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The map label for this gene is comA [H]

Identifier: 52787713

GI number: 52787713

Start: 3862564

End: 3863196

Strand: Reverse

Name: comA [H]

Synonym: BLi04036

Alternate gene names: 52787713

Gene position: 3863196-3862564 (Counterclockwise)

Preceding gene: 52787714

Following gene: 52787712

Centisome position: 91.49

GC content: 39.97

Gene sequence:

>633_bases
ATGATACGCGTGTTGTTAGTAGACGACTACAGGGTTCTGACATCCGGAATGAAGGAAATATTAAAAAAATATAATATGGA
TGTCATCGTTTGCCACGAAGGAAATGAAGCTCTCGACCTCTTAAAAAACCAAGAGGTACATATAGACGTTTTTCTTTATG
ATTTAAAAATGCCGGGGATGAACGGGTTGGAACTGTCTCTTAAAACGCTGGAAATCGAACCTCAATCCAAAATTATCATT
ATGTTTTCGGGAGATGAAATTCACTCATATTTTAATAAGTTGATCGAGGCCGGAGTTAAAGGGTTTATAGATAAATCGTA
TACAGACAGCATGATAGCTTCGAGTATTTTATTGTGTTTAAAAGGGGCTGTGTTATTTCCCGACGGCTTGCTGCAAAAAC
TGAGACTCGACTCCGATCTCTCGGTGGACGAGCATTTAACAGACACAGAACTGGATATTTTGCAGAAGGTGGCCAGCGGT
AAAACAAATAAAGAGATCGCAGCAGACCTGCAAATGTCGACGCGGAACGTAGAGTATCACTTGAGCAAAATCTATAAAAA
GCTCAAAGTAACGTCGCGGTACTGCGCAGTAAAAAAAGGGACGATGCTTAATTTGATCAAGCAGAAAGTATAG

Upstream 100 bases:

>100_bases
CAAAAAGGCACTAAAACCCGACATCATCCTTCAATTCTATTCATGGGGTTTTTATTGCGGTATTTGTTCGGAGGAAACTG
ATTTAAGGAGAGTGTTACTG

Downstream 100 bases:

>100_bases
ACAAAGTATATATTCGTTTTTCCCTGCAAAAGAGAGTCGATAGGCTCTCTTTTTCTTTTTCCTCCGAATAAATCCCGTAA
TAATGGCCCATTGATGCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: Competence protein A [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIRVLLVDDYRVLTSGMKEILKKYNMDVIVCHEGNEALDLLKNQEVHIDVFLYDLKMPGMNGLELSLKTLEIEPQSKIII
MFSGDEIHSYFNKLIEAGVKGFIDKSYTDSMIASSILLCLKGAVLFPDGLLQKLRLDSDLSVDEHLTDTELDILQKVASG
KTNKEIAADLQMSTRNVEYHLSKIYKKLKVTSRYCAVKKGTMLNLIKQKV

Sequences:

>Translated_210_residues
MIRVLLVDDYRVLTSGMKEILKKYNMDVIVCHEGNEALDLLKNQEVHIDVFLYDLKMPGMNGLELSLKTLEIEPQSKIII
MFSGDEIHSYFNKLIEAGVKGFIDKSYTDSMIASSILLCLKGAVLFPDGLLQKLRLDSDLSVDEHLTDTELDILQKVASG
KTNKEIAADLQMSTRNVEYHLSKIYKKLKVTSRYCAVKKGTMLNLIKQKV
>Mature_210_residues
MIRVLLVDDYRVLTSGMKEILKKYNMDVIVCHEGNEALDLLKNQEVHIDVFLYDLKMPGMNGLELSLKTLEIEPQSKIII
MFSGDEIHSYFNKLIEAGVKGFIDKSYTDSMIASSILLCLKGAVLFPDGLLQKLRLDSDLSVDEHLTDTELDILQKVASG
KTNKEIAADLQMSTRNVEYHLSKIYKKLKVTSRYCAVKKGTMLNLIKQKV

Specific function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, d

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=198, Percent_Identity=30.8080808080808, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786747, Length=194, Percent_Identity=27.319587628866, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1788712, Length=193, Percent_Identity=25.9067357512953, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788222, Length=197, Percent_Identity=26.9035532994924, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23788; Mature: 23788

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVLLVDDYRVLTSGMKEILKKYNMDVIVCHEGNEALDLLKNQEVHIDVFLYDLKMPGM
CEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCEEEEEEEEEEECCCC
NGLELSLKTLEIEPQSKIIIMFSGDEIHSYFNKLIEAGVKGFIDKSYTDSMIASSILLCL
CCCEEEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KGAVLFPDGLLQKLRLDSDLSVDEHLTDTELDILQKVASGKTNKEIAADLQMSTRNVEYH
CCCEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHH
LSKIYKKLKVTSRYCAVKKGTMLNLIKQKV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure
MIRVLLVDDYRVLTSGMKEILKKYNMDVIVCHEGNEALDLLKNQEVHIDVFLYDLKMPGM
CEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCEEEEEEEEEEECCCC
NGLELSLKTLEIEPQSKIIIMFSGDEIHSYFNKLIEAGVKGFIDKSYTDSMIASSILLCL
CCCEEEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KGAVLFPDGLLQKLRLDSDLSVDEHLTDTELDILQKVASGKTNKEIAADLQMSTRNVEYH
CCCEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHH
LSKIYKKLKVTSRYCAVKKGTMLNLIKQKV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2507523; 9274030; 9384377 [H]