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The map label for this gene is merR [H]

Identifier: 52840313

GI number: 52840313

Start: 64673

End: 65077

Strand: Reverse

Name: merR [H]

Synonym: lpg0057

Alternate gene names: 52840313

Gene position: 65077-64673 (Counterclockwise)

Preceding gene: 52840318

Following gene: 52840310

Centisome position: 1.92

GC content: 34.57

Gene sequence:

>405_bases
ATGAATAATAAAAAAATTGGTGAATTTGCTAAATTATGTGGAGTTGGCATTGAAACCGTGCGTTATTATCAACGCCAGGG
ACTGCTTCATGTTCCGTTGCTTAACAAAGAACTTGGAGCTGAAAAAATAAGGCGTTATGGTGACGATGATATAAGTCGCT
TAAAGTTTATCCTTTTAGCCAAAAAAGCAGGCTTTACTTTAAAAGAAATAAAAGAACTATTGGAGTTTGATGCTAAAAAT
GATCGAGAGCGCGTAAGAGATATGGCTGAAAGGCGTATTGAAAAACTTAATTTAAAAATTAATGAATTAACCGAAGCTCG
GAATAGACTTTCACTCTTAGTAACAAAATGTATAGAAACCAGCTCTTCACCTTGCCCCATACTTATGACCTTTGAGAAAA
GTTAA

Upstream 100 bases:

>100_bases
AAACTGCTTTTTTAATTGAAGTATGATTCATTTCTATCCCCTATGATTAATGGTCTATAAATAGTAATATAGAGTACGTA
CTATAGTACGGAGTCAAGTA

Downstream 100 bases:

>100_bases
ACCCATAAAAATAGAAAGCCATTAAATTATTGATAATTTCCAAAATTTCTTCATGAGAAGCTTTTGCTATTACGTTACTC
ACCAGCTGTCAATTTTCATC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MNNKKIGEFAKLCGVGIETVRYYQRQGLLHVPLLNKELGAEKIRRYGDDDISRLKFILLAKKAGFTLKEIKELLEFDAKN
DRERVRDMAERRIEKLNLKINELTEARNRLSLLVTKCIETSSSPCPILMTFEKS

Sequences:

>Translated_134_residues
MNNKKIGEFAKLCGVGIETVRYYQRQGLLHVPLLNKELGAEKIRRYGDDDISRLKFILLAKKAGFTLKEIKELLEFDAKN
DRERVRDMAERRIEKLNLKINELTEARNRLSLLVTKCIETSSSPCPILMTFEKS
>Mature_134_residues
MNNKKIGEFAKLCGVGIETVRYYQRQGLLHVPLLNKELGAEKIRRYGDDDISRLKFILLAKKAGFTLKEIKELLEFDAKN
DRERVRDMAERRIEKLNLKINELTEARNRLSLLVTKCIETSSSPCPILMTFEKS

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=135, Percent_Identity=31.1111111111111, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15528; Mature: 15528

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKKIGEFAKLCGVGIETVRYYQRQGLLHVPLLNKELGAEKIRRYGDDDISRLKFILLA
CCCCHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCHHCCHHHHHHCCCCHHHHHHHHHHH
KKAGFTLKEIKELLEFDAKNDRERVRDMAERRIEKLNLKINELTEARNRLSLLVTKCIET
HCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
SSSPCPILMTFEKS
CCCCCCEEEEECCC
>Mature Secondary Structure
MNNKKIGEFAKLCGVGIETVRYYQRQGLLHVPLLNKELGAEKIRRYGDDDISRLKFILLA
CCCCHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCHHCCHHHHHHCCCCHHHHHHHHHHH
KKAGFTLKEIKELLEFDAKNDRERVRDMAERRIEKLNLKINELTEARNRLSLLVTKCIET
HCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
SSSPCPILMTFEKS
CCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]