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The map label for this gene is hsrA [H]

Identifier: 52787574

GI number: 52787574

Start: 3716473

End: 3717906

Strand: Reverse

Name: hsrA [H]

Synonym: BLi03896

Alternate gene names: 52787574

Gene position: 3717906-3716473 (Counterclockwise)

Preceding gene: 52787575

Following gene: 52787572

Centisome position: 88.05

GC content: 53.97

Gene sequence:

>1434_bases
ATGAATAGAAGGCCGTTCAATCAAAGGACGGTTGTCAGCATTGTATATGTAACAGCCATGTTTATGGCTGCGATGGATGC
GAGTGTCATCAACATGGCATTGCCTGCCATCATGACCGAATTTCAAACATTGCCGTCTGCTGCAGGCACAGTTAACATCG
GATACTTAGTCAGCTTGGCGGTCTGTCTTCCCGCAGCCGGCTGGCTTGGGGACCGCTTTGGGACAAAGCGTGTTTTCCTA
GCCGCGCTTTCGATATTTACAGCTGCATCCGCCTTATGCGGAATCGCTGACAATCTGGCGGCGTTAAACGCATTTCGCGT
GATCCAGGGGGCCGGCGGCGGGTTGATTACGCCGGTGGGAATGGCGATCTTGTTCAGGACGTTTCCTCCGCATGAACGGG
CCAAAATTTCGAGAGTCCTCGTTCTTCCAATTGCCGTCGCGCCTGCGGTTGGGCCGATCATCAGCGGGTTTCTGACAGAT
CAGCTGTCATGGCGCTGGATTTTTTACATTAATATTCCGATCGGAATGATCATTCTGCTGTTTGGCCTGTTGTATCTTCA
TGAACATTTGGAGCCGGAAGCGGGCAGATTTGATTGGCTTGGATTCCTTTTGGCGGCGCCGGGAATGGCGTTGGCGGTTT
TTGCACTCAGCCAGGGGCCTGCGCGTGGATTCGGCTCTCCGGATGTGCTTGCAGCAGGGGCCGGGGGAATGATGCTCCTC
GCAATCCTCGTTTTTGTCGAACTGAAGGCTGAGCATCCGTTGATTGAACTTCGCTTATTGAAGGACCGGGTTTTTGGAAT
GATGAGCGTCATTTCGCTTCTGACAGCAGGCGGACTGCTTGGCATGCTCTATATATTTCCGCTGTTGTGTCAGGAAGCAC
TCGGCTACTCTGCGACAGATACTGCGCTGATTACGTTTCCCGAAGCATTAGGCTTGATGCTGGCGTCCCAGCTGATGCCG
AGGTCGTTGGCAAAGCTTGGCCCGAGGCGGGTCATTTCCGTTGCGCTGTTAGGCGCTGCTGTGCTGTTTGGGCTGCTGAG
CCTGACCGGATATGGGTCAAATCTTTGGCTTCTCAGGCTGCTGCTGTTTTTAGCGGGCTTTTTCTTGGGGCACGCGGTTG
GTGCGGCGCAGGTTGTTTGTTTTGCCAACATTTCATCATCCTCAATGGGCCGGGCAACAACGCTGTTTAATGTGCAAAAC
CGGCTCGGATCTGCCTTTGGAGTTGCTGTCATGTCGTGCGTCCTTGCTGTGCTCAGCCAGCCCAGCGCAGGCATAGAGCC
TGATTTATCAGCTTACCGGACAGCTTTGCTCTGTGCAGCCGGTTTCCTCATGGCTGCGCTTTTCATCGCACTCAAGCTCA
AGGACGCTGACACAGGCCGTCAAATGGACAAGCATGCTTCAGCACCCAAAGGTGCGGCAGCTTCTGGTGAGTAA

Upstream 100 bases:

>100_bases
AAGCGAGCCGCAGCGCCTGTATCGACTATATCAGCTCGAATTGGACCGATCTCTCGCCGAACAGCATCAAGCTGGTTGCA
GAAGTACACGGCGGTCAGCA

Downstream 100 bases:

>100_bases
AACAAAAATCCTCCCGTTTCCGGGAGGATTTTTTTAACAGCATGAATTGTGCGCTATAAAATCGGCGACAGCAGGATCGA
AATGGCTTCTTTGAAGCGGA

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNRRPFNQRTVVSIVYVTAMFMAAMDASVINMALPAIMTEFQTLPSAAGTVNIGYLVSLAVCLPAAGWLGDRFGTKRVFL
AALSIFTAASALCGIADNLAALNAFRVIQGAGGGLITPVGMAILFRTFPPHERAKISRVLVLPIAVAPAVGPIISGFLTD
QLSWRWIFYINIPIGMIILLFGLLYLHEHLEPEAGRFDWLGFLLAAPGMALAVFALSQGPARGFGSPDVLAAGAGGMMLL
AILVFVELKAEHPLIELRLLKDRVFGMMSVISLLTAGGLLGMLYIFPLLCQEALGYSATDTALITFPEALGLMLASQLMP
RSLAKLGPRRVISVALLGAAVLFGLLSLTGYGSNLWLLRLLLFLAGFFLGHAVGAAQVVCFANISSSSMGRATTLFNVQN
RLGSAFGVAVMSCVLAVLSQPSAGIEPDLSAYRTALLCAAGFLMAALFIALKLKDADTGRQMDKHASAPKGAAASGE

Sequences:

>Translated_477_residues
MNRRPFNQRTVVSIVYVTAMFMAAMDASVINMALPAIMTEFQTLPSAAGTVNIGYLVSLAVCLPAAGWLGDRFGTKRVFL
AALSIFTAASALCGIADNLAALNAFRVIQGAGGGLITPVGMAILFRTFPPHERAKISRVLVLPIAVAPAVGPIISGFLTD
QLSWRWIFYINIPIGMIILLFGLLYLHEHLEPEAGRFDWLGFLLAAPGMALAVFALSQGPARGFGSPDVLAAGAGGMMLL
AILVFVELKAEHPLIELRLLKDRVFGMMSVISLLTAGGLLGMLYIFPLLCQEALGYSATDTALITFPEALGLMLASQLMP
RSLAKLGPRRVISVALLGAAVLFGLLSLTGYGSNLWLLRLLLFLAGFFLGHAVGAAQVVCFANISSSSMGRATTLFNVQN
RLGSAFGVAVMSCVLAVLSQPSAGIEPDLSAYRTALLCAAGFLMAALFIALKLKDADTGRQMDKHASAPKGAAASGE
>Mature_477_residues
MNRRPFNQRTVVSIVYVTAMFMAAMDASVINMALPAIMTEFQTLPSAAGTVNIGYLVSLAVCLPAAGWLGDRFGTKRVFL
AALSIFTAASALCGIADNLAALNAFRVIQGAGGGLITPVGMAILFRTFPPHERAKISRVLVLPIAVAPAVGPIISGFLTD
QLSWRWIFYINIPIGMIILLFGLLYLHEHLEPEAGRFDWLGFLLAAPGMALAVFALSQGPARGFGSPDVLAAGAGGMMLL
AILVFVELKAEHPLIELRLLKDRVFGMMSVISLLTAGGLLGMLYIFPLLCQEALGYSATDTALITFPEALGLMLASQLMP
RSLAKLGPRRVISVALLGAAVLFGLLSLTGYGSNLWLLRLLLFLAGFFLGHAVGAAQVVCFANISSSSMGRATTLFNVQN
RLGSAFGVAVMSCVLAVLSQPSAGIEPDLSAYRTALLCAAGFLMAALFIALKLKDADTGRQMDKHASAPKGAAASGE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=485, Percent_Identity=31.340206185567, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789042, Length=420, Percent_Identity=26.9047619047619, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788392, Length=437, Percent_Identity=27.9176201372998, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788710, Length=410, Percent_Identity=28.5365853658537, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081983, Length=316, Percent_Identity=29.1139240506329, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6325455, Length=131, Percent_Identity=33.587786259542, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=171, Percent_Identity=29.8245614035088, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=260, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=29.3333333333333, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50266; Mature: 50266

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRPFNQRTVVSIVYVTAMFMAAMDASVINMALPAIMTEFQTLPSAAGTVNIGYLVSLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VCLPAAGWLGDRFGTKRVFLAALSIFTAASALCGIADNLAALNAFRVIQGAGGGLITPVG
HHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MAILFRTFPPHERAKISRVLVLPIAVAPAVGPIISGFLTDQLSWRWIFYINIPIGMIILL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHH
FGLLYLHEHLEPEAGRFDWLGFLLAAPGMALAVFALSQGPARGFGSPDVLAAGAGGMMLL
HHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHH
AILVFVELKAEHPLIELRLLKDRVFGMMSVISLLTAGGLLGMLYIFPLLCQEALGYSATD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TALITFPEALGLMLASQLMPRSLAKLGPRRVISVALLGAAVLFGLLSLTGYGSNLWLLRL
CEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLFLAGFFLGHAVGAAQVVCFANISSSSMGRATTLFNVQNRLGSAFGVAVMSCVLAVLSQ
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
PSAGIEPDLSAYRTALLCAAGFLMAALFIALKLKDADTGRQMDKHASAPKGAAASGE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNRRPFNQRTVVSIVYVTAMFMAAMDASVINMALPAIMTEFQTLPSAAGTVNIGYLVSLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VCLPAAGWLGDRFGTKRVFLAALSIFTAASALCGIADNLAALNAFRVIQGAGGGLITPVG
HHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MAILFRTFPPHERAKISRVLVLPIAVAPAVGPIISGFLTDQLSWRWIFYINIPIGMIILL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHH
FGLLYLHEHLEPEAGRFDWLGFLLAAPGMALAVFALSQGPARGFGSPDVLAAGAGGMMLL
HHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHH
AILVFVELKAEHPLIELRLLKDRVFGMMSVISLLTAGGLLGMLYIFPLLCQEALGYSATD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TALITFPEALGLMLASQLMPRSLAKLGPRRVISVALLGAAVLFGLLSLTGYGSNLWLLRL
CEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLFLAGFFLGHAVGAAQVVCFANISSSSMGRATTLFNVQNRLGSAFGVAVMSCVLAVLSQ
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
PSAGIEPDLSAYRTALLCAAGFLMAALFIALKLKDADTGRQMDKHASAPKGAAASGE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]