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The map label for this gene is yvgW [H]

Identifier: 52787229

GI number: 52787229

Start: 3379965

End: 3382076

Strand: Reverse

Name: yvgW [H]

Synonym: BLi03539

Alternate gene names: 52787229

Gene position: 3382076-3379965 (Counterclockwise)

Preceding gene: 52787243

Following gene: 52787228

Centisome position: 80.09

GC content: 50.76

Gene sequence:

>2112_bases
ATGGAAAAGGTGAAACAGGAGTACACGCTAAACGGCCTTGACTGCAGCAATTGCGCACAAAAAATTGAGCATGAGATAGC
CGGTATGAAGGGGATTGAAGCGTGTTCGGTCAATTTTGCAACAAGCACGCTGACTGTCCAAGTCGACCAAAACAGCGGCG
AAGACATTTCTTTAATAATAAAGAAAAAAGTAACCGAGATCGAACCGCACGTCAACGCGACGCTGAAGGAAGGGACAAAA
CAGGCCCCACCAGAAAGCGACGGACGGTTTAAAAAAACGGTTGCAAGGCTTGCTGCAGGAACCGTTCTCGGTGCGGCGGG
CTTTCTGCTTCCCGGCGGCACCGCAGCCGAGTGGCTTCTTTTTTTCCTAGCTTACCTCATCATCGGCGGCGATGTCGTAT
TAAGGGCCGTCAAAAACATCTTTCGCGGCCGGGTTTTTGATGAGCACTTTTTAATGACGATCGCCACTCTGGGGGCATTT
ATTATTCAGCAGTATCCCGAGGGTGTGGCGGTTATGCTGTTCTATCAAATAGGCGAGCTGTTCCAGGGAGCCGCGGTCAC
CCGCTCCCGGAAGTCGATCAGCGATTTGATGGACATCCGTCCCGACTATGCCAATCTTCAAACCGAAGGCGGAACGGTCA
AAGTGTCTCCCGATGAGGTCAAAGCCGGCGATATCATCATCGTCAAGCCGGGAGAGAAAGTGCCGCTTGACGGCAAAGTG
CGGGCAGGCAAATCGCTTGTCGATACGTCCGCATTAACCGGAGAATCCGTTCCGAGAGAAGCCGCTCCCGGAACAGAGGT
GCTGAGCGGATTTGTCAACAAAAACGGCGTGCTTGAAGTGGAAGTGGACAAAGAATACAGTGAATCAACCGTTTCAAAGA
TTCTTGACCTCGTTCAGAATGCCAGCAGCAGAAAAGCGAAAACAGAGAATTTTATCACCAAATTCGCCAAGTATTACACG
CCTTTCGTTGTGATAATCGCGCTTCTTCTCGCTTTTGTCCCGCCGCTGATTATTTCAGGCGCCCTGCTGTCAGATTGGGT
GTACCGCGCCCTTGTCTTTTTGGTCATTTCTTGTCCGTGCGCGCTCGTCGTTTCCATTCCGCTCGGCTTTTTCGGCGGCA
TCGGAGCGGCGTCAAAAGCAGGTATACTCGTGAAAGGCGGCAATTATTTAGAAGCGCTGAATGATGTCAAATACGCCGTT
TTTGACAAAACAGGCACTTTAACAAAAGGGGAATTTGCCGTTGTCAAGCTGTCGCCTGCAAGCCATGTCAAAGAAGATGA
ACTGCTTGAATATGCGGCGCTTGCCGAACATTTCTCCGGCCATCCGATCGCCGAGTCGATCCGTGAAGCATACGGGAAGG
AAGTACAAGCGGACCGCATCAAAGATTACAGCGAGACGGCCGGCTTCGGCGTCAGAGCGGTTGTAGACGGAGCCGTCATT
TTAGCCGGGAATGCCAAGCTTATGAAGAAAGCCGGCATACAGTATCAAAAGGAAAGTGAAATCGGAACTGTTGTTTATGT
AGCCGCCGGCGATACGTTTATCGGCTCGATTGTCATCGCTGACGAAATCAAAGAGGATGCCAAGCGTGCGATCTCCGCTT
TGAAAAAAGCGGGTATTAAAAAAACGGTGATGCTGACGGGCGACGCGAAAGACACCGGTGAGGCGGTCGGCGAACAGCTG
TCCATTGATGAAGTGCATGCGGAGCTACTTCCGCAGCACAAGGTGGACCGTATTGAAACATTAGATAAGCAAAAACTTCC
AAAAGAAAAGCTGCTTTTTGCAGGAGACGGCATCAACGATACGCCGGTCTTGGCGAGAGCGGATATCGGGGTTGCCATGG
GAGGCCTCGGTTCTGATGCGGCAGTCGAAGCGGCTGATATTGTGATCATGACGGATCAGCCTTCAAAAATTGCGGAAGCC
ATCAGCATTGCCAAGCGGACGAGGACGATTGTCTGGCAGAATATTATTTTTGCACTCGGCGTTAAAGGAGTTTTTCTCAT
CCTGGGTGCTTTTGGCATCGCGACGATGTGGGAAGCCGTCTTTTCAGACGTCGGTGTTACCCTTCTGGCTGTTTTAAATG
CGATGAGGGTATTAAAAGTGAAAGAAATGTAA

Upstream 100 bases:

>100_bases
ACACATTTTTCGGATGAAGCATATAATAAGGGTAGATAATATATGCGTATATGCTCATATATAAAATAAAGCCCGGCGCT
GAAAAAGAAAGGTGAGAGAG

Downstream 100 bases:

>100_bases
CTTTTTTACCACCTAATGAACTGGAAATTCCTTTTTTAGCATCTTCACGAATGCGGCTTGTCTTGTTAAAATGAAAGAGG
TTATCAAACTGGCATACTAA

Product: YvgW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 703

Protein sequence:

>703_residues
MEKVKQEYTLNGLDCSNCAQKIEHEIAGMKGIEACSVNFATSTLTVQVDQNSGEDISLIIKKKVTEIEPHVNATLKEGTK
QAPPESDGRFKKTVARLAAGTVLGAAGFLLPGGTAAEWLLFFLAYLIIGGDVVLRAVKNIFRGRVFDEHFLMTIATLGAF
IIQQYPEGVAVMLFYQIGELFQGAAVTRSRKSISDLMDIRPDYANLQTEGGTVKVSPDEVKAGDIIIVKPGEKVPLDGKV
RAGKSLVDTSALTGESVPREAAPGTEVLSGFVNKNGVLEVEVDKEYSESTVSKILDLVQNASSRKAKTENFITKFAKYYT
PFVVIIALLLAFVPPLIISGALLSDWVYRALVFLVISCPCALVVSIPLGFFGGIGAASKAGILVKGGNYLEALNDVKYAV
FDKTGTLTKGEFAVVKLSPASHVKEDELLEYAALAEHFSGHPIAESIREAYGKEVQADRIKDYSETAGFGVRAVVDGAVI
LAGNAKLMKKAGIQYQKESEIGTVVYVAAGDTFIGSIVIADEIKEDAKRAISALKKAGIKKTVMLTGDAKDTGEAVGEQL
SIDEVHAELLPQHKVDRIETLDKQKLPKEKLLFAGDGINDTPVLARADIGVAMGGLGSDAAVEAADIVIMTDQPSKIAEA
ISIAKRTRTIVWQNIIFALGVKGVFLILGAFGIATMWEAVFSDVGVTLLAVLNAMRVLKVKEM

Sequences:

>Translated_703_residues
MEKVKQEYTLNGLDCSNCAQKIEHEIAGMKGIEACSVNFATSTLTVQVDQNSGEDISLIIKKKVTEIEPHVNATLKEGTK
QAPPESDGRFKKTVARLAAGTVLGAAGFLLPGGTAAEWLLFFLAYLIIGGDVVLRAVKNIFRGRVFDEHFLMTIATLGAF
IIQQYPEGVAVMLFYQIGELFQGAAVTRSRKSISDLMDIRPDYANLQTEGGTVKVSPDEVKAGDIIIVKPGEKVPLDGKV
RAGKSLVDTSALTGESVPREAAPGTEVLSGFVNKNGVLEVEVDKEYSESTVSKILDLVQNASSRKAKTENFITKFAKYYT
PFVVIIALLLAFVPPLIISGALLSDWVYRALVFLVISCPCALVVSIPLGFFGGIGAASKAGILVKGGNYLEALNDVKYAV
FDKTGTLTKGEFAVVKLSPASHVKEDELLEYAALAEHFSGHPIAESIREAYGKEVQADRIKDYSETAGFGVRAVVDGAVI
LAGNAKLMKKAGIQYQKESEIGTVVYVAAGDTFIGSIVIADEIKEDAKRAISALKKAGIKKTVMLTGDAKDTGEAVGEQL
SIDEVHAELLPQHKVDRIETLDKQKLPKEKLLFAGDGINDTPVLARADIGVAMGGLGSDAAVEAADIVIMTDQPSKIAEA
ISIAKRTRTIVWQNIIFALGVKGVFLILGAFGIATMWEAVFSDVGVTLLAVLNAMRVLKVKEM
>Mature_703_residues
MEKVKQEYTLNGLDCSNCAQKIEHEIAGMKGIEACSVNFATSTLTVQVDQNSGEDISLIIKKKVTEIEPHVNATLKEGTK
QAPPESDGRFKKTVARLAAGTVLGAAGFLLPGGTAAEWLLFFLAYLIIGGDVVLRAVKNIFRGRVFDEHFLMTIATLGAF
IIQQYPEGVAVMLFYQIGELFQGAAVTRSRKSISDLMDIRPDYANLQTEGGTVKVSPDEVKAGDIIIVKPGEKVPLDGKV
RAGKSLVDTSALTGESVPREAAPGTEVLSGFVNKNGVLEVEVDKEYSESTVSKILDLVQNASSRKAKTENFITKFAKYYT
PFVVIIALLLAFVPPLIISGALLSDWVYRALVFLVISCPCALVVSIPLGFFGGIGAASKAGILVKGGNYLEALNDVKYAV
FDKTGTLTKGEFAVVKLSPASHVKEDELLEYAALAEHFSGHPIAESIREAYGKEVQADRIKDYSETAGFGVRAVVDGAVI
LAGNAKLMKKAGIQYQKESEIGTVVYVAAGDTFIGSIVIADEIKEDAKRAISALKKAGIKKTVMLTGDAKDTGEAVGEQL
SIDEVHAELLPQHKVDRIETLDKQKLPKEKLLFAGDGINDTPVLARADIGVAMGGLGSDAAVEAADIVIMTDQPSKIAEA
ISIAKRTRTIVWQNIIFALGVKGVFLILGAFGIATMWEAVFSDVGVTLLAVLNAMRVLKVKEM

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=794, Percent_Identity=26.5743073047859, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI115529486, Length=602, Percent_Identity=28.0730897009967, Blast_Score=232, Evalue=9e-61,
Organism=Homo sapiens, GI55743073, Length=547, Percent_Identity=28.5191956124314, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI118498343, Length=239, Percent_Identity=28.0334728033473, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI48762685, Length=157, Percent_Identity=31.2101910828025, Blast_Score=66, Evalue=9e-11,
Organism=Homo sapiens, GI48762689, Length=157, Percent_Identity=31.2101910828025, Blast_Score=66, Evalue=9e-11,
Organism=Homo sapiens, GI48762687, Length=188, Percent_Identity=30.3191489361702, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1789879, Length=706, Percent_Identity=34.5609065155807, Blast_Score=355, Evalue=5e-99,
Organism=Escherichia coli, GI1786691, Length=746, Percent_Identity=28.9544235924933, Blast_Score=252, Evalue=6e-68,
Organism=Escherichia coli, GI1786914, Length=474, Percent_Identity=29.535864978903, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI2367363, Length=158, Percent_Identity=36.7088607594937, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17556548, Length=578, Percent_Identity=30.2768166089965, Blast_Score=208, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI71997269, Length=635, Percent_Identity=22.0472440944882, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71997262, Length=628, Percent_Identity=22.1337579617834, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71997275, Length=628, Percent_Identity=22.1337579617834, Blast_Score=94, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193203356, Length=225, Percent_Identity=26.2222222222222, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203354, Length=229, Percent_Identity=26.6375545851528, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559224, Length=383, Percent_Identity=24.2819843342037, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71995298, Length=270, Percent_Identity=26.2962962962963, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71995291, Length=270, Percent_Identity=26.2962962962963, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71995286, Length=270, Percent_Identity=26.2962962962963, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=558, Percent_Identity=29.0322580645161, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=600, Percent_Identity=26.1666666666667, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321271, Length=216, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221329854, Length=309, Percent_Identity=31.0679611650485, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281366676, Length=355, Percent_Identity=23.943661971831, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24668704, Length=157, Percent_Identity=30.5732484076433, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668708, Length=157, Percent_Identity=30.5732484076433, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366617, Length=157, Percent_Identity=30.5732484076433, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24668696, Length=157, Percent_Identity=30.5732484076433, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161085803, Length=157, Percent_Identity=30.5732484076433, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 75246; Mature: 75246

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVKQEYTLNGLDCSNCAQKIEHEIAGMKGIEACSVNFATSTLTVQVDQNSGEDISLII
CCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEECCCCCCEEEEE
KKKVTEIEPHVNATLKEGTKQAPPESDGRFKKTVARLAAGTVLGAAGFLLPGGTAAEWLL
EHHHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHH
FFLAYLIIGGDVVLRAVKNIFRGRVFDEHFLMTIATLGAFIIQQYPEGVAVMLFYQIGEL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FQGAAVTRSRKSISDLMDIRPDYANLQTEGGTVKVSPDEVKAGDIIIVKPGEKVPLDGKV
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCC
RAGKSLVDTSALTGESVPREAAPGTEVLSGFVNKNGVLEVEVDKEYSESTVSKILDLVQN
CCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHC
ASSRKAKTENFITKFAKYYTPFVVIIALLLAFVPPLIISGALLSDWVYRALVFLVISCPC
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVVSIPLGFFGGIGAASKAGILVKGGNYLEALNDVKYAVFDKTGTLTKGEFAVVKLSPA
HHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHCCEEEECCCCCCCCCCEEEEEECCH
SHVKEDELLEYAALAEHFSGHPIAESIREAYGKEVQADRIKDYSETAGFGVRAVVDGAVI
HHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCEEE
LAGNAKLMKKAGIQYQKESEIGTVVYVAAGDTFIGSIVIADEIKEDAKRAISALKKAGIK
EECCHHHHHHCCCCEECCCCCCEEEEEEECCCCHHHEEEHHHHHHHHHHHHHHHHHCCCC
KTVMLTGDAKDTGEAVGEQLSIDEVHAELLPQHKVDRIETLDKQKLPKEKLLFAGDGIND
EEEEEECCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHEEEECCCCCC
TPVLARADIGVAMGGLGSDAAVEAADIVIMTDQPSKIAEAISIAKRTRTIVWQNIIFALG
CCEEEECCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VKGVFLILGAFGIATMWEAVFSDVGVTLLAVLNAMRVLKVKEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKVKQEYTLNGLDCSNCAQKIEHEIAGMKGIEACSVNFATSTLTVQVDQNSGEDISLII
CCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEECCCCCCEEEEE
KKKVTEIEPHVNATLKEGTKQAPPESDGRFKKTVARLAAGTVLGAAGFLLPGGTAAEWLL
EHHHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHH
FFLAYLIIGGDVVLRAVKNIFRGRVFDEHFLMTIATLGAFIIQQYPEGVAVMLFYQIGEL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FQGAAVTRSRKSISDLMDIRPDYANLQTEGGTVKVSPDEVKAGDIIIVKPGEKVPLDGKV
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCC
RAGKSLVDTSALTGESVPREAAPGTEVLSGFVNKNGVLEVEVDKEYSESTVSKILDLVQN
CCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHC
ASSRKAKTENFITKFAKYYTPFVVIIALLLAFVPPLIISGALLSDWVYRALVFLVISCPC
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVVSIPLGFFGGIGAASKAGILVKGGNYLEALNDVKYAVFDKTGTLTKGEFAVVKLSPA
HHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHCCEEEECCCCCCCCCCEEEEEECCH
SHVKEDELLEYAALAEHFSGHPIAESIREAYGKEVQADRIKDYSETAGFGVRAVVDGAVI
HHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCEEE
LAGNAKLMKKAGIQYQKESEIGTVVYVAAGDTFIGSIVIADEIKEDAKRAISALKKAGIK
EECCHHHHHHCCCCEECCCCCCEEEEEEECCCCHHHEEEHHHHHHHHHHHHHHHHHCCCC
KTVMLTGDAKDTGEAVGEQLSIDEVHAELLPQHKVDRIETLDKQKLPKEKLLFAGDGIND
EEEEEECCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHEEEECCCCCC
TPVLARADIGVAMGGLGSDAAVEAADIVIMTDQPSKIAEAISIAKRTRTIVWQNIIFALG
CCEEEECCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VKGVFLILGAFGIATMWEAVFSDVGVTLLAVLNAMRVLKVKEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]