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The map label for this gene is ywbH

Identifier: 52787734

GI number: 52787734

Start: 3881201

End: 3881587

Strand: Direct

Name: ywbH

Synonym: BLi04057

Alternate gene names: 52787734

Gene position: 3881201-3881587 (Clockwise)

Preceding gene: 52787727

Following gene: 52787735

Centisome position: 91.91

GC content: 43.15

Gene sequence:

>387_bases
ATGAAAACATTCATTAAAGGATTAGGTCAGGTCGCTCTTTTGTTTTTATTCGCCCGTTTCATGAATCTGATTGTCGAGGT
TCTTCATATAAACATTCCCGGCAGCATTCTCGGGATTATCGTCATTTTTGCGCTTCTCCATTTCAAAATCATTAAGCTGG
AATGGATTGAAATCGGCGCGCTGTGGCTTCTCGCGGAGCTGCTTTTGTTCTTCGTCCCTTCAGCCGTCGGGATTATGAAC
TACGGAGATATTCTGGCTGAATTCGGCACAAGCATTATACTCGTTGTCCTCATCAGTACATTCGTCGTCATGGTGTCGAC
CGGAATGCTGACTCAATTGATTGCCAAAAGAAAGGAAAGAAAAAAAACATGCTCATCGGATGCTTAA

Upstream 100 bases:

>100_bases
CTTTTAACTATAGACAAAATGAATAATATATATTCTGTATATGTATTTTACCTATACTTGAAACTCATGTACACTCTTGT
TTAGAAAGGGGGATAATGAC

Downstream 100 bases:

>100_bases
GCCTGATCGCAACAGTTTTAATCTATTTGGGCGCAAAAGCGGTGTATTCACGCCATCCAAAGGTGTATGCGTCACCTTTA
TTGGTCACGCCGGTGATACT

Product: holin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MKTFIKGLGQVALLFLFARFMNLIVEVLHINIPGSILGIIVIFALLHFKIIKLEWIEIGALWLLAELLLFFVPSAVGIMN
YGDILAEFGTSIILVVLISTFVVMVSTGMLTQLIAKRKERKKTCSSDA

Sequences:

>Translated_128_residues
MKTFIKGLGQVALLFLFARFMNLIVEVLHINIPGSILGIIVIFALLHFKIIKLEWIEIGALWLLAELLLFFVPSAVGIMN
YGDILAEFGTSIILVVLISTFVVMVSTGMLTQLIAKRKERKKTCSSDA
>Mature_128_residues
MKTFIKGLGQVALLFLFARFMNLIVEVLHINIPGSILGIIVIFALLHFKIIKLEWIEIGALWLLAELLLFFVPSAVGIMN
YGDILAEFGTSIILVVLISTFVVMVSTGMLTQLIAKRKERKKTCSSDA

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily

Homologues:

Organism=Escherichia coli, GI1788463, Length=99, Percent_Identity=37.3737373737374, Blast_Score=63, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CIDA_BACLD (Q65DJ4)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_081135.1
- RefSeq:   YP_093563.1
- STRING:   Q65DJ4
- EnsemblBacteria:   EBBACT00000056576
- EnsemblBacteria:   EBBACT00000058479
- GeneID:   3029558
- GeneID:   3099304
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi04057
- KEGG:   bli:BL03941
- NMPDR:   fig|279010.5.peg.3178
- eggNOG:   COG1380
- GeneTree:   EBGT00050000000864
- HOGENOM:   HBG697118
- OMA:   LEWIEIG
- ProtClustDB:   PRK01658
- BioCyc:   BLIC279010-1:BLI04057-MONOMER
- BioCyc:   BLIC279010:BL03941-MONOMER
- GO:   GO:0019835
- HAMAP:   MF_01143
- InterPro:   IPR005538

Pfam domain/function: PF03788 LrgA

EC number: NA

Molecular weight: Translated: 14224; Mature: 14224

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x136984c0)-; HASH(0x1314c8ac)-; HASH(0x1379a714)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFIKGLGQVALLFLFARFMNLIVEVLHINIPGSILGIIVIFALLHFKIIKLEWIEIGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWLLAELLLFFVPSAVGIMNYGDILAEFGTSIILVVLISTFVVMVSTGMLTQLIAKRKER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKTCSSDA
HHCCCCCH
>Mature Secondary Structure
MKTFIKGLGQVALLFLFARFMNLIVEVLHINIPGSILGIIVIFALLHFKIIKLEWIEIGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWLLAELLLFFVPSAVGIMNYGDILAEFGTSIILVVLISTFVVMVSTGMLTQLIAKRKER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKTCSSDA
HHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA