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The map label for this gene is fbaA [H]

Identifier: 52787638

GI number: 52787638

Start: 3785200

End: 3786057

Strand: Reverse

Name: fbaA [H]

Synonym: BLi03960

Alternate gene names: 52787638

Gene position: 3786057-3785200 (Counterclockwise)

Preceding gene: 52787639

Following gene: 52787637

Centisome position: 89.66

GC content: 45.8

Gene sequence:

>858_bases
ATGCCTTTAGTATCAATGACGGAAATGTTGAATAAAGCAAAAGAAAACGGATATGCTGTCGGACAATTTAACTTAAATAA
CCTTGAGTTCACTCAAGCGATTTTACAAGCCGCTGAAGAAGAGAAATCTCCTGTTATCCTCGGTGTATCAGAAGGTGCGG
GACGCTATATGGGCGGTTTTAAAACCGTTGTTGCAATGGTTAAAGCGCTGATGGAAGAATACAACGTAACAGTGCCTGTT
GCGATTCACTTAGACCACGGTTCAAGCTTTGAATCTTGTGCAAAAGCGATTCATGCGGGATTCACTTCCGTTATGATCGA
CGCTTCTCACCATCCTTTCGAGGAAAACGTTGCGACGACTTCAAAAGTTGTTGAGCTCGCTCATTTCCACGGCGTATCAG
TTGAAGCTGAGCTTGGAACTGTAGGCGGACAGGAAGACGACGTAATTGCAGATGGCGTCATCTACGCGGATCCTAAAGAG
TGCCAAGAGCTTGTTGAGCGCACAGGAATCGACTGCCTTGCTCCTGCATTAGGTTCTGTTCACGGTCCTTACAAAGGCGA
ACCAAACCTTGGATTTAAAGAAATGGAAGAAATCGGAAATACAACTGGTCTTCCGCTCGTACTTCACGGCGGTACAGGCA
TTCCGACTGCCGACATTAAGAAAGCTATTTCTTTAGGTACGGCAAAAATCAACGTCAACACTGAAAACCAAATCGCTTCC
GCGAAAGCTGTTCGCGAAACGCTGGCTGCGAAGCCTGAAGAGTATGATCCGCGCAAATACCTCGGACCTGCACGCGAAGC
TATCAAAGAAACAGTTATCGGCAAAATGCGCGAATTTGGTTCTTCAAACAAAGCATAA

Upstream 100 bases:

>100_bases
CAAAACATTTTACATATGGCGGATTTTTCTGGTCATGCTAGGTAGGTGTGGAGGCTTTTTTCGCAAAAGCAAATCAGGCT
ACATAAGGAGGACTTTCGAC

Downstream 100 bases:

>100_bases
TGACGATTGGAAAAGCATCTGTTTTCCCGCAAAGCCGGGGAAACAGGATGTTTTTCTGGTGTTTTAGAGGGAAGTGCTGT
TAACACATGCCATGTGACGG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPLVSMTEMLNKAKENGYAVGQFNLNNLEFTQAILQAAEEEKSPVILGVSEGAGRYMGGFKTVVAMVKALMEEYNVTVPV
AIHLDHGSSFESCAKAIHAGFTSVMIDASHHPFEENVATTSKVVELAHFHGVSVEAELGTVGGQEDDVIADGVIYADPKE
CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGNTTGLPLVLHGGTGIPTADIKKAISLGTAKINVNTENQIAS
AKAVRETLAAKPEEYDPRKYLGPAREAIKETVIGKMREFGSSNKA

Sequences:

>Translated_285_residues
MPLVSMTEMLNKAKENGYAVGQFNLNNLEFTQAILQAAEEEKSPVILGVSEGAGRYMGGFKTVVAMVKALMEEYNVTVPV
AIHLDHGSSFESCAKAIHAGFTSVMIDASHHPFEENVATTSKVVELAHFHGVSVEAELGTVGGQEDDVIADGVIYADPKE
CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGNTTGLPLVLHGGTGIPTADIKKAISLGTAKINVNTENQIAS
AKAVRETLAAKPEEYDPRKYLGPAREAIKETVIGKMREFGSSNKA
>Mature_284_residues
PLVSMTEMLNKAKENGYAVGQFNLNNLEFTQAILQAAEEEKSPVILGVSEGAGRYMGGFKTVVAMVKALMEEYNVTVPVA
IHLDHGSSFESCAKAIHAGFTSVMIDASHHPFEENVATTSKVVELAHFHGVSVEAELGTVGGQEDDVIADGVIYADPKEC
QELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGNTTGLPLVLHGGTGIPTADIKKAISLGTAKINVNTENQIASA
KAVRETLAAKPEEYDPRKYLGPAREAIKETVIGKMREFGSSNKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=287, Percent_Identity=42.1602787456446, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1789526, Length=286, Percent_Identity=41.6083916083916, Blast_Score=227, Evalue=7e-61,
Organism=Escherichia coli, GI1788072, Length=279, Percent_Identity=41.5770609318996, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789293, Length=326, Percent_Identity=27.6073619631902, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322790, Length=338, Percent_Identity=24.2603550295858, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30384; Mature: 30253

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMTEMLNKAKENGYAVGQFNLNNLEFTQAILQAAEEEKSPVILGVSEGAGRYMGGF
CCCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
KTVVAMVKALMEEYNVTVPVAIHLDHGSSFESCAKAIHAGFTSVMIDASHHPFEENVATT
HHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCHHHEEEECCCCCCHHHHHHH
SKVVELAHFHGVSVEAELGTVGGQEDDVIADGVIYADPKECQELVERTGIDCLAPALGSV
HHHHHHHHHCCCEEEEECCCCCCCCCCEEECCEEECCHHHHHHHHHHCCCHHHHHHHHCC
HGPYKGEPNLGFKEMEEIGNTTGLPLVLHGGTGIPTADIKKAISLGTAKINVNTENQIAS
CCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCHHHHHH
AKAVRETLAAKPEEYDPRKYLGPAREAIKETVIGKMREFGSSNKA
HHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLVSMTEMLNKAKENGYAVGQFNLNNLEFTQAILQAAEEEKSPVILGVSEGAGRYMGGF
CCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
KTVVAMVKALMEEYNVTVPVAIHLDHGSSFESCAKAIHAGFTSVMIDASHHPFEENVATT
HHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCHHHEEEECCCCCCHHHHHHH
SKVVELAHFHGVSVEAELGTVGGQEDDVIADGVIYADPKECQELVERTGIDCLAPALGSV
HHHHHHHHHCCCEEEEECCCCCCCCCCEEECCEEECCHHHHHHHHHHCCCHHHHHHHHCC
HGPYKGEPNLGFKEMEEIGNTTGLPLVLHGGTGIPTADIKKAISLGTAKINVNTENQIAS
CCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCHHHHHH
AKAVRETLAAKPEEYDPRKYLGPAREAIKETVIGKMREFGSSNKA
HHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]