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The map label for this gene is yvbW [H]

Identifier: 52787353

GI number: 52787353

Start: 3494964

End: 3496331

Strand: Reverse

Name: yvbW [H]

Synonym: BLi03669

Alternate gene names: 52787353

Gene position: 3496331-3494964 (Counterclockwise)

Preceding gene: 52787355

Following gene: 52787352

Centisome position: 82.8

GC content: 48.46

Gene sequence:

>1368_bases
ATGGAGAAAGACATGCAGAAGCTCGAGCGCACGATGACATCGCGGCATATTATGATGATGGCATTGGGCGGAGCGATTGG
GGCAGGATTATTTAAAGGAAGCAGCAAAGCGATCGATTTGGCGGGGCCTTCGGTCATGATCCCCTACTTGATCGGCGGCG
TGATTTTGCTGTTTATTATGCAGGGGCTGGCCGAGATGGCTGTCCGAAACAGCGAAGCCAGAACATTCAGGGATCTGGTT
CAATCGATATTAGGGCCGTATGCCGCTTATTTTTTGGACTGGATATACTGGAAAATGTGGGTTCTCAATATTGCGGCTGA
GGCTGTTGTCGCCGCGATGTTTTTGCAGTACTGGCTGCCGGGGCTGCCGATTTGGGTGCTGGCGCTGTTCGTTTCACTCG
TCATTACGAGCGTGAATTTGCTTTCTGTCAAAAGCTTTGCCGAGACGGAATACTGGCTTGCTCTCATTAAAATCACAGTG
ATTGTCGTCTTTATTATATCCGGATTTATCTTGTTATTTTTCTCTTTTGGACAACATTCGGCTGTCGGCTTTACTCATTT
GACAGACCATGGCGGCTTCTTCCCGAATGGCGCCGGAGGGCTGATTACAGCCATGCTTGTCGTGATCTATTCCTACGGCG
GAACGGAAATTATCGGGGTGACCCTGGCGGAAACCAAAAATCCTGAGAAGGTTGTGCCTAAAGCCGTGCGGGGAACGTTA
ACGCGCATTATTGCTTTTTATCTTCTGCCGTTTTTCGTGATCGTCAGCTTGATTCCATGGAATCAAGTGAACGGGGTGTC
GGAGAGTCCCTTTGTCATGGTCTTTAAGATGATCGGCGTTCCCGGAGCGGATCATTTGATGAATGCGGTCATTTTACTGG
CGGTCATTTCTTCTATGAACTCAGGGCTTTACGGCGCCTCCCGTATTTTGTATACACAGGCGTCAGACGGAAGAATGCCG
AAAATCTTTTCGAGGCTTTCTGCGAGAAAGGTGCCGGTTTATTCGATTCTATTATGCACTTCGTTCTTATACTTGGGCGT
ATTGTTTTCACTATTTGCCGGCAGCCAAACGTTTGAATATTTGATGGGGTCTCTCGGCTATACCGTCCTTGTGATCTGGA
TGCTGATTGCCGCCGCCCATTTAAAATCGAGGAAACGGAATCAAACAGCTGGAAACGGCTACTATGTCAAATGGTTCCCT
TATACGACTTGGGTGGCAATCATTTCGCTGACAGCCATACTGATCGGTGTCATCCTGACCACGTCGATTGTCATTACATT
GGTGACGGCGGGGATCTATTTGCTCATTAGCGCTGCTTATTTCTTTAAAGGAAGAAACCAGACAGCCGGCCAAACGGCCG
CTTCTTAA

Upstream 100 bases:

>100_bases
AGTGGTACCGCGGTAAGCTTCAAAGCTCATCGTCTCTTTATCTTCAAATTGAAGAGGGAGACGGTGAGCTTTTTTATTTT
AATAGAGGAAGTGAACATAG

Downstream 100 bases:

>100_bases
AAAAGGGCTTGCCTCCCAGCGGAGGCAAGCTTTTTATACATTAGTTCGATTTTTTTCGAACTAATTTCTTTTATTCACCG
GGACGATTATGTTATCGTCT

Product: YvbW

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MEKDMQKLERTMTSRHIMMMALGGAIGAGLFKGSSKAIDLAGPSVMIPYLIGGVILLFIMQGLAEMAVRNSEARTFRDLV
QSILGPYAAYFLDWIYWKMWVLNIAAEAVVAAMFLQYWLPGLPIWVLALFVSLVITSVNLLSVKSFAETEYWLALIKITV
IVVFIISGFILLFFSFGQHSAVGFTHLTDHGGFFPNGAGGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRGTL
TRIIAFYLLPFFVIVSLIPWNQVNGVSESPFVMVFKMIGVPGADHLMNAVILLAVISSMNSGLYGASRILYTQASDGRMP
KIFSRLSARKVPVYSILLCTSFLYLGVLFSLFAGSQTFEYLMGSLGYTVLVIWMLIAAAHLKSRKRNQTAGNGYYVKWFP
YTTWVAIISLTAILIGVILTTSIVITLVTAGIYLLISAAYFFKGRNQTAGQTAAS

Sequences:

>Translated_455_residues
MEKDMQKLERTMTSRHIMMMALGGAIGAGLFKGSSKAIDLAGPSVMIPYLIGGVILLFIMQGLAEMAVRNSEARTFRDLV
QSILGPYAAYFLDWIYWKMWVLNIAAEAVVAAMFLQYWLPGLPIWVLALFVSLVITSVNLLSVKSFAETEYWLALIKITV
IVVFIISGFILLFFSFGQHSAVGFTHLTDHGGFFPNGAGGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRGTL
TRIIAFYLLPFFVIVSLIPWNQVNGVSESPFVMVFKMIGVPGADHLMNAVILLAVISSMNSGLYGASRILYTQASDGRMP
KIFSRLSARKVPVYSILLCTSFLYLGVLFSLFAGSQTFEYLMGSLGYTVLVIWMLIAAAHLKSRKRNQTAGNGYYVKWFP
YTTWVAIISLTAILIGVILTTSIVITLVTAGIYLLISAAYFFKGRNQTAGQTAAS
>Mature_455_residues
MEKDMQKLERTMTSRHIMMMALGGAIGAGLFKGSSKAIDLAGPSVMIPYLIGGVILLFIMQGLAEMAVRNSEARTFRDLV
QSILGPYAAYFLDWIYWKMWVLNIAAEAVVAAMFLQYWLPGLPIWVLALFVSLVITSVNLLSVKSFAETEYWLALIKITV
IVVFIISGFILLFFSFGQHSAVGFTHLTDHGGFFPNGAGGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRGTL
TRIIAFYLLPFFVIVSLIPWNQVNGVSESPFVMVFKMIGVPGADHLMNAVILLAVISSMNSGLYGASRILYTQASDGRMP
KIFSRLSARKVPVYSILLCTSFLYLGVLFSLFAGSQTFEYLMGSLGYTVLVIWMLIAAAHLKSRKRNQTAGNGYYVKWFP
YTTWVAIISLTAILIGVILTTSIVITLVTAGIYLLISAAYFFKGRNQTAGQTAAS

Specific function: Transporter For Gaba. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=359, Percent_Identity=22.8412256267409, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI110347453, Length=352, Percent_Identity=23.2954545454545, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=37.122969837587, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=35.0332594235033, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1790653, Length=386, Percent_Identity=38.3419689119171, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1786789, Length=410, Percent_Identity=38.2926829268293, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI48994972, Length=453, Percent_Identity=33.5540838852097, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87081708, Length=462, Percent_Identity=32.034632034632, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1786602, Length=385, Percent_Identity=37.4025974025974, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788480, Length=390, Percent_Identity=34.8717948717949, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=32.2815533980583, Blast_Score=238, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17540018, Length=354, Percent_Identity=22.5988700564972, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=363, Percent_Identity=21.2121212121212, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=401, Percent_Identity=31.6708229426434, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=399, Percent_Identity=30.8270676691729, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=31.7380352644836, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=401, Percent_Identity=30.1745635910224, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=459, Percent_Identity=27.2331154684096, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=458, Percent_Identity=29.2576419213974, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324059, Length=405, Percent_Identity=30.1234567901235, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=415, Percent_Identity=28.9156626506024, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=410, Percent_Identity=27.0731707317073, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=415, Percent_Identity=28.433734939759, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=410, Percent_Identity=28.0487804878049, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322892, Length=400, Percent_Identity=29, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=403, Percent_Identity=27.0471464019851, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=421, Percent_Identity=27.0783847980998, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=401, Percent_Identity=27.431421446384, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324981, Length=394, Percent_Identity=26.3959390862944, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319608, Length=356, Percent_Identity=25.2808988764045, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=495, Percent_Identity=22.8282828282828, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24667468, Length=352, Percent_Identity=23.2954545454545, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666159, Length=460, Percent_Identity=20.6521739130435, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221512776, Length=460, Percent_Identity=20.6521739130435, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49867; Mature: 49867

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1 ; PS50049 TNF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKDMQKLERTMTSRHIMMMALGGAIGAGLFKGSSKAIDLAGPSVMIPYLIGGVILLFIM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHH
QGLAEMAVRNSEARTFRDLVQSILGPYAAYFLDWIYWKMWVLNIAAEAVVAAMFLQYWLP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLPIWVLALFVSLVITSVNLLSVKSFAETEYWLALIKITVIVVFIISGFILLFFSFGQHS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVGFTHLTDHGGFFPNGAGGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRGTL
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHH
TRIIAFYLLPFFVIVSLIPWNQVNGVSESPFVMVFKMIGVPGADHLMNAVILLAVISSMN
HHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
SGLYGASRILYTQASDGRMPKIFSRLSARKVPVYSILLCTSFLYLGVLFSLFAGSQTFEY
CCCCCCHHEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMGSLGYTVLVIWMLIAAAHLKSRKRNQTAGNGYYVKWFPYTTWVAIISLTAILIGVILT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
TSIVITLVTAGIYLLISAAYFFKGRNQTAGQTAAS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEKDMQKLERTMTSRHIMMMALGGAIGAGLFKGSSKAIDLAGPSVMIPYLIGGVILLFIM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHH
QGLAEMAVRNSEARTFRDLVQSILGPYAAYFLDWIYWKMWVLNIAAEAVVAAMFLQYWLP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLPIWVLALFVSLVITSVNLLSVKSFAETEYWLALIKITVIVVFIISGFILLFFSFGQHS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVGFTHLTDHGGFFPNGAGGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRGTL
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHH
TRIIAFYLLPFFVIVSLIPWNQVNGVSESPFVMVFKMIGVPGADHLMNAVILLAVISSMN
HHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
SGLYGASRILYTQASDGRMPKIFSRLSARKVPVYSILLCTSFLYLGVLFSLFAGSQTFEY
CCCCCCHHEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMGSLGYTVLVIWMLIAAAHLKSRKRNQTAGNGYYVKWFPYTTWVAIISLTAILIGVILT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
TSIVITLVTAGIYLLISAAYFFKGRNQTAGQTAAS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]