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The map label for this gene is ung

Identifier: 52787689

GI number: 52787689

Start: 3835390

End: 3836067

Strand: Reverse

Name: ung

Synonym: BLi04012

Alternate gene names: 52787689

Gene position: 3836067-3835390 (Counterclockwise)

Preceding gene: 52787690

Following gene: 52787687

Centisome position: 90.85

GC content: 45.87

Gene sequence:

>678_bases
TTGAAACAGATTTTGAATGACAGCTGGTGGCAACAGCTGAAGGACGAGTTTGATAAGCCTTATTATCAAGAACTGAGGGA
AATGCTGAAAAGGGAGTATGCTGAACACACCGTATATCCTGAACCGAACGATATATACAATGCTTTGCATTATACTTCCT
ATGAAAATGTGAAAGTCGTAATTCTCGGCCAAGACCCGTATCACGGTCCGGGTCAGGCCCATGGCTTAAGTTTTTCCGTA
CAACCCGGCGTCAATCCACCGCCTTCTTTGAAAAATATTTTTATAGAATTGCAGAATGACATCGGCGCCGACATCCCGAA
TCACGGTTCTCTCGTCAGCTGGGCTAAGCAAGGCGTTCTGCTGCTGAACACCGTTTTGACCGTGAGACGGGGCCAGGCAA
ATTCGCATAAAGGGAAAGGCTGGGAACAGCTCACAGATAGTATAATAGATGTTTTAAACAAAAGAGACAAACCGGTCGTT
TTTATTCTCTGGGGCCGGCATGCCCAAATGAAAAAAGAACGAATCGATACATCCAAGCATTTTATTATCCAATCGCCGCA
TCCGAGCCCGTTCTCGGCTAGAAACGGGTTTTTCGGGAGCAGACCGTTTTCAAGAGCCAATCAGTATTTGGAACAAATCG
GGGATGAGCCGATTGACTGGTCCCTTCCGAATCTTTAA

Upstream 100 bases:

>100_bases
ATGAAAAAAAGGGAAGCGGAAAGCGAAATCGTCTGGGATGGAAAACCGGTTGCATCCAGGCTCACTGCTGCAAGACAATT
GAACTAAGGAGGCCTGAACA

Downstream 100 bases:

>100_bases
TCGCTAGAACCGCTAAAAAAGCGGTTCTTCGTTTGTCTGGCTCCTGTCTACCTGAGAAGTTTTTTGATGATCCGCAGCCC
GTTTTTCGATGAAGGATAAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKQILNDSWWQQLKDEFDKPYYQELREMLKREYAEHTVYPEPNDIYNALHYTSYENVKVVILGQDPYHGPGQAHGLSFSV
QPGVNPPPSLKNIFIELQNDIGADIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWEQLTDSIIDVLNKRDKPVV
FILWGRHAQMKKERIDTSKHFIIQSPHPSPFSARNGFFGSRPFSRANQYLEQIGDEPIDWSLPNL

Sequences:

>Translated_225_residues
MKQILNDSWWQQLKDEFDKPYYQELREMLKREYAEHTVYPEPNDIYNALHYTSYENVKVVILGQDPYHGPGQAHGLSFSV
QPGVNPPPSLKNIFIELQNDIGADIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWEQLTDSIIDVLNKRDKPVV
FILWGRHAQMKKERIDTSKHFIIQSPHPSPFSARNGFFGSRPFSRANQYLEQIGDEPIDWSLPNL
>Mature_225_residues
MKQILNDSWWQQLKDEFDKPYYQELREMLKREYAEHTVYPEPNDIYNALHYTSYENVKVVILGQDPYHGPGQAHGLSFSV
QPGVNPPPSLKNIFIELQNDIGADIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWEQLTDSIIDVLNKRDKPVV
FILWGRHAQMKKERIDTSKHFIIQSPHPSPFSARNGFFGSRPFSRANQYLEQIGDEPIDWSLPNL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=217, Percent_Identity=52.5345622119816, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI19718751, Length=217, Percent_Identity=52.5345622119816, Blast_Score=235, Evalue=2e-62,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=54.4186046511628, Blast_Score=240, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17556304, Length=225, Percent_Identity=46.6666666666667, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=43.4599156118143, Blast_Score=190, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_BACLD (Q65DN9)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_081087.1
- RefSeq:   YP_093518.1
- ProteinModelPortal:   Q65DN9
- SMR:   Q65DN9
- STRING:   Q65DN9
- EnsemblBacteria:   EBBACT00000054398
- EnsemblBacteria:   EBBACT00000058553
- GeneID:   3028711
- GeneID:   3101644
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi04012
- KEGG:   bli:BL03895
- NMPDR:   fig|279010.5.peg.2917
- eggNOG:   COG0692
- GeneTree:   EBGT00050000000847
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   BLIC279010-1:BLI04012-MONOMER
- BioCyc:   BLIC279010:BL03895-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25874; Mature: 25874

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQILNDSWWQQLKDEFDKPYYQELREMLKREYAEHTVYPEPNDIYNALHYTSYENVKVV
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEE
ILGQDPYHGPGQAHGLSFSVQPGVNPPPSLKNIFIELQNDIGADIPNHGSLVSWAKQGVL
EECCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHH
LLNTVLTVRRGQANSHKGKGWEQLTDSIIDVLNKRDKPVVFILWGRHAQMKKERIDTSKH
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCE
FIIQSPHPSPFSARNGFFGSRPFSRANQYLEQIGDEPIDWSLPNL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKQILNDSWWQQLKDEFDKPYYQELREMLKREYAEHTVYPEPNDIYNALHYTSYENVKVV
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEE
ILGQDPYHGPGQAHGLSFSVQPGVNPPPSLKNIFIELQNDIGADIPNHGSLVSWAKQGVL
EECCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHH
LLNTVLTVRRGQANSHKGKGWEQLTDSIIDVLNKRDKPVVFILWGRHAQMKKERIDTSKH
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCE
FIIQSPHPSPFSARNGFFGSRPFSRANQYLEQIGDEPIDWSLPNL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA