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The map label for this gene is ykgC [H]

Identifier: 52840499

GI number: 52840499

Start: 288008

End: 289402

Strand: Reverse

Name: ykgC [H]

Synonym: lpg0244

Alternate gene names: 52840499

Gene position: 289402-288008 (Counterclockwise)

Preceding gene: 52840500

Following gene: 52840498

Centisome position: 8.52

GC content: 44.23

Gene sequence:

>1395_bases
ATGGTTTTAGAGTTTGATACCATCATATTAGGTGGGGGCAAAGGTGGGAAGACTCTTGCAATGGATTTGGCTAAAAGCGG
CCAGAAAATCGCGATGGTTGAAAACAATCAGATCGGTGGGACCTGTATCAATGTGGCATGCATACCTACGAAAACGCTCG
TGCAGTCAGCAAAAGTGGCACATTACTGCCGTAAAGCAAAAGACTATGGTTTAAATACTACATTGCACCCAATTGATTTT
AAAGCAATTCGAGCACGTAAAGACGCTGTGGTGAAAGGGATGCGTGAAGCGAATTTAAAACAGTTTTTAGACTCAGGCAT
GGATCTCATGTTAGGACATGGTCATTTTATTGGACCAAAAATGATTGAAGTTACCCTATCCTCACCACGTGACAAGCAAA
AAACGCTGCACATCACAGCTGATAAAATTATTATTAATACAGGCGCTCTGCCATTCATTCCCCCCATTGCGGGGCTCGAT
AAAGTCAATTATTTTACCAATGACAGTTTAATGAACACCGATTTGGTACCCCAACATTTATTGATCATCGGCGGCGGTTA
TATTGGCTTGGAATTTGCACAAATGTTTCGCCGCTTTGGTGCTGAAGTCACTGTCATCGAAGCCAGCAGCGAATTTCTTG
GCCGGGAAGACAAGGACATTGCTGAACAGGTTTTTCAAACCTTATCCAACGAAGGCATTCAATTTGCTGTCGATACAAAG
ATTAATGCCATTCGCCAAGAGCAAACTGAAGTGATTATCGAAGCTAATCGACAAGGCCAATCAGAAATTATTCGTGGCAC
AGCTGTCCTGGTTGCAGTAGGGCGTATTGCCAATACAGCAGGATTGCATTTGGATAAAACTGGCGTTGAACTTGATGAGC
GTGGATTCATCAAAGTCAATGAGTTTCTCGAAACGACAGCGGCAGGGATTTGGGCATTGGGCGATGTCAAGGGAGGGGCA
CAATTTACCCACCTGTCTCTTGATGACTATCGTCTGGTGAAACATAATTTACAAAACCCCCAGAAAAAGCTTTCTTCCCA
AAACAGGCTTATTCCTTACACAGTGTTTCTCGACCCGGAATTAGCACGCATTGGACTTACTGAAGCTCAAGCCAGATCCC
AAGGCCGCCGAATTAAAATCGCCACAATTCCGGCAGCTGCGATTCCTCGCGCCAAAACCCAAGGAGAAACAACGGGTATT
TTAAAAGCAGTCATTGACGCTGAAACCGATTTGATTTTGGGCGTTTCTATTTTCTGTGCGGAGGCAGGGGAAATATTAGG
GGTCATCCAATTAGCAATGGAGTTGCGCGTACCTTATCAAAAATTGCGCGATATGATGTTCGCTCACCCTACTCTAGTGG
AAGGCATCAATCTGTGGTTTGCGCAAATAATTTGA

Upstream 100 bases:

>100_bases
ATTTTTTATCGCCTTGCGTGAGCTTTCCTCTTTAATTCAAGTATTGTAAATAAGGATCATCATCAAGTGGATAAAACATT
GAAATTTTCGGGAGAATGGA

Downstream 100 bases:

>100_bases
ATTGATGTAAAACCATACTCGCCATATTACATGCTACAAGGCAAGTGGTTAATAGAGGCATTTTACTTCTCTTCTTCAAT
AAATCCTGTGTATAGGCAGT

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLHPIDF
KAIRARKDAVVKGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDKQKTLHITADKIIINTGALPFIPPIAGLD
KVNYFTNDSLMNTDLVPQHLLIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRRIKIATIPAAAIPRAKTQGETTGI
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII

Sequences:

>Translated_464_residues
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLHPIDF
KAIRARKDAVVKGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDKQKTLHITADKIIINTGALPFIPPIAGLD
KVNYFTNDSLMNTDLVPQHLLIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRRIKIATIPAAAIPRAKTQGETTGI
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII
>Mature_464_residues
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLHPIDF
KAIRARKDAVVKGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDKQKTLHITADKIIINTGALPFIPPIAGLD
KVNYFTNDSLMNTDLVPQHLLIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRRIKIATIPAAAIPRAKTQGETTGI
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=29.1845493562232, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=26.2820512820513, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI33519430, Length=437, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI33519428, Length=437, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI33519426, Length=437, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI148277065, Length=437, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI148277071, Length=437, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=25.219298245614, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI291045266, Length=441, Percent_Identity=26.530612244898, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI291045268, Length=437, Percent_Identity=24.9427917620137, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI65787454, Length=187, Percent_Identity=24.0641711229947, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI21389617, Length=187, Percent_Identity=24.0641711229947, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI226437568, Length=187, Percent_Identity=24.0641711229947, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=39.0086206896552, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=31.2910284463895, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI87082354, Length=455, Percent_Identity=26.1538461538462, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789915, Length=437, Percent_Identity=26.5446224256293, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI1789065, Length=186, Percent_Identity=27.4193548387097, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=30.3879310344828, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71983419, Length=377, Percent_Identity=27.8514588859416, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=27.7894736842105, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=437, Percent_Identity=25.1716247139588, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=26.2939958592132, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17559934, Length=243, Percent_Identity=27.9835390946502, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=460, Percent_Identity=31.304347826087, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=24.5689655172414, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=23.5042735042735, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=30.1518438177874, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=26.6247379454927, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=26.6247379454927, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=26.6247379454927, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI17737741, Length=478, Percent_Identity=24.4769874476987, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 50769; Mature: 50769

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVA
CEEEEEEEEEECCCCCCEEEEHHHHCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHH
HYCRKAKDYGLNTTLHPIDFKAIRARKDAVVKGMREANLKQFLDSGMDLMLGHGHFIGPK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCE
MIEVTLSSPRDKQKTLHITADKIIINTGALPFIPPIAGLDKVNYFTNDSLMNTDLVPQHL
EEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEE
LIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
EEEECCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECH
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVN
HHHHHHCCCEEEEEECCCCHHHHHHHHEEEEEHHHHCCCCCCEEECCCCCCCCCCCEEHH
EFLETTAAGIWALGDVKGGAQFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPE
HHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHCCCCCEEEEEEEECCC
LARIGLTEAQARSQGRRIKIATIPAAAIPRAKTQGETTGILKAVIDAETDLILGVSIFCA
HHHCCCCHHHHHCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
EAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVA
CEEEEEEEEEECCCCCCEEEEHHHHCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHH
HYCRKAKDYGLNTTLHPIDFKAIRARKDAVVKGMREANLKQFLDSGMDLMLGHGHFIGPK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCE
MIEVTLSSPRDKQKTLHITADKIIINTGALPFIPPIAGLDKVNYFTNDSLMNTDLVPQHL
EEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEE
LIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
EEEECCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECH
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVN
HHHHHHCCCEEEEEECCCCHHHHHHHHEEEEEHHHHCCCCCCEEECCCCCCCCCCCEEHH
EFLETTAAGIWALGDVKGGAQFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPE
HHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHCCCCCEEEEEEEECCC
LARIGLTEAQARSQGRRIKIATIPAAAIPRAKTQGETTGILKAVIDAETDLILGVSIFCA
HHHCCCCHHHHHCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
EAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]