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The map label for this gene is msrAB [H]

Identifier: 52840359

GI number: 52840359

Start: 119362

End: 119937

Strand: Reverse

Name: msrAB [H]

Synonym: lpg0104

Alternate gene names: 52840359

Gene position: 119937-119362 (Counterclockwise)

Preceding gene: 52840360

Following gene: 52840358

Centisome position: 3.53

GC content: 36.81

Gene sequence:

>576_bases
ATGTTGCGTATCCTTTTGTATTTTCTCTTACTCATTAATACAACATTTTGTCTGGCAAAGACTGAAAAAGCCATTTTTGC
AGGTGGATGTTTTTGGTGCATGGAAGCAGACTTTGACCATCTTCCTGGAGTCCTGTCCACCACATCAGGATTTGATGGGG
GCACTCTTAAAGATCCAACTTATGAACAAGTTTCCGCCGGGAATACCCATTACGCCGAATCGGTAATGGTGGAGTTTGAA
CCCAATAAATTAAGTTACAAAAAACTGGTTGAGTACTTCTTTAGGCATATTGATCCTACCGTCAAAAATGCGCAATTTTG
TGATCATGGCAGTCAATATCGCAGTGCAATTTTTTATCTTAACGATCAACAAAAGAAAATTGCCATGGAATACAAAAAAG
AGTTAGAGCAAAAATTCCCCACAGTTTATACAGAAATTGCTCCATCAACTTCTTTTTATCCGGCAGAAGAATATCATCAA
AATTATTACAAAAAAAATCCTATACGTTATAAGTATTATCGATATCGTTGTGGCCGAGATACCCGAATTCAAGAGGTTTG
GGGTAATAAAAAATAA

Upstream 100 bases:

>100_bases
ATAAGTTTTCCGAAGCCTGATTTAAAACTTTCTCTGATTTTATGCTGACTACAATACAAAATCTTGTATAATTTACAGCA
ATTCATAAAAGAGGCTTACA

Downstream 100 bases:

>100_bases
AAGAATAACTCTTAATCATGATCCATAGTTTTATCGCTTATCAAAAAAGAATAAGCAATTCATGAGAAAACACGCTAATC
TAATAAATAATAATTTTTAA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGGTLKDPTYEQVSAGNTHYAESVMVEFE
PNKLSYKKLVEYFFRHIDPTVKNAQFCDHGSQYRSAIFYLNDQQKKIAMEYKKELEQKFPTVYTEIAPSTSFYPAEEYHQ
NYYKKNPIRYKYYRYRCGRDTRIQEVWGNKK

Sequences:

>Translated_191_residues
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGGTLKDPTYEQVSAGNTHYAESVMVEFE
PNKLSYKKLVEYFFRHIDPTVKNAQFCDHGSQYRSAIFYLNDQQKKIAMEYKKELEQKFPTVYTEIAPSTSFYPAEEYHQ
NYYKKNPIRYKYYRYRCGRDTRIQEVWGNKK
>Mature_191_residues
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGGTLKDPTYEQVSAGNTHYAESVMVEFE
PNKLSYKKLVEYFFRHIDPTVKNAQFCDHGSQYRSAIFYLNDQQKKIAMEYKKELEQKFPTVYTEIAPSTSFYPAEEYHQ
NYYKKNPIRYKYYRYRCGRDTRIQEVWGNKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=41.9354838709677, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=41.9354838709677, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=40.1869158878505, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=42.1052631578947, Blast_Score=120, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.3013698630137, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=35.4037267080745, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=34.4827586206897, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=34.2857142857143, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=33.7931034482759, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 22522; Mature: 22522

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGGTLKDPT
CHHHHHHHHHHHCCHHHHHHCCCCEEECCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCC
YEQVSAGNTHYAESVMVEFEPNKLSYKKLVEYFFRHIDPTVKNAQFCDHGSQYRSAIFYL
HHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHEEEEE
NDQQKKIAMEYKKELEQKFPTVYTEIAPSTSFYPAEEYHQNYYKKNPIRYKYYRYRCGRD
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCC
TRIQEVWGNKK
CCHHHHCCCCC
>Mature Secondary Structure
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGGTLKDPT
CHHHHHHHHHHHCCHHHHHHCCCCEEECCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCC
YEQVSAGNTHYAESVMVEFEPNKLSYKKLVEYFFRHIDPTVKNAQFCDHGSQYRSAIFYL
HHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHEEEEE
NDQQKKIAMEYKKELEQKFPTVYTEIAPSTSFYPAEEYHQNYYKKNPIRYKYYRYRCGRD
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCC
TRIQEVWGNKK
CCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]