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The map label for this gene is aatA

Identifier: 52840325

GI number: 52840325

Start: 77642

End: 78820

Strand: Reverse

Name: aatA

Synonym: lpg0070

Alternate gene names: 52840325

Gene position: 78820-77642 (Counterclockwise)

Preceding gene: 52840329

Following gene: 52840318

Centisome position: 2.32

GC content: 46.4

Gene sequence:

>1179_bases
ATGGATATCGCATTGGCAAAGCGTGTACAAAAAGTAAAACCTTCACCTACCCTTGCCGTAGCTGCAAAAGCAGCTCAGAT
GAAAGCCCAGGGGCTTGATATCATTGGCCTTGGAACTGGTGAACCTGATTTTGACACGCCGCAGCATATAAAGCTAGCCG
CCATCTCTGCTATTGAAGCAGGTGATACCAAATACACCGCCGTTGATGGGATAGTCGAACTAAAGGAAGCGGTTAAAAAC
AAATTCAAAAGAGACAATGAACTGGATTATCAACTCAATCAGATATTGGTCTCCGTAGGGGGTAAACAAAGCTGCTATAA
CCTCTGCCAAGCTTACCTTAATCCTGGCGATGAAGTCATCATTCCCGCTCCTTATTGGGTATCCTATCCTGACATGGTTT
TGCTGGCTGATGGCGTTCCTGTCATCATTGAAACTACTCCCGCGCAGCGTTATAAAATCAATGCACAACAACTGGAACAA
GCCATCACTCCAAAAACACGAATGATTTTCCTGAACAGCCCTTCCAACCCCTCTGGAATAGCCTACACCCAGAACGAGTT
AAAGGAATTAGGCGACGTTTTGAAAAAACATCCACAGATACTGATTGCCACGGATGATATGTATGAACATATTATCTGGA
GCCAACCCTTTACGAACATCCTCAATGCCTGCCCTGAATTATATGACAGAACGATCGTATTAAATGGCGTGTCCAAAGCT
TATGCCATGACAGGCTGGCGGATAGGCTATGCGGCAGGCCCTGCACCATTAATCAATGCGATGAAAACCATTCAATCCCA
ATCCACATCCAATCCATGCTCCATAGCCCAAAGAGCTGCCGTAGCCGCTTTGAATGGCAGCAATGAAAGCATTGAAGAAA
TGGTGAACGCCTTCCACCAAAGGCACGACTACGTGGCCGATAGATTGCAAAGCATCGATGGCATAGAGGTCATCCCCGCC
GACGGAACTTTCTACATTTTTCCCAGTGTGCAGGCGATTATCGAAAAACGAGGTTACGCCAATGACATCGAATTTTCCGA
AAAATTGCTGAATGAAGTAGGTGTAGCACTGGTTCCAGGCTCCGCCTTCGGCACAGAAGGCTGCATCAGAATATCCTTCG
CCACCGGTATTGACACCCTGAAAGATGCCTTGAACCGATTACAACGTTTCTGCAGTTAA

Upstream 100 bases:

>100_bases
AGGTTGATCGCCGGCAGGTTGGTAATTTGAGTAAATTTTAAATAAGTCTTTCATATTTTATATTATATGCTAGTACCCCT
ATAATTCACAGGAGCAACAG

Downstream 100 bases:

>100_bases
AAAATATATTAAAAACCTCTTGATTCTCTCGCGGAATCGTTTTAAGATTCCGCCTCAATTCCCCGGTAGCTCAGTCGGTA
GAGCGGATGACTGTTAATCA

Product: aspartate aminotransferase A

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MDIALAKRVQKVKPSPTLAVAAKAAQMKAQGLDIIGLGTGEPDFDTPQHIKLAAISAIEAGDTKYTAVDGIVELKEAVKN
KFKRDNELDYQLNQILVSVGGKQSCYNLCQAYLNPGDEVIIPAPYWVSYPDMVLLADGVPVIIETTPAQRYKINAQQLEQ
AITPKTRMIFLNSPSNPSGIAYTQNELKELGDVLKKHPQILIATDDMYEHIIWSQPFTNILNACPELYDRTIVLNGVSKA
YAMTGWRIGYAAGPAPLINAMKTIQSQSTSNPCSIAQRAAVAALNGSNESIEEMVNAFHQRHDYVADRLQSIDGIEVIPA
DGTFYIFPSVQAIIEKRGYANDIEFSEKLLNEVGVALVPGSAFGTEGCIRISFATGIDTLKDALNRLQRFCS

Sequences:

>Translated_392_residues
MDIALAKRVQKVKPSPTLAVAAKAAQMKAQGLDIIGLGTGEPDFDTPQHIKLAAISAIEAGDTKYTAVDGIVELKEAVKN
KFKRDNELDYQLNQILVSVGGKQSCYNLCQAYLNPGDEVIIPAPYWVSYPDMVLLADGVPVIIETTPAQRYKINAQQLEQ
AITPKTRMIFLNSPSNPSGIAYTQNELKELGDVLKKHPQILIATDDMYEHIIWSQPFTNILNACPELYDRTIVLNGVSKA
YAMTGWRIGYAAGPAPLINAMKTIQSQSTSNPCSIAQRAAVAALNGSNESIEEMVNAFHQRHDYVADRLQSIDGIEVIPA
DGTFYIFPSVQAIIEKRGYANDIEFSEKLLNEVGVALVPGSAFGTEGCIRISFATGIDTLKDALNRLQRFCS
>Mature_392_residues
MDIALAKRVQKVKPSPTLAVAAKAAQMKAQGLDIIGLGTGEPDFDTPQHIKLAAISAIEAGDTKYTAVDGIVELKEAVKN
KFKRDNELDYQLNQILVSVGGKQSCYNLCQAYLNPGDEVIIPAPYWVSYPDMVLLADGVPVIIETTPAQRYKINAQQLEQ
AITPKTRMIFLNSPSNPSGIAYTQNELKELGDVLKKHPQILIATDDMYEHIIWSQPFTNILNACPELYDRTIVLNGVSKA
YAMTGWRIGYAAGPAPLINAMKTIQSQSTSNPCSIAQRAAVAALNGSNESIEEMVNAFHQRHDYVADRLQSIDGIEVIPA
DGTFYIFPSVQAIIEKRGYANDIEFSEKLLNEVGVALVPGSAFGTEGCIRISFATGIDTLKDALNRLQRFCS

Specific function: Required for symbiotic nitrogen fixation [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=382, Percent_Identity=26.9633507853403, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI56713256, Length=382, Percent_Identity=26.9633507853403, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI95147551, Length=422, Percent_Identity=23.4597156398104, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI169881279, Length=422, Percent_Identity=23.4597156398104, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4507369, Length=404, Percent_Identity=23.2673267326733, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI169881281, Length=417, Percent_Identity=20.863309352518, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786816, Length=369, Percent_Identity=28.4552845528455, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788722, Length=373, Percent_Identity=28.1501340482574, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788627, Length=387, Percent_Identity=24.8062015503876, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994472, Length=393, Percent_Identity=28.498727735369, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71994476, Length=393, Percent_Identity=28.498727735369, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17567369, Length=331, Percent_Identity=25.9818731117825, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17567663, Length=336, Percent_Identity=22.6190476190476, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71981209, Length=367, Percent_Identity=22.6158038147139, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=396, Percent_Identity=25.5050505050505, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28573069, Length=387, Percent_Identity=26.0981912144703, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24646114, Length=387, Percent_Identity=26.0981912144703, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28573067, Length=387, Percent_Identity=26.0981912144703, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28573065, Length=387, Percent_Identity=26.0981912144703, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI18859735, Length=382, Percent_Identity=23.8219895287958, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 42823; Mature: 42823

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIALAKRVQKVKPSPTLAVAAKAAQMKAQGLDIIGLGTGEPDFDTPQHIKLAAISAIEA
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEEHHEEC
GDTKYTAVDGIVELKEAVKNKFKRDNELDYQLNQILVSVGGKQSCYNLCQAYLNPGDEVI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEE
IPAPYWVSYPDMVLLADGVPVIIETTPAQRYKINAQQLEQAITPKTRMIFLNSPSNPSGI
ECCCCCCCCCCEEEEECCCEEEEECCCCHHEECCHHHHHHHHCCCEEEEEEECCCCCCCC
AYTQNELKELGDVLKKHPQILIATDDMYEHIIWSQPFTNILNACPELYDRTIVLNGVSKA
EECHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCHHH
YAMTGWRIGYAAGPAPLINAMKTIQSQSTSNPCSIAQRAAVAALNGSNESIEEMVNAFHQ
HHHCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHH
RHDYVADRLQSIDGIEVIPADGTFYIFPSVQAIIEKRGYANDIEFSEKLLNEVGVALVPG
HHHHHHHHHHCCCCCEEEECCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCCEEEECC
SAFGTEGCIRISFATGIDTLKDALNRLQRFCS
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIALAKRVQKVKPSPTLAVAAKAAQMKAQGLDIIGLGTGEPDFDTPQHIKLAAISAIEA
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEEHHEEC
GDTKYTAVDGIVELKEAVKNKFKRDNELDYQLNQILVSVGGKQSCYNLCQAYLNPGDEVI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEE
IPAPYWVSYPDMVLLADGVPVIIETTPAQRYKINAQQLEQAITPKTRMIFLNSPSNPSGI
ECCCCCCCCCCEEEEECCCEEEEECCCCHHEECCHHHHHHHHCCCEEEEEEECCCCCCCC
AYTQNELKELGDVLKKHPQILIATDDMYEHIIWSQPFTNILNACPELYDRTIVLNGVSKA
EECHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCHHH
YAMTGWRIGYAAGPAPLINAMKTIQSQSTSNPCSIAQRAAVAALNGSNESIEEMVNAFHQ
HHHCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHH
RHDYVADRLQSIDGIEVIPADGTFYIFPSVQAIIEKRGYANDIEFSEKLLNEVGVALVPG
HHHHHHHHHHCCCCCEEEECCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCCEEEECC
SAFGTEGCIRISFATGIDTLKDALNRLQRFCS
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2019560; 8096210; 11481430 [H]