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The map label for this gene is murC

Identifier: 52786856

GI number: 52786856

Start: 3011828

End: 3013126

Strand: Reverse

Name: murC

Synonym: BLi03131

Alternate gene names: 52786856

Gene position: 3013126-3011828 (Counterclockwise)

Preceding gene: 52786857

Following gene: 52786855

Centisome position: 71.36

GC content: 43.73

Gene sequence:

>1299_bases
ATGACTGTTTATCATTTTGTCGGAATAAAAGGGACAGGTATGAGTCCGCTTGCCCAAATTCTCCATGATAATGGATATAA
TGTCCAAGGATCGGATATCGAAAAGTACATTTTTACACAAACCGCTTTAGAGGAGAGAAATATCCCGATTTATCCGTTTG
ATCCGGAAAATATCAAGCCGGGAATGACTGTTATTGCCGGAAATGCTTTTCCCGACACTCATCCCGAAATTGAAAAAGCG
CAAGCTGAAGGCCTGCCAGTCGTGCGGTATCATAAATTTCTCGGCGATTATCTGAAGAAGTTTACGAGCATTGCCGTAAC
AGGGGCACACGGCAAAACGTCAACGACGGGCCTTTTGTCACATGTCATCAAAAAAGCAAAACCGACTTCTTATCTGATTG
GAGACGGAACTGGAAAAGGCTGCGAAAACAGCGAGTACTTTGTGCTTGAAGCCTGTGAATACAGAAGGCATTTTCTGAGC
TATCAGCCCGATTATGCAATCATGACAAATATTGATTTTGATCATCCCGATTATTTCGCGAATATCGATGATGTATTTGA
TGCATTTCAGACGATGGCATTACAGGTGAACAAGGGAATTATCGCATGCGGTGACGACGAGTATTTGATGAAAATCCATG
CGAACGTTCCAGTCGTATACTACGGCTTTGCCGAGGAAAACGATTTTCAGGCGAGAAATGTCATCAAAAATACTGAGGGC
ACAACGTTCGATGTTTTCGTCAGGAACACATTCTACGACACTTTCTATATACCGGCATACGGCAGCCATAACGTTCTGAA
CGCTTTGGCCGTCATCGCCCTCTGCCATTATGAACAGGTCGATGTCGACATCATTAAAGAAGGATTGCAAACCTTTGGCG
GCGTTAAACGCAGATTTAACGAAAAACATGCCGGCAGCCAAGTGCTGATTGACGATTATGCCCACCATCCGACTGAAATC
ACGGTGACGATTGAAGCAGCCAGACAGAAGTATCCGGAACGGGACATTGTTGCAGTATTTCAACCGCATACATTTACGCG
CACGCAGTCATTCCTGAATGAGTTTGCCGAAAGCCTCAAGAAAGCCGATTATGTATATCTTTGCGATATATTCGGATCTG
CCCGGGAAAACGCAGGAAAGCTGACGATCGGTGATTTGCAGGAGAAAATTCCGCAGGCGAAGCTGATCGATGAAAATGAC
ACATCAATTTTAAAGGAGCATGAAAATGCGGTGTTAATTTTCATGGGCGCAGGTGACATTCAAAAGTATTTAAGAGCATA
TGAAAATGTATTAGCATAA

Upstream 100 bases:

>100_bases
TTATGACTTTGAAGAAAACGATGCGGCCGGGCTTTAGGTTGCAAATTGAAATAAGCGTCATATACTGGGAAGCAGATAGA
CGTTTGTTGGAGGTACTATT

Downstream 100 bases:

>100_bases
CAAGAAAAAGGCAGTGTGAGTCAATCCGCTGCTTTTTTGTACATATGAAGCGGGAGTTTCTGTTAAAGGAATTCACCCGT
GCGTATAGAAAAAGTAAATA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTVYHFVGIKGTGMSPLAQILHDNGYNVQGSDIEKYIFTQTALEERNIPIYPFDPENIKPGMTVIAGNAFPDTHPEIEKA
QAEGLPVVRYHKFLGDYLKKFTSIAVTGAHGKTSTTGLLSHVIKKAKPTSYLIGDGTGKGCENSEYFVLEACEYRRHFLS
YQPDYAIMTNIDFDHPDYFANIDDVFDAFQTMALQVNKGIIACGDDEYLMKIHANVPVVYYGFAEENDFQARNVIKNTEG
TTFDVFVRNTFYDTFYIPAYGSHNVLNALAVIALCHYEQVDVDIIKEGLQTFGGVKRRFNEKHAGSQVLIDDYAHHPTEI
TVTIEAARQKYPERDIVAVFQPHTFTRTQSFLNEFAESLKKADYVYLCDIFGSARENAGKLTIGDLQEKIPQAKLIDEND
TSILKEHENAVLIFMGAGDIQKYLRAYENVLA

Sequences:

>Translated_432_residues
MTVYHFVGIKGTGMSPLAQILHDNGYNVQGSDIEKYIFTQTALEERNIPIYPFDPENIKPGMTVIAGNAFPDTHPEIEKA
QAEGLPVVRYHKFLGDYLKKFTSIAVTGAHGKTSTTGLLSHVIKKAKPTSYLIGDGTGKGCENSEYFVLEACEYRRHFLS
YQPDYAIMTNIDFDHPDYFANIDDVFDAFQTMALQVNKGIIACGDDEYLMKIHANVPVVYYGFAEENDFQARNVIKNTEG
TTFDVFVRNTFYDTFYIPAYGSHNVLNALAVIALCHYEQVDVDIIKEGLQTFGGVKRRFNEKHAGSQVLIDDYAHHPTEI
TVTIEAARQKYPERDIVAVFQPHTFTRTQSFLNEFAESLKKADYVYLCDIFGSARENAGKLTIGDLQEKIPQAKLIDEND
TSILKEHENAVLIFMGAGDIQKYLRAYENVLA
>Mature_431_residues
TVYHFVGIKGTGMSPLAQILHDNGYNVQGSDIEKYIFTQTALEERNIPIYPFDPENIKPGMTVIAGNAFPDTHPEIEKAQ
AEGLPVVRYHKFLGDYLKKFTSIAVTGAHGKTSTTGLLSHVIKKAKPTSYLIGDGTGKGCENSEYFVLEACEYRRHFLSY
QPDYAIMTNIDFDHPDYFANIDDVFDAFQTMALQVNKGIIACGDDEYLMKIHANVPVVYYGFAEENDFQARNVIKNTEGT
TFDVFVRNTFYDTFYIPAYGSHNVLNALAVIALCHYEQVDVDIIKEGLQTFGGVKRRFNEKHAGSQVLIDDYAHHPTEIT
VTIEAARQKYPERDIVAVFQPHTFTRTQSFLNEFAESLKKADYVYLCDIFGSARENAGKLTIGDLQEKIPQAKLIDENDT
SILKEHENAVLIFMGAGDIQKYLRAYENVLA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=29.0672451193059, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790680, Length=386, Percent_Identity=28.7564766839378, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_BACLD (Q65G22)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_080271.2
- RefSeq:   YP_092685.1
- ProteinModelPortal:   Q65G22
- SMR:   Q65G22
- STRING:   Q65G22
- EnsemblBacteria:   EBBACT00000055808
- EnsemblBacteria:   EBBACT00000062148
- GeneID:   3028444
- GeneID:   3098842
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03131
- KEGG:   bli:BL00050
- NMPDR:   fig|279010.5.peg.103
- eggNOG:   COG0773
- GeneTree:   EBGT00050000000630
- HOGENOM:   HBG476594
- ProtClustDB:   PRK00421
- BioCyc:   BLIC279010-1:BLI03131-MONOMER
- BioCyc:   BLIC279010:BL00050-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 48649; Mature: 48518

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYHFVGIKGTGMSPLAQILHDNGYNVQGSDIEKYIFTQTALEERNIPIYPFDPENIKP
CEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCC
GMTVIAGNAFPDTHPEIEKAQAEGLPVVRYHKFLGDYLKKFTSIAVTGAHGKTSTTGLLS
CCEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
HVIKKAKPTSYLIGDGTGKGCENSEYFVLEACEYRRHFLSYQPDYAIMTNIDFDHPDYFA
HHHHHCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHC
NIDDVFDAFQTMALQVNKGIIACGDDEYLMKIHANVPVVYYGFAEENDFQARNVIKNTEG
CHHHHHHHHHHHHEEECCCEEEECCCCEEEEEECCCCEEEEECCCCCCCHHHHHHCCCCC
TTFDVFVRNTFYDTFYIPAYGSHNVLNALAVIALCHYEQVDVDIIKEGLQTFGGVKRRFN
CEEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EKHAGSQVLIDDYAHHPTEITVTIEAARQKYPERDIVAVFQPHTFTRTQSFLNEFAESLK
HHCCCCEEEEECCCCCCCEEEEEEEEHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
KADYVYLCDIFGSARENAGKLTIGDLQEKIPQAKLIDENDTSILKEHENAVLIFMGAGDI
HCCEEEEEECCCCCCCCCCCEEEHHHHHHCCCCEEECCCCHHHHHCCCCEEEEEECCHHH
QKYLRAYENVLA
HHHHHHHHHHCC
>Mature Secondary Structure 
TVYHFVGIKGTGMSPLAQILHDNGYNVQGSDIEKYIFTQTALEERNIPIYPFDPENIKP
EEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCC
GMTVIAGNAFPDTHPEIEKAQAEGLPVVRYHKFLGDYLKKFTSIAVTGAHGKTSTTGLLS
CCEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
HVIKKAKPTSYLIGDGTGKGCENSEYFVLEACEYRRHFLSYQPDYAIMTNIDFDHPDYFA
HHHHHCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHC
NIDDVFDAFQTMALQVNKGIIACGDDEYLMKIHANVPVVYYGFAEENDFQARNVIKNTEG
CHHHHHHHHHHHHEEECCCEEEECCCCEEEEEECCCCEEEEECCCCCCCHHHHHHCCCCC
TTFDVFVRNTFYDTFYIPAYGSHNVLNALAVIALCHYEQVDVDIIKEGLQTFGGVKRRFN
CEEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EKHAGSQVLIDDYAHHPTEITVTIEAARQKYPERDIVAVFQPHTFTRTQSFLNEFAESLK
HHCCCCEEEEECCCCCCCEEEEEEEEHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
KADYVYLCDIFGSARENAGKLTIGDLQEKIPQAKLIDENDTSILKEHENAVLIFMGAGDI
HCCEEEEEECCCCCCCCCCCEEEHHHHHHCCCCEEECCCCHHHHHCCCCEEEEEECCHHH
QKYLRAYENVLA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA