFHLLLIPKNPSLLHHGDFGLINGSHLTNTNQAYT
FSGIACYNPKVFANCRQGRYSVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLQAANQFT

Sequences:

>Translated_220_residues
MKTAMILAAGRGERLRPLTDKMPKALCTVRNKPLIEHHIINLANAGFERLIINHAYLGGQIRQYIGNGKQWGLNVIYSPE
PPGGLETGGGIVNALPLLGEEPFLTVNADIYTDFDFAKLQLKNIDTFHLLLIPKNPSLLHHGDFGLINGSHLTNTNQAYT
FSGIACYNPKVFANCRQGRYSVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLQAANQFT
>Mature_220_residues
MKTAMILAAGRGERLRPLTDKMPKALCTVRNKPLIEHHIINLANAGFERLIINHAYLGGQIRQYIGNGKQWGLNVIYSPE
PPGGLETGGGIVNALPLLGEEPFLTVNADIYTDFDFAKLQLKNIDTFHLLLIPKNPSLLHHGDFGLINGSHLTNTNQAYT
FSGIACYNPKVFANCRQGRYSVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLQAANQFT

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI133931050, Length=119, Percent_Identity=35.2941176470588, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355443, Length=228, Percent_Identity=27.6315789473684, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24644084, Length=228, Percent_Identity=27.6315789473684, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.7.24 [C]

Molecular weight: Translated: 24336; Mature: 24336

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAMILAAGRGERLRPLTDKMPKALCTVRNKPLIEHHIINLANAGFERLIINHAYLGGQ
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCHH
IRQYIGNGKQWGLNVIYSPEPPGGLETGGGIVNALPLLGEEPFLTVNADIYTDFDFAKLQ
HHHHHCCCCEECEEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCEEECCCEEEEE
LKNIDTFHLLLIPKNPSLLHHGDFGLINGSHLTNTNQAYTFSGIACYNPKVFANCRQGRY
ECCCCEEEEEEEECCCCEEECCCEEEEECCEECCCCCEEEECCEEEECCCEEEECCCCCE
SVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLQAANQFT
EHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHCCCCC
>Mature Secondary Structure
MKTAMILAAGRGERLRPLTDKMPKALCTVRNKPLIEHHIINLANAGFERLIINHAYLGGQ
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCHH
IRQYIGNGKQWGLNVIYSPEPPGGLETGGGIVNALPLLGEEPFLTVNADIYTDFDFAKLQ
HHHHHCCCCEECEEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCEEECCCEEEEE
LKNIDTFHLLLIPKNPSLLHHGDFGLINGSHLTNTNQAYTFSGIACYNPKVFANCRQGRY
ECCCCEEEEEEEECCCCEEECCCEEEEECCEECCCCCEEEECCEEEECCCEEEECCCCCE
SVTPLLRKYVEQNSATGSVHSGIWYDIGSFDRLQAANQFT
EHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dTTP; D-Glucose 1-phosphate; H+ [C]

Specific reaction: dTTP + D-Glucose 1-phosphate + H+ --> dTDPglucose + Diphosphate [C]

General reaction: Nucleotidyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA